FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909863477> ?p ?o ?g. }

• W2909863477 endingPage "154" @default.
• W2909863477 startingPage "147" @default.
• W2909863477 abstract "Doxorubicin (DOX) area‐under‐the‐curve (AUC) was calculated for 40 dogs with spontaneously occurring cancers using a previously validated limited‐sampling approach. All dogs were administered a dose of 30 mg/m 2 by intravenous infusion and serum samples were collected at 5, 45 and 60 minutes post‐infusion. DOX and its major metabolite, doxorubicinol (doxol), were quantified in serum samples using high‐performance liquid chromatography tandem‐mass spectrometry. Wide interpatient variability was observed in the predicted DOX AUC with a coefficient of variation of 34%. A significant relationship was found between DOX AUC and absolute white blood cell count ( P = 0.003), absolute neutrophil count (ANC; P = 0.002) and surviving fraction of neutrophils ( P = 0.03) approximately 1 week after dosing (nadir). No changes in other hematologic parameters (red blood cells, platelets, lymphocytes, haemoglobin) were found to correlate with DOX AUC. The absolute dose (mg) and the dose per unit body weight (mg/kg) were not significantly correlated with nadir ANC. No relationships were found between maximum serum doxol concentration and myelosuppression. Baseline ANC was also significantly correlated to nadir ANC and a model was constructed using baseline ANC and DOX AUC that significantly described the nadir ANC. These findings demonstrate the important relationship between systemic DOX exposure and degree of neutropenia in dogs, and suggest a potential for individualized, pharmacokinetically‐guided DOX dosing in dogs." @default.
• W2909863477 created "2019-01-25" @default.
• W2909863477 creator A5028214935 @default.
• W2909863477 creator A5032777429 @default.
• W2909863477 creator A5062651848 @default.
• W2909863477 creator A5072152051 @default.
• W2909863477 date "2019-02-04" @default.
• W2909863477 modified "2023-10-13" @default.
• W2909863477 title "Doxorubicin area under the curve is an important predictor of neutropenia in dogs with naturally occurring cancers" @default.
• W2909863477 cites W122262006 @default.
• W2909863477 cites W1609440971 @default.
• W2909863477 cites W1788320651 @default.
• W2909863477 cites W1900066106 @default.
• W2909863477 cites W1901603638 @default.
• W2909863477 cites W2000145541 @default.
• W2909863477 cites W2011336630 @default.
• W2909863477 cites W2012456279 @default.
• W2909863477 cites W2028963840 @default.
• W2909863477 cites W2031527514 @default.
• W2909863477 cites W2033397182 @default.
• W2909863477 cites W2043072347 @default.
• W2909863477 cites W2045243966 @default.
• W2909863477 cites W2045485835 @default.
• W2909863477 cites W2046680655 @default.
• W2909863477 cites W2073111359 @default.
• W2909863477 cites W2104354032 @default.
• W2909863477 cites W2120179724 @default.
• W2909863477 cites W2128140517 @default.
• W2909863477 cites W2132122697 @default.
• W2909863477 cites W2137635736 @default.
• W2909863477 cites W2142287269 @default.
• W2909863477 cites W4240905387 @default.
• W2909863477 cites W4247179436 @default.
• W2909863477 doi "https://doi.org/10.1111/vco.12455" @default.
• W2909863477 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6478528" @default.
• W2909863477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30638304" @default.
• W2909863477 hasPublicationYear "2019" @default.
• W2909863477 type Work @default.
• W2909863477 sameAs 2909863477 @default.
• W2909863477 citedByCount "10" @default.
• W2909863477 countsByYear W29098634772019 @default.
• W2909863477 countsByYear W29098634772020 @default.
• W2909863477 countsByYear W29098634772021 @default.
• W2909863477 countsByYear W29098634772022 @default.
• W2909863477 countsByYear W29098634772023 @default.
• W2909863477 crossrefType "journal-article" @default.
• W2909863477 hasAuthorship W2909863477A5028214935 @default.
• W2909863477 hasAuthorship W2909863477A5032777429 @default.
• W2909863477 hasAuthorship W2909863477A5062651848 @default.
• W2909863477 hasAuthorship W2909863477A5072152051 @default.
• W2909863477 hasBestOaLocation W29098634772 @default.
• W2909863477 hasConcept C112705442 @default.
• W2909863477 hasConcept C126322002 @default.
• W2909863477 hasConcept C126894567 @default.
• W2909863477 hasConcept C127413603 @default.
• W2909863477 hasConcept C146978453 @default.
• W2909863477 hasConcept C185592680 @default.
• W2909863477 hasConcept C19269812 @default.
• W2909863477 hasConcept C2776694085 @default.
• W2909863477 hasConcept C2777063308 @default.
• W2909863477 hasConcept C2777288759 @default.
• W2909863477 hasConcept C2777477808 @default.
• W2909863477 hasConcept C2777501473 @default.
• W2909863477 hasConcept C2781303535 @default.
• W2909863477 hasConcept C2988731192 @default.
• W2909863477 hasConcept C43617362 @default.
• W2909863477 hasConcept C71924100 @default.
• W2909863477 hasConcept C74133956 @default.
• W2909863477 hasConcept C76318530 @default.
• W2909863477 hasConcept C88575799 @default.
• W2909863477 hasConcept C89838059 @default.
• W2909863477 hasConcept C90924648 @default.
• W2909863477 hasConcept C98274493 @default.
• W2909863477 hasConceptScore W2909863477C112705442 @default.
• W2909863477 hasConceptScore W2909863477C126322002 @default.
• W2909863477 hasConceptScore W2909863477C126894567 @default.
• W2909863477 hasConceptScore W2909863477C127413603 @default.
• W2909863477 hasConceptScore W2909863477C146978453 @default.
• W2909863477 hasConceptScore W2909863477C185592680 @default.
• W2909863477 hasConceptScore W2909863477C19269812 @default.
• W2909863477 hasConceptScore W2909863477C2776694085 @default.
• W2909863477 hasConceptScore W2909863477C2777063308 @default.
• W2909863477 hasConceptScore W2909863477C2777288759 @default.
• W2909863477 hasConceptScore W2909863477C2777477808 @default.
• W2909863477 hasConceptScore W2909863477C2777501473 @default.
• W2909863477 hasConceptScore W2909863477C2781303535 @default.
• W2909863477 hasConceptScore W2909863477C2988731192 @default.
• W2909863477 hasConceptScore W2909863477C43617362 @default.
• W2909863477 hasConceptScore W2909863477C71924100 @default.
• W2909863477 hasConceptScore W2909863477C74133956 @default.
• W2909863477 hasConceptScore W2909863477C76318530 @default.
• W2909863477 hasConceptScore W2909863477C88575799 @default.
• W2909863477 hasConceptScore W2909863477C89838059 @default.
• W2909863477 hasConceptScore W2909863477C90924648 @default.
• W2909863477 hasConceptScore W2909863477C98274493 @default.
• W2909863477 hasFunder F4320337351 @default.
• W2909863477 hasIssue "2" @default.
• W2909863477 hasLocation W29098634771 @default.

• next