FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2909903726> ?p ?o ?g. }

• W2909903726 endingPage "10696" @default.
• W2909903726 startingPage "10688" @default.
• W2909903726 abstract "The contribution of proximal tubules (PT) to albumin uptake is now well recognized, however, its regulation is understudied area. There are reports suggesting that insulin resistance is associated with the development of albuminuria in nondiabetic individuals. We have previously reported reduced insulin receptor (IR) expression in renal-tubular-epithelial cells, including PT in various models of insulin resistance. However, the effect of a physiological fall in insulin levels and the role for IR in PT in tubular albumin uptake is not clear. To address these gaps in our understanding, we estimated urine excretion and renal uptake of albumin in fasted and fed C57Bl/6 mice injected with fluorescein isothiocyanate (FITC)-albumin (5 µg/mL/kg body weight, intraperitoneal, n = 6 per group). In addition, we compared spot urine analysis from 33 clinically healthy humans after overnight fasting (when insulin levels are lower than in the fed state) and then at 2 hours after 75 g oral glucose challenge (postprandial). Fasted mice had attenuated renal uptake of FITC-albumin and higher excretion in urine, relative to fed mice ( P = 0.04). Moreover, a significant drop in urine albumin-to-creatinine ratio (ACR) and urine albumin concentration (UAC) was observed in the postprandial state in these subjects ( P = 0.001 and P = 0.017, for ACR and UAC, respectively). The drop was negatively associated with postprandial blood glucose levels (ρ = -0.36, P = 0.03 for ΔUAC and ρ = -0.34, P = 0.05 for ΔACR). To test the role of IR in PT, we analyzed 24-hour urine albumin excretion in male mice with targeted deletion of IR from PT (insulin receptor knockout [IRKO]) and their wild-type (WT) littermates ( n = 7 per group). IRKO mice had significantly higher 24-hour urine albumin excretion relative to WT. Moreover, kidneys from KO mice revealed reduced expression of megalin and cubulin proteins in the PT relative to the WT. We also demonstrated insulin (100 nM) induced albumin internalization in human proximal tubule cells (hPT) and this effect of insulin was attenuated in hydroxy-2-naphthalenylmethylphosphonic acid (100 µM), a tyrosine kinase inhibitor, pretreated hPT. Our findings revealed albumin excretion was attenuated by glucose administration to fasting individuals implying a regulatory role for insulin in PT albumin reabsorption. Thus albuminuria associated with insulin resistance/diabetes may relate not only to glomerular dysfunction but also to impairment in insulin-mediated reabsorption." @default.
• W2909903726 created "2019-01-25" @default.
• W2909903726 creator A5005267637 @default.
• W2909903726 creator A5016797401 @default.
• W2909903726 creator A5040228164 @default.
• W2909903726 creator A5046137263 @default.
• W2909903726 creator A5052724921 @default.
• W2909903726 creator A5072368389 @default.
• W2909903726 date "2019-01-15" @default.
• W2909903726 modified "2023-10-14" @default.
• W2909903726 title "Deletion of insulin receptor in the proximal tubule and fasting augment albumin excretion" @default.
• W2909903726 cites W184677336 @default.
• W2909903726 cites W1965984750 @default.
• W2909903726 cites W1971422032 @default.
• W2909903726 cites W1976656734 @default.
• W2909903726 cites W2008785284 @default.
• W2909903726 cites W2013826519 @default.
• W2909903726 cites W2024425084 @default.
• W2909903726 cites W2026376858 @default.
• W2909903726 cites W2057133669 @default.
• W2909903726 cites W2066775588 @default.
• W2909903726 cites W2078649992 @default.
• W2909903726 cites W2080513099 @default.
• W2909903726 cites W2080695057 @default.
• W2909903726 cites W2085501859 @default.
• W2909903726 cites W2092975641 @default.
• W2909903726 cites W2098527497 @default.
• W2909903726 cites W2099739381 @default.
• W2909903726 cites W2101229247 @default.
• W2909903726 cites W2106124956 @default.
• W2909903726 cites W2107031719 @default.
• W2909903726 cites W2108525019 @default.
• W2909903726 cites W2121280956 @default.
• W2909903726 cites W2138131231 @default.
• W2909903726 cites W2143411942 @default.
• W2909903726 cites W2154104320 @default.
• W2909903726 cites W2154748737 @default.
• W2909903726 cites W2161824703 @default.
• W2909903726 cites W2172759855 @default.
• W2909903726 cites W2272561987 @default.
• W2909903726 cites W2330359364 @default.
• W2909903726 cites W2464596983 @default.
• W2909903726 cites W2754503059 @default.
• W2909903726 doi "https://doi.org/10.1002/jcb.28359" @default.
• W2909903726 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30644120" @default.
• W2909903726 hasPublicationYear "2019" @default.
• W2909903726 type Work @default.
• W2909903726 sameAs 2909903726 @default.
• W2909903726 citedByCount "12" @default.
• W2909903726 countsByYear W29099037262020 @default.
• W2909903726 countsByYear W29099037262021 @default.
• W2909903726 countsByYear W29099037262022 @default.
• W2909903726 countsByYear W29099037262023 @default.
• W2909903726 crossrefType "journal-article" @default.
• W2909903726 hasAuthorship W2909903726A5005267637 @default.
• W2909903726 hasAuthorship W2909903726A5016797401 @default.
• W2909903726 hasAuthorship W2909903726A5040228164 @default.
• W2909903726 hasAuthorship W2909903726A5046137263 @default.
• W2909903726 hasAuthorship W2909903726A5052724921 @default.
• W2909903726 hasAuthorship W2909903726A5072368389 @default.
• W2909903726 hasConcept C10146269 @default.
• W2909903726 hasConcept C126322002 @default.
• W2909903726 hasConcept C134018914 @default.
• W2909903726 hasConcept C159641895 @default.
• W2909903726 hasConcept C2776125364 @default.
• W2909903726 hasConcept C2776174234 @default.
• W2909903726 hasConcept C2777391703 @default.
• W2909903726 hasConcept C2778199505 @default.
• W2909903726 hasConcept C2779306644 @default.
• W2909903726 hasConcept C2780026642 @default.
• W2909903726 hasConcept C2780091579 @default.
• W2909903726 hasConcept C56906281 @default.
• W2909903726 hasConcept C71924100 @default.
• W2909903726 hasConceptScore W2909903726C10146269 @default.
• W2909903726 hasConceptScore W2909903726C126322002 @default.
• W2909903726 hasConceptScore W2909903726C134018914 @default.
• W2909903726 hasConceptScore W2909903726C159641895 @default.
• W2909903726 hasConceptScore W2909903726C2776125364 @default.
• W2909903726 hasConceptScore W2909903726C2776174234 @default.
• W2909903726 hasConceptScore W2909903726C2777391703 @default.
• W2909903726 hasConceptScore W2909903726C2778199505 @default.
• W2909903726 hasConceptScore W2909903726C2779306644 @default.
• W2909903726 hasConceptScore W2909903726C2780026642 @default.
• W2909903726 hasConceptScore W2909903726C2780091579 @default.
• W2909903726 hasConceptScore W2909903726C56906281 @default.
• W2909903726 hasConceptScore W2909903726C71924100 @default.
• W2909903726 hasFunder F4320320721 @default.
• W2909903726 hasIssue "6" @default.
• W2909903726 hasLocation W29099037261 @default.
• W2909903726 hasLocation W29099037262 @default.
• W2909903726 hasOpenAccess W2909903726 @default.
• W2909903726 hasPrimaryLocation W29099037261 @default.
• W2909903726 hasRelatedWork W138803513 @default.
• W2909903726 hasRelatedWork W1986132654 @default.
• W2909903726 hasRelatedWork W2010140898 @default.
• W2909903726 hasRelatedWork W2080135029 @default.
• W2909903726 hasRelatedWork W2082140668 @default.
• W2909903726 hasRelatedWork W2089449544 @default.

• next