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• W2909918062 abstract "Abstract Inhibitor of growth 4 (ING4), a member of the ING family discovered in 2003, has been shown to act as a tumor suppressor and is frequently down-regulated in various human cancers. Numerous published in vivo and in vitro studies have shown that ING4 is responsible for important cancer hallmarks such as pathologic cell cycle arrest, apoptosis, autophagy, contact inhibition, and hypoxic adaptation, and also affects tumor angiogenesis, invasion, and metastasis. These characteristics are typically associated with regulation through chromatin acetylation by binding histone H3 trimethylated at lysine 4 (H3K4me3) and through transcriptional activity of transcription factor P53 and NF-κB. In addition, emerging evidence has indicated that abnormalities in ING4 expression and function play key roles in non-neoplastic disorders. Here, we provide an overview of ING4-modulated chromosome remodeling and transcriptional function, as well as the functional consequences of different genetic variants. We also present the current understanding concerning the role of ING4 in the development of neoplastic and non-neoplastic diseases. These studies offer inspiration for pursuing novel therapeutics for various cancers." @default.
• W2909918062 created "2019-01-25" @default.
• W2909918062 creator A5053616608 @default.
• W2909918062 creator A5067215614 @default.
• W2909918062 creator A5082561285 @default.
• W2909918062 date "2019-01-01" @default.
• W2909918062 modified "2023-10-17" @default.
• W2909918062 title "The essential role of tumor suppressor gene <i>ING4</i> in various human cancers and non-neoplastic disorders" @default.
• W2909918062 cites W1127688908 @default.
• W2909918062 cites W1151994292 @default.
• W2909918062 cites W1504938069 @default.
• W2909918062 cites W1508262999 @default.
• W2909918062 cites W1607861682 @default.
• W2909918062 cites W1650797637 @default.
• W2909918062 cites W1936449500 @default.
• W2909918062 cites W194612039 @default.
• W2909918062 cites W1952022109 @default.
• W2909918062 cites W1965254413 @default.
• W2909918062 cites W1965538713 @default.
• W2909918062 cites W1968246099 @default.
• W2909918062 cites W1968287202 @default.
• W2909918062 cites W1970080542 @default.
• W2909918062 cites W1971032837 @default.
• W2909918062 cites W1974559428 @default.
• W2909918062 cites W1975780233 @default.
• W2909918062 cites W1975820129 @default.
• W2909918062 cites W1979239647 @default.
• W2909918062 cites W1979757961 @default.
• W2909918062 cites W1984952924 @default.
• W2909918062 cites W1985901004 @default.
• W2909918062 cites W1986138943 @default.
• W2909918062 cites W1986432650 @default.
• W2909918062 cites W1989137508 @default.
• W2909918062 cites W1989504358 @default.
• W2909918062 cites W1991596856 @default.
• W2909918062 cites W1991924671 @default.
• W2909918062 cites W1996796696 @default.
• W2909918062 cites W1997275472 @default.
• W2909918062 cites W1998614375 @default.
• W2909918062 cites W2001106708 @default.
• W2909918062 cites W2001174247 @default.
• W2909918062 cites W2002169296 @default.
• W2909918062 cites W2002988912 @default.
• W2909918062 cites W2004068369 @default.
• W2909918062 cites W2009094918 @default.
• W2909918062 cites W2010335752 @default.
• W2909918062 cites W2010664444 @default.
• W2909918062 cites W2011180717 @default.
• W2909918062 cites W2011721592 @default.
• W2909918062 cites W2014371799 @default.
• W2909918062 cites W2015519364 @default.
• W2909918062 cites W2017194719 @default.
• W2909918062 cites W2017749852 @default.
• W2909918062 cites W2021741218 @default.
• W2909918062 cites W2022912968 @default.
• W2909918062 cites W2027929548 @default.
• W2909918062 cites W2028950970 @default.
• W2909918062 cites W2030382441 @default.
• W2909918062 cites W2031360536 @default.
• W2909918062 cites W2032007643 @default.
• W2909918062 cites W2032972355 @default.
• W2909918062 cites W2032995169 @default.
• W2909918062 cites W2037181582 @default.
• W2909918062 cites W2039058093 @default.
• W2909918062 cites W2039989163 @default.
• W2909918062 cites W2040031153 @default.
• W2909918062 cites W2041390691 @default.
• W2909918062 cites W2043765405 @default.
• W2909918062 cites W2048618925 @default.
• W2909918062 cites W2050589382 @default.
• W2909918062 cites W2051273299 @default.
• W2909918062 cites W2052102069 @default.
• W2909918062 cites W2052976363 @default.
• W2909918062 cites W2053164509 @default.
• W2909918062 cites W2054938702 @default.
• W2909918062 cites W2055687981 @default.
• W2909918062 cites W2057644263 @default.
• W2909918062 cites W2057897922 @default.
• W2909918062 cites W2058061167 @default.
• W2909918062 cites W2060176877 @default.
• W2909918062 cites W2060632473 @default.
• W2909918062 cites W2062348957 @default.
• W2909918062 cites W2064269581 @default.
• W2909918062 cites W2064386285 @default.
• W2909918062 cites W2066274999 @default.
• W2909918062 cites W2068004842 @default.
• W2909918062 cites W2068717865 @default.
• W2909918062 cites W2069713835 @default.
• W2909918062 cites W2073450287 @default.
• W2909918062 cites W2074040292 @default.
• W2909918062 cites W2074887253 @default.
• W2909918062 cites W2076531813 @default.
• W2909918062 cites W2076583198 @default.
• W2909918062 cites W2077995946 @default.
• W2909918062 cites W2081271680 @default.
• W2909918062 cites W2081363415 @default.
• W2909918062 cites W2082103392 @default.
• W2909918062 cites W2082572336 @default.
• W2909918062 cites W2085027690 @default.
• W2909918062 cites W2086440255 @default.

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