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- W2909943803 abstract "Background Japanese post-marketing survey (PMS) data demonstrated that the clinical efficacy of abatacept was similar between the young and elderly rheumatoid arthritis (RA) patients, while they have quite different characteristics including age, disease duration, and concomitant drugs. We hypothesised that the predictive factors for clinical outcomes of abatacept were different between the young and elderly patients. Objectives We studied the predictive factors for good clinical response of abatacept in the young and elderly patients, respectively, in this study. Methods Participants were consecutive 463 RA patients treated with abatacept and observed for longer than 52 weeks in the TBCR, a Japanese multicenter registry system for RA patients treated with biologics. Univariate and multivariate logistic regression analysis was used to study predictive factors for achievement of low disease activity (LDA) at 52 weeks, separately in the young ( Results Mean age was 55.3/74.0 years (young/elderly), disease duration was 10.2/12.8 years, DAS28-CRP was 4.34/4.40 at baseline, concomitant MTX was used in 55.4/37.1%, concomitant steroid was used in 51.0/49.6%, and proportion of bio-naive was 49.3/63.3%. As shown in table 1, multivariate analysis revealed that no history of previous biologics and lower DAS28 score at baseline was the independent positive predictors in both young and elderly group. Interestingly, ACPA positivity was significant predictor only in the young group. The ACPA positive patients showed the significantly higher proportion of LDA achievement at 52 weeks, only in the young group (figure 1). Conclusions It has been reported that lower proportion of the elderly onset RA (EORA) patients has ACPA positivity, and some reports have previously demonstrated that the ACPA negative was negatively associated with good clinical outcomes of abatacept. Our current results suggested that the effect of ACPA positivity on the clinical results of abatacept treatment was different between ages. Abatacept would be a valuable treatment option in the ACPA negative elderly RA patients. Disclosure of Interest None declared" @default.
- W2909943803 created "2019-01-25" @default.
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- W2909943803 date "2018-06-01" @default.
- W2909943803 modified "2023-09-28" @default.
- W2909943803 title "THU0214 Predictive factors for achievement of low disease activity at 52 weeks are different between young and elderly rheumatoid arthritis patients treated with abatacept" @default.
- W2909943803 doi "https://doi.org/10.1136/annrheumdis-2018-eular.3382" @default.
- W2909943803 hasPublicationYear "2018" @default.
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