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• W2909955610 abstract "TAp73 is a tumor suppressor, which compensates for p53 loss and induces apoptosis in tumors in response to genotoxic stress or small-molecule treatments. Pancreatic ductal adenocarcinoma has a late onset of the disease, responds poorly to the existing therapies and has a very low survival rates.Here, using drug-repurposing approach, we found that protoporphyrin IX (PpIX) and benzoporphyrin derivative (BPD) monoacid ring A activate TAp73 and induce apoptosis in pancreatic cancer cells. PpIX and BPD induce reactive oxygen species and inhibit thioredoxin reductase 1.Thus, PpIX and BPD target cancer cells' vulnerabilities namely activate TAp73 tumor suppressor and inhibit oncogenic Trx1. Our findings may contribute to faster repurposing of PpIX and BPD to treat pancreatic tumors." @default.
• W2909955610 created "2019-01-25" @default.
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• W2909955610 date "2019-02-01" @default.
• W2909955610 modified "2023-10-18" @default.
• W2909955610 title "Activation of TAp73 and inhibition of TrxR by Verteporfin for improved cancer therapy in <i>TP53</i> mutant pancreatic tumors" @default.
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• W2909955610 doi "https://doi.org/10.4155/fsoa-2018-0082" @default.
• W2909955610 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6391631" @default.
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