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- W2910008477 abstract "T-type calcium channels serve an essential role in the functioning of the nervous system. They exhibit unique properties among voltage-gated calcium channels, and mediate specific roles in brain function. Over the recent years, it has come to light that a number of chronic neurological disorders arise from defects in T-type channel function. The question then arises as to whether T-type channels could represent a relevant druggable target. In this review, we introduce the diversity, molecular structure, and principal electrophysiological properties of T-type channels. Then, we highlight their role in neuronal development, and their pathophysiological role in the nervous system. Finally, we discuss the potential of T-type channels as therapeutic targets in light of recent advances in their pharmacopoeia." @default.
- W2910008477 created "2019-01-25" @default.
- W2910008477 creator A5011448945 @default.
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- W2910008477 date "2019-03-01" @default.
- W2910008477 modified "2023-10-03" @default.
- W2910008477 title "T-type calcium channels: From molecule to therapeutic opportunities" @default.
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- W2910008477 doi "https://doi.org/10.1016/j.biocel.2019.01.008" @default.
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