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• W2910010391 startingPage "1824" @default.
• W2910010391 abstract "Complexes [Zn(L)2(H2O)] (1), [Mn(L)2(CH3OH)2] (2), and [Fe(L)2(CH3OH)Cl] (3) (H–L = 6-hydroxyloxoisoaporphine) were synthesized and characterized. Complex 1 is a five-coordinate distorted tetragonal pyramid, whereas complexes 2 and 3 are six-coordinate distorted octahedral structures. Complexes 1–3 exhibited selective cytotoxicity against MGC80-3, Hep-G2, BEL-7404, and T-24 cells, with IC50 values in the range of 8.19–15.98 µm, and low cytotoxicity to HL-7702 cells. T-24 was the tumor cell most sensitive to complexes 1–3. Complexes 1–3 induced T-24 cell arrest in the G1 and G2/M phases, which led to the upregulation of p27, CDK2, p53, and p21, and downregulation of Cyclin E, Chk1, CDC25A, and Chk2. Complexes 1–3 triggered apoptosis in T-24 cells by a mitochondrial-dysfunction pathway. The interaction of complexes 1–3 with DNA occurs most likely by means of an intercalation and cleavage mode." @default.
• W2910010391 created "2019-01-25" @default.
• W2910010391 creator A5045123174 @default.
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• W2910010391 creator A5075356499 @default.
• W2910010391 creator A5087537584 @default.
• W2910010391 date "2017-02-21" @default.
• W2910010391 modified "2023-09-25" @default.
• W2910010391 title "Synthesis, Crystal Structure, Cytotoxicity, and Mechanism of Action of Zn ^II , Mn ^II , and Fe ^III Complexes with 6‐Hydroxyloxoisoaporphine" @default.
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• W2910010391 doi "https://doi.org/10.1002/ejic.201601030" @default.
• W2910010391 hasPublicationYear "2017" @default.
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