Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910030957> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2910030957 endingPage "378" @default.
- W2910030957 startingPage "370" @default.
- W2910030957 abstract "Polycystic ovary syndrome (PCOS) is the most common endocrinopathy and an important metabolic disorder in women of reproductive age. Insulin resistance (IR) is one of its most important clinical features in patients with PCOS. Androgen excess-induced mitochondrial dysfunction contributes to skeletal muscle IR in dehydroepiandrosterone (DHEA)-induced PCOS mice. The effect of androgen excess on the skeletal muscle, however, is incompletely characterized. A nontargeted metabolomics approach was thus applied to analyze the metabolites in skeletal muscle of DHEA-induced PCOS mice. Data from metabolomic analysis revealed the significant changes in 32 metabolites and the marked impact of five metabolic pathways. ATP production was also found to be significantly reduced in skeletal muscle of DHEA mice. Combined with the quantification of type I and II myofibers and lipid measurement in the skeletal muscle of the mice, the results from the present study supported the role of mitochondrial impairment rather than lipid accumulation in the pathogenesis of skeletal muscle IR in DHEA-induced PCOS mice. In summary, we show here for the first time the profile of the metabolites in the skeletal muscle of DHEA-induced PCOS mice which exhibit IR. The work would help better understand the pathology of skeletal muscle IR in PCOS." @default.
- W2910030957 created "2019-01-25" @default.
- W2910030957 creator A5001535444 @default.
- W2910030957 creator A5040525431 @default.
- W2910030957 creator A5052059979 @default.
- W2910030957 creator A5054588033 @default.
- W2910030957 creator A5059215418 @default.
- W2910030957 creator A5059387026 @default.
- W2910030957 creator A5079243585 @default.
- W2910030957 date "2019-01-22" @default.
- W2910030957 modified "2023-10-16" @default.
- W2910030957 title "Nontargeted metabolomic analysis of skeletal muscle in a dehydroepiandrosterone‐induced mouse model of polycystic ovary syndrome" @default.
- W2910030957 cites W1988474004 @default.
- W2910030957 cites W2003651092 @default.
- W2910030957 cites W2074961980 @default.
- W2910030957 cites W2097934251 @default.
- W2910030957 cites W2115437409 @default.
- W2910030957 cites W2149226861 @default.
- W2910030957 cites W2156384298 @default.
- W2910030957 cites W2168498537 @default.
- W2910030957 cites W2229146261 @default.
- W2910030957 cites W2607345625 @default.
- W2910030957 cites W2772391645 @default.
- W2910030957 cites W2782727455 @default.
- W2910030957 cites W2793744353 @default.
- W2910030957 cites W2793887346 @default.
- W2910030957 doi "https://doi.org/10.1002/mrd.23111" @default.
- W2910030957 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30633842" @default.
- W2910030957 hasPublicationYear "2019" @default.
- W2910030957 type Work @default.
- W2910030957 sameAs 2910030957 @default.
- W2910030957 citedByCount "8" @default.
- W2910030957 countsByYear W29100309572020 @default.
- W2910030957 countsByYear W29100309572021 @default.
- W2910030957 countsByYear W29100309572022 @default.
- W2910030957 countsByYear W29100309572023 @default.
- W2910030957 crossrefType "journal-article" @default.
- W2910030957 hasAuthorship W2910030957A5001535444 @default.
- W2910030957 hasAuthorship W2910030957A5040525431 @default.
- W2910030957 hasAuthorship W2910030957A5052059979 @default.
- W2910030957 hasAuthorship W2910030957A5054588033 @default.
- W2910030957 hasAuthorship W2910030957A5059215418 @default.
- W2910030957 hasAuthorship W2910030957A5059387026 @default.
- W2910030957 hasAuthorship W2910030957A5079243585 @default.
- W2910030957 hasConcept C126322002 @default.
- W2910030957 hasConcept C134018914 @default.
- W2910030957 hasConcept C21565614 @default.
- W2910030957 hasConcept C2776992908 @default.
- W2910030957 hasConcept C2777391703 @default.
- W2910030957 hasConcept C2777911890 @default.
- W2910030957 hasConcept C2779306644 @default.
- W2910030957 hasConcept C2779959927 @default.
- W2910030957 hasConcept C2910605048 @default.
- W2910030957 hasConcept C3018442814 @default.
- W2910030957 hasConcept C60644358 @default.
- W2910030957 hasConcept C71315377 @default.
- W2910030957 hasConcept C71924100 @default.
- W2910030957 hasConcept C86803240 @default.
- W2910030957 hasConceptScore W2910030957C126322002 @default.
- W2910030957 hasConceptScore W2910030957C134018914 @default.
- W2910030957 hasConceptScore W2910030957C21565614 @default.
- W2910030957 hasConceptScore W2910030957C2776992908 @default.
- W2910030957 hasConceptScore W2910030957C2777391703 @default.
- W2910030957 hasConceptScore W2910030957C2777911890 @default.
- W2910030957 hasConceptScore W2910030957C2779306644 @default.
- W2910030957 hasConceptScore W2910030957C2779959927 @default.
- W2910030957 hasConceptScore W2910030957C2910605048 @default.
- W2910030957 hasConceptScore W2910030957C3018442814 @default.
- W2910030957 hasConceptScore W2910030957C60644358 @default.
- W2910030957 hasConceptScore W2910030957C71315377 @default.
- W2910030957 hasConceptScore W2910030957C71924100 @default.
- W2910030957 hasConceptScore W2910030957C86803240 @default.
- W2910030957 hasFunder F4320321001 @default.
- W2910030957 hasIssue "4" @default.
- W2910030957 hasLocation W29100309571 @default.
- W2910030957 hasLocation W29100309572 @default.
- W2910030957 hasOpenAccess W2910030957 @default.
- W2910030957 hasPrimaryLocation W29100309571 @default.
- W2910030957 hasRelatedWork W2001983775 @default.
- W2910030957 hasRelatedWork W2006714892 @default.
- W2910030957 hasRelatedWork W2037685764 @default.
- W2910030957 hasRelatedWork W2071127270 @default.
- W2910030957 hasRelatedWork W2074423099 @default.
- W2910030957 hasRelatedWork W2108727975 @default.
- W2910030957 hasRelatedWork W2140290057 @default.
- W2910030957 hasRelatedWork W3028840175 @default.
- W2910030957 hasRelatedWork W3201117601 @default.
- W2910030957 hasRelatedWork W4239058953 @default.
- W2910030957 hasVolume "86" @default.
- W2910030957 isParatext "false" @default.
- W2910030957 isRetracted "false" @default.
- W2910030957 magId "2910030957" @default.
- W2910030957 workType "article" @default.