FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910034102> ?p ?o ?g. }

• W2910034102 abstract ".Streptococcus pneumoniae is a highly impactful bacterial pathogen on a global scale. The principal pneumococcal virulence factor and target of effective vaccines is its polysaccharide capsule, of which there are many structurally distinct forms. Here we describe four distinct strains of three Mitis group commensal species (Streptococcus infantis, Streptococcus mitis, and Streptococcus oralis) recovered from upper respiratory tract specimens from adults in Kenya and the United States that were PCR-positive for the pneumococcal serotype 5 specific gene, wzy5. For each of the 4 strains, the 15 genes comprising the capsular polysaccharide biosynthetic gene cluster (cps5) shared the same order found in serotype 5 pneumococci, and each of the five serotype 5-specific genes from the serotype 5 pneumococcal reference strain shared 76 – 99% sequence identity with the non-pneumococcal counterparts. Double-diffusion experiments demonstrated specific reactivity with pneumococcal serotype 5 typing sera. Antiserum raised against S. mitis strain KE67013 specifically reacted with serotype 5 pneumococci for a positive Quellung reaction and stimulated serotype 5 specific opsonophagocytic killing of pneumococci. Four additional commensal strains, identified using PCR serotyping assays on pharyngeal specimens, revealeded cps loci highly homologous to those of pneumococci of serotypes 12F, 15A, 18C, and 33F. These data, in particular the species and strain diversity shown for serotype 5, highlight the existence of a broad non-pneumococcal species reservoir in the upper respiratory tract for the expression of capsular polysaccharides that are structurally related or identical to those expressed by many different pneumococcal serotypes. Very little is known about the genetic and antigenic capsular diversity among the vast array of commensal streptococcal strains that represent multiple diverse species. This discovery of serotype 5 strains within three different commensal species is suggestive that extensive capsular serologic overlap exists between pneumococci and other members of the diverse Mitis group. These findings may have implications for our current understanding of naturally acquired immunity to S. pneumoniae and pneumococcal serotype distributions in different global regions. Further characterization of commensal strains carrying homologs of serotype-specific genes previously thought to be specific for pneumococci of known serotypes may shed light on the evolution of these important loci." @default.
• W2910034102 created "2019-01-25" @default.
• W2910034102 creator A5002177202 @default.
• W2910034102 creator A5009656341 @default.
• W2910034102 creator A5027840017 @default.
• W2910034102 creator A5029173675 @default.
• W2910034102 creator A5030650222 @default.
• W2910034102 creator A5037723243 @default.
• W2910034102 creator A5041183761 @default.
• W2910034102 creator A5047187139 @default.
• W2910034102 creator A5051844287 @default.
• W2910034102 creator A5059297343 @default.
• W2910034102 creator A5060314796 @default.
• W2910034102 creator A5068444424 @default.
• W2910034102 creator A5068674119 @default.
• W2910034102 creator A5069420370 @default.
• W2910034102 creator A5071279105 @default.
• W2910034102 creator A5073330626 @default.
• W2910034102 creator A5074464522 @default.
• W2910034102 creator A5078442226 @default.
• W2910034102 creator A5086780557 @default.
• W2910034102 date "2019-01-08" @default.
• W2910034102 modified "2023-10-17" @default.
• W2910034102 title "Streptococcus infantis, Streptococcus mitis, and Streptococcus oralis Strains With Highly Similar cps5 Loci and Antigenic Relatedness to Serotype 5 Pneumococci" @default.
• W2910034102 cites W1064010436 @default.
• W2910034102 cites W1456171542 @default.
• W2910034102 cites W1954112402 @default.
• W2910034102 cites W1972265710 @default.
• W2910034102 cites W2001026274 @default.
• W2910034102 cites W2017631505 @default.
• W2910034102 cites W2023964275 @default.
• W2910034102 cites W2026275325 @default.
• W2910034102 cites W2042890596 @default.
• W2910034102 cites W2044417671 @default.
• W2910034102 cites W2068383131 @default.
• W2910034102 cites W2069773013 @default.
• W2910034102 cites W2084908329 @default.
• W2910034102 cites W2105008621 @default.
• W2910034102 cites W2109624989 @default.
• W2910034102 cites W2110005071 @default.
• W2910034102 cites W2112821341 @default.
• W2910034102 cites W2117110327 @default.
• W2910034102 cites W2117383615 @default.
• W2910034102 cites W2122035381 @default.
• W2910034102 cites W2122118888 @default.
• W2910034102 cites W2128173146 @default.
• W2910034102 cites W2136856303 @default.
• W2910034102 cites W2142127653 @default.
• W2910034102 cites W2149176649 @default.
• W2910034102 cites W2158109932 @default.
• W2910034102 cites W2167221249 @default.
• W2910034102 cites W2266025288 @default.
• W2910034102 cites W2310011870 @default.
• W2910034102 cites W2512842904 @default.
• W2910034102 cites W2515546166 @default.
• W2910034102 cites W2555942845 @default.
• W2910034102 cites W2749092259 @default.
• W2910034102 cites W2901383111 @default.
• W2910034102 cites W2904424812 @default.
• W2910034102 doi "https://doi.org/10.3389/fmicb.2018.03199" @default.
• W2910034102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6332807" @default.
• W2910034102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30671034" @default.
• W2910034102 hasPublicationYear "2019" @default.
• W2910034102 type Work @default.
• W2910034102 sameAs 2910034102 @default.
• W2910034102 citedByCount "40" @default.
• W2910034102 countsByYear W29100341022019 @default.
• W2910034102 countsByYear W29100341022020 @default.
• W2910034102 countsByYear W29100341022021 @default.
• W2910034102 countsByYear W29100341022022 @default.
• W2910034102 countsByYear W29100341022023 @default.
• W2910034102 crossrefType "journal-article" @default.
• W2910034102 hasAuthorship W2910034102A5002177202 @default.
• W2910034102 hasAuthorship W2910034102A5009656341 @default.
• W2910034102 hasAuthorship W2910034102A5027840017 @default.
• W2910034102 hasAuthorship W2910034102A5029173675 @default.
• W2910034102 hasAuthorship W2910034102A5030650222 @default.
• W2910034102 hasAuthorship W2910034102A5037723243 @default.
• W2910034102 hasAuthorship W2910034102A5041183761 @default.
• W2910034102 hasAuthorship W2910034102A5047187139 @default.
• W2910034102 hasAuthorship W2910034102A5051844287 @default.
• W2910034102 hasAuthorship W2910034102A5059297343 @default.
• W2910034102 hasAuthorship W2910034102A5060314796 @default.
• W2910034102 hasAuthorship W2910034102A5068444424 @default.
• W2910034102 hasAuthorship W2910034102A5068674119 @default.
• W2910034102 hasAuthorship W2910034102A5069420370 @default.
• W2910034102 hasAuthorship W2910034102A5071279105 @default.
• W2910034102 hasAuthorship W2910034102A5073330626 @default.
• W2910034102 hasAuthorship W2910034102A5074464522 @default.
• W2910034102 hasAuthorship W2910034102A5078442226 @default.
• W2910034102 hasAuthorship W2910034102A5086780557 @default.
• W2910034102 hasBestOaLocation W29100341021 @default.
• W2910034102 hasConcept C10389963 @default.
• W2910034102 hasConcept C104317684 @default.
• W2910034102 hasConcept C159047783 @default.
• W2910034102 hasConcept C2777480049 @default.
• W2910034102 hasConcept C2778276568 @default.
• W2910034102 hasConcept C2778663903 @default.
• W2910034102 hasConcept C2781253189 @default.
• W2910034102 hasConcept C2781381541 @default.

• next