Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910040256> ?p ?o ?g. }
- W2910040256 endingPage "1009.e4" @default.
- W2910040256 startingPage "996" @default.
- W2910040256 abstract "Genetic and biochemical defects of mitochondrial function are a major cause of human disease, but their link to mitochondrial morphology in situ has not been defined. Here, we develop a quantitative three-dimensional approach to map mitochondrial network organization in human muscle at electron microscopy resolution. We establish morphological differences between human and mouse and among patients with mitochondrial DNA (mtDNA) diseases compared to healthy controls. We also define the ultrastructure and prevalence of mitochondrial nanotunnels, which exist as either free-ended or connecting membrane protrusions across non-adjacent mitochondria. A multivariate model integrating mitochondrial volume, morphological complexity, and branching anisotropy computed across individual mitochondria and mitochondrial populations identifies increased proportion of simple mitochondria and nanotunnels as a discriminant signature of mitochondrial stress. Overall, these data define the nature of the mitochondrial network in human muscle, quantify human-mouse differences, and suggest potential morphological markers of mitochondrial dysfunction in human tissues." @default.
- W2910040256 created "2019-01-25" @default.
- W2910040256 creator A5007355607 @default.
- W2910040256 creator A5015188516 @default.
- W2910040256 creator A5018057407 @default.
- W2910040256 creator A5019406546 @default.
- W2910040256 creator A5027461916 @default.
- W2910040256 creator A5035268428 @default.
- W2910040256 creator A5039800935 @default.
- W2910040256 creator A5042405605 @default.
- W2910040256 creator A5044816818 @default.
- W2910040256 creator A5045832983 @default.
- W2910040256 creator A5046154325 @default.
- W2910040256 creator A5046288998 @default.
- W2910040256 creator A5054081638 @default.
- W2910040256 creator A5081965846 @default.
- W2910040256 creator A5090359421 @default.
- W2910040256 date "2019-01-01" @default.
- W2910040256 modified "2023-10-17" @default.
- W2910040256 title "Quantitative 3D Mapping of the Human Skeletal Muscle Mitochondrial Network" @default.
- W2910040256 cites W1500436940 @default.
- W2910040256 cites W1521947818 @default.
- W2910040256 cites W1522225217 @default.
- W2910040256 cites W1766184155 @default.
- W2910040256 cites W1940751968 @default.
- W2910040256 cites W1968605364 @default.
- W2910040256 cites W1972621040 @default.
- W2910040256 cites W1976196662 @default.
- W2910040256 cites W1981875905 @default.
- W2910040256 cites W2007546912 @default.
- W2910040256 cites W2013446674 @default.
- W2910040256 cites W2016581978 @default.
- W2910040256 cites W2019455536 @default.
- W2910040256 cites W2026308971 @default.
- W2910040256 cites W2031900290 @default.
- W2910040256 cites W2041114544 @default.
- W2910040256 cites W2042138321 @default.
- W2910040256 cites W2051273846 @default.
- W2910040256 cites W2053432607 @default.
- W2910040256 cites W2054511417 @default.
- W2910040256 cites W2057695252 @default.
- W2910040256 cites W2057741310 @default.
- W2910040256 cites W2058763646 @default.
- W2910040256 cites W2059320820 @default.
- W2910040256 cites W2064080426 @default.
- W2910040256 cites W2065324486 @default.
- W2910040256 cites W2074710857 @default.
- W2910040256 cites W2076941428 @default.
- W2910040256 cites W2078475387 @default.
- W2910040256 cites W2084505879 @default.
- W2910040256 cites W2091199047 @default.
- W2910040256 cites W2097936772 @default.
- W2910040256 cites W2102409753 @default.
- W2910040256 cites W2114063620 @default.
- W2910040256 cites W2116230576 @default.
- W2910040256 cites W2121077787 @default.
- W2910040256 cites W2131221527 @default.
- W2910040256 cites W2131415852 @default.
- W2910040256 cites W2131666074 @default.
- W2910040256 cites W2132673730 @default.
- W2910040256 cites W2133232243 @default.
- W2910040256 cites W2137844183 @default.
- W2910040256 cites W2139302008 @default.
- W2910040256 cites W2143454033 @default.
- W2910040256 cites W2151698573 @default.
- W2910040256 cites W2161336914 @default.
- W2910040256 cites W2165015714 @default.
- W2910040256 cites W2224354397 @default.
- W2910040256 cites W2272813075 @default.
- W2910040256 cites W2441892396 @default.
- W2910040256 cites W2487409056 @default.
- W2910040256 cites W2577928160 @default.
- W2910040256 cites W2606122737 @default.
- W2910040256 cites W2622172874 @default.
- W2910040256 cites W2742984768 @default.
- W2910040256 cites W2766665344 @default.
- W2910040256 cites W2792919287 @default.
- W2910040256 cites W2809177340 @default.
- W2910040256 cites W2883224062 @default.
- W2910040256 cites W2903334028 @default.
- W2910040256 cites W2950243670 @default.
- W2910040256 cites W2950985821 @default.
- W2910040256 cites W4210476933 @default.
- W2910040256 cites W4210774303 @default.
- W2910040256 doi "https://doi.org/10.1016/j.celrep.2019.01.010" @default.
- W2910040256 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6519930" @default.
- W2910040256 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30943412" @default.
- W2910040256 hasPublicationYear "2019" @default.
- W2910040256 type Work @default.
- W2910040256 sameAs 2910040256 @default.
- W2910040256 citedByCount "105" @default.
- W2910040256 countsByYear W29100402562019 @default.
- W2910040256 countsByYear W29100402562020 @default.
- W2910040256 countsByYear W29100402562021 @default.
- W2910040256 countsByYear W29100402562022 @default.
- W2910040256 countsByYear W29100402562023 @default.
- W2910040256 crossrefType "journal-article" @default.
- W2910040256 hasAuthorship W2910040256A5007355607 @default.