Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910040477> ?p ?o ?g. }
- W2910040477 abstract "Abstract CD123 (IL-3Rα) is frequently expressed by malignant Hodgkin lymphoma (HL) cells. Naked monoclonal antibodies (mAb) against HL lack clinical benefit, partially due to absence of natural killer (NK) cells in the tumor microenvironment. Here we show that the combination of a fully humanized anti-CD123 mAb (CSL362) and high-affinity Fcγ-receptor NK-92 cells (haNK) effectively target and kill HL cells in vitro. First, we confirmed high expression of CD123 in 2 of the 3 HL cell lines (KM-H2 and L-428), and its absence in NK cells. Cytotoxicity of haNK cells against CD123-positive HL cells was significantly higher in the presence of CSL362. This was also shown with IL-15-activated primary NK cells, although haNK cells showed a 10.87-fold lower estimated half-maximal stimulatory effective concentration (EC 50 ). CSL362 facilitated a significant increase in the expression of CD107a, intracellular IFN-γ and TNF-α and enhanced expression of c-JUN , PLD-1 , and ARF6 by NK cells. Inhibition of the ARF6–PLD-1 axis (NAV2729), but not of the MAPK pathway (U0126), completely abrogated CSL362-facilitated antibody-dependent cell-mediated cytotoxicity (ADCC) in haNK and activated primary NK cells. Our results support CD123 as an immunotherapeutic target for HL and the combination of NK cells and CSL362 as a treatment strategy for HL." @default.
- W2910040477 created "2019-01-25" @default.
- W2910040477 creator A5008942810 @default.
- W2910040477 creator A5019579192 @default.
- W2910040477 creator A5033483433 @default.
- W2910040477 creator A5039425914 @default.
- W2910040477 creator A5050723566 @default.
- W2910040477 creator A5062767676 @default.
- W2910040477 creator A5068149083 @default.
- W2910040477 creator A5070851772 @default.
- W2910040477 creator A5071417704 @default.
- W2910040477 creator A5084879612 @default.
- W2910040477 date "2019-01-15" @default.
- W2910040477 modified "2023-10-16" @default.
- W2910040477 title "Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1" @default.
- W2910040477 cites W1491394604 @default.
- W2910040477 cites W1603078860 @default.
- W2910040477 cites W1784889530 @default.
- W2910040477 cites W1967742488 @default.
- W2910040477 cites W1968101362 @default.
- W2910040477 cites W2013971016 @default.
- W2910040477 cites W2016190362 @default.
- W2910040477 cites W2017558550 @default.
- W2910040477 cites W2024807467 @default.
- W2910040477 cites W2036088843 @default.
- W2910040477 cites W2039970555 @default.
- W2910040477 cites W2044360617 @default.
- W2910040477 cites W2049004281 @default.
- W2910040477 cites W2050937173 @default.
- W2910040477 cites W2061635000 @default.
- W2910040477 cites W2067814594 @default.
- W2910040477 cites W2070387456 @default.
- W2910040477 cites W2087516193 @default.
- W2910040477 cites W2087762900 @default.
- W2910040477 cites W2093658044 @default.
- W2910040477 cites W2097339599 @default.
- W2910040477 cites W2099570622 @default.
- W2910040477 cites W2103827956 @default.
- W2910040477 cites W2104943495 @default.
- W2910040477 cites W2109502548 @default.
- W2910040477 cites W2113811237 @default.
- W2910040477 cites W2114005457 @default.
- W2910040477 cites W2114908650 @default.
- W2910040477 cites W2119904228 @default.
- W2910040477 cites W2126067141 @default.
- W2910040477 cites W2127022844 @default.
- W2910040477 cites W2196491217 @default.
- W2910040477 cites W2221432805 @default.
- W2910040477 cites W2298503769 @default.
- W2910040477 cites W2335984750 @default.
- W2910040477 cites W2521461373 @default.
- W2910040477 cites W2529198051 @default.
- W2910040477 cites W2556149828 @default.
- W2910040477 cites W2572174216 @default.
- W2910040477 cites W2584614071 @default.
- W2910040477 cites W2603628708 @default.
- W2910040477 cites W2620976364 @default.
- W2910040477 cites W2735011415 @default.
- W2910040477 cites W2753081026 @default.
- W2910040477 cites W2792615105 @default.
- W2910040477 doi "https://doi.org/10.1038/s41408-018-0168-2" @default.
- W2910040477 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6333842" @default.
- W2910040477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30647406" @default.
- W2910040477 hasPublicationYear "2019" @default.
- W2910040477 type Work @default.
- W2910040477 sameAs 2910040477 @default.
- W2910040477 citedByCount "11" @default.
- W2910040477 countsByYear W29100404772019 @default.
- W2910040477 countsByYear W29100404772020 @default.
- W2910040477 countsByYear W29100404772021 @default.
- W2910040477 countsByYear W29100404772023 @default.
- W2910040477 crossrefType "journal-article" @default.
- W2910040477 hasAuthorship W2910040477A5008942810 @default.
- W2910040477 hasAuthorship W2910040477A5019579192 @default.
- W2910040477 hasAuthorship W2910040477A5033483433 @default.
- W2910040477 hasAuthorship W2910040477A5039425914 @default.
- W2910040477 hasAuthorship W2910040477A5050723566 @default.
- W2910040477 hasAuthorship W2910040477A5062767676 @default.
- W2910040477 hasAuthorship W2910040477A5068149083 @default.
- W2910040477 hasAuthorship W2910040477A5070851772 @default.
- W2910040477 hasAuthorship W2910040477A5071417704 @default.
- W2910040477 hasAuthorship W2910040477A5084879612 @default.
- W2910040477 hasBestOaLocation W29100404771 @default.
- W2910040477 hasConcept C109316439 @default.
- W2910040477 hasConcept C153911025 @default.
- W2910040477 hasConcept C159654299 @default.
- W2910040477 hasConcept C185592680 @default.
- W2910040477 hasConcept C202751555 @default.
- W2910040477 hasConcept C203014093 @default.
- W2910040477 hasConcept C40677261 @default.
- W2910040477 hasConcept C502942594 @default.
- W2910040477 hasConcept C542903549 @default.
- W2910040477 hasConcept C54355233 @default.
- W2910040477 hasConcept C55493867 @default.
- W2910040477 hasConcept C81885089 @default.
- W2910040477 hasConcept C86803240 @default.
- W2910040477 hasConceptScore W2910040477C109316439 @default.
- W2910040477 hasConceptScore W2910040477C153911025 @default.
- W2910040477 hasConceptScore W2910040477C159654299 @default.
- W2910040477 hasConceptScore W2910040477C185592680 @default.