Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910040707> ?p ?o ?g. }
- W2910040707 endingPage "5" @default.
- W2910040707 startingPage "1" @default.
- W2910040707 abstract "Nifedipine, a known substrate to breast cancer resistance protein (ABCG2/BCRP), is used for the treatment of hypertension during breastfeeding. This study aimed to evaluate the effect of ABCG2 c.421C>A on nifedipine transfer to breast milk (BM) in hypertensive women. Nineteen hypertensive breastfeeding women treated with 20 mg nifedipine every 12 hours were investigated. Blood and BM samples were collected simultaneously 15-30 days after delivery and at least 15 days after drug treatment. Patients genotyped as ABCG2 c.421CC showed nifedipine plasma and BM concentrations ranging from 8.32-178.1 ng/mL and 4.8-58.5 ng/mL, respectively. ABCG2 c.421C>A showed a trend towards significance (p = 0.0793) on nifedipine in BM, with concentrations approximately 3 times higher in the heterozygous 421 CA (29 ng/mL) in comparison to 421 CC (10.5 ng/mL). Nifedipine BM/plasma ratio was significantly lower in 421CC when compared to 421CA (p = 0.01). In conclusion, ABCG2 c.421C>A polymorphism is associated with higher transfer of nifedipine to BM." @default.
- W2910040707 created "2019-01-25" @default.
- W2910040707 creator A5018165354 @default.
- W2910040707 creator A5031472796 @default.
- W2910040707 creator A5037941929 @default.
- W2910040707 creator A5052491986 @default.
- W2910040707 creator A5075704009 @default.
- W2910040707 creator A5090368891 @default.
- W2910040707 creator A5091879823 @default.
- W2910040707 date "2019-04-01" @default.
- W2910040707 modified "2023-10-16" @default.
- W2910040707 title "ABCG2 c.421C>A polymorphism alters nifedipine transport to breast milk in hypertensive breastfeeding women" @default.
- W2910040707 cites W1973844537 @default.
- W2910040707 cites W1977425813 @default.
- W2910040707 cites W1981078630 @default.
- W2910040707 cites W1982696778 @default.
- W2910040707 cites W1989061195 @default.
- W2910040707 cites W1990691323 @default.
- W2910040707 cites W2001852299 @default.
- W2910040707 cites W2005433404 @default.
- W2910040707 cites W2008548644 @default.
- W2910040707 cites W2014590100 @default.
- W2910040707 cites W2025695886 @default.
- W2910040707 cites W2030663513 @default.
- W2910040707 cites W2033020367 @default.
- W2910040707 cites W2037361383 @default.
- W2910040707 cites W2039299577 @default.
- W2910040707 cites W2048047193 @default.
- W2910040707 cites W2048536578 @default.
- W2910040707 cites W2050381784 @default.
- W2910040707 cites W2051167270 @default.
- W2910040707 cites W2051187390 @default.
- W2910040707 cites W2051835394 @default.
- W2910040707 cites W2052209393 @default.
- W2910040707 cites W2055924792 @default.
- W2910040707 cites W2070859235 @default.
- W2910040707 cites W2072025687 @default.
- W2910040707 cites W2074887652 @default.
- W2910040707 cites W2076436346 @default.
- W2910040707 cites W2079197876 @default.
- W2910040707 cites W2081207967 @default.
- W2910040707 cites W2093011419 @default.
- W2910040707 cites W2095908153 @default.
- W2910040707 cites W2117150909 @default.
- W2910040707 cites W2118094114 @default.
- W2910040707 cites W2119590603 @default.
- W2910040707 cites W2133287244 @default.
- W2910040707 cites W2140089141 @default.
- W2910040707 cites W2142024216 @default.
- W2910040707 cites W2147930289 @default.
- W2910040707 cites W2148154532 @default.
- W2910040707 cites W2171545201 @default.
- W2910040707 cites W2526796555 @default.
- W2910040707 cites W2566873639 @default.
- W2910040707 cites W2759415648 @default.
- W2910040707 cites W2759473504 @default.
- W2910040707 doi "https://doi.org/10.1016/j.reprotox.2019.01.007" @default.
- W2910040707 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30659932" @default.
- W2910040707 hasPublicationYear "2019" @default.
- W2910040707 type Work @default.
- W2910040707 sameAs 2910040707 @default.
- W2910040707 citedByCount "7" @default.
- W2910040707 countsByYear W29100407072019 @default.
- W2910040707 countsByYear W29100407072020 @default.
- W2910040707 countsByYear W29100407072021 @default.
- W2910040707 countsByYear W29100407072022 @default.
- W2910040707 crossrefType "journal-article" @default.
- W2910040707 hasAuthorship W2910040707A5018165354 @default.
- W2910040707 hasAuthorship W2910040707A5031472796 @default.
- W2910040707 hasAuthorship W2910040707A5037941929 @default.
- W2910040707 hasAuthorship W2910040707A5052491986 @default.
- W2910040707 hasAuthorship W2910040707A5075704009 @default.
- W2910040707 hasAuthorship W2910040707A5090368891 @default.
- W2910040707 hasAuthorship W2910040707A5091879823 @default.
- W2910040707 hasConcept C104317684 @default.
- W2910040707 hasConcept C121608353 @default.
- W2910040707 hasConcept C126322002 @default.
- W2910040707 hasConcept C134018914 @default.
- W2910040707 hasConcept C142724271 @default.
- W2910040707 hasConcept C149011108 @default.
- W2910040707 hasConcept C185592680 @default.
- W2910040707 hasConcept C2776283161 @default.
- W2910040707 hasConcept C2779066535 @default.
- W2910040707 hasConcept C44312359 @default.
- W2910040707 hasConcept C512196 @default.
- W2910040707 hasConcept C519063684 @default.
- W2910040707 hasConcept C530470458 @default.
- W2910040707 hasConcept C55493867 @default.
- W2910040707 hasConcept C71924100 @default.
- W2910040707 hasConcept C98274493 @default.
- W2910040707 hasConceptScore W2910040707C104317684 @default.
- W2910040707 hasConceptScore W2910040707C121608353 @default.
- W2910040707 hasConceptScore W2910040707C126322002 @default.
- W2910040707 hasConceptScore W2910040707C134018914 @default.
- W2910040707 hasConceptScore W2910040707C142724271 @default.
- W2910040707 hasConceptScore W2910040707C149011108 @default.
- W2910040707 hasConceptScore W2910040707C185592680 @default.
- W2910040707 hasConceptScore W2910040707C2776283161 @default.