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- W291006948 abstract "目的：探讨靶向Livin的RNA干扰对食管癌凋亡相关蛋白Caspase-3、Caspase-9的影响。方法：采用慢病毒载体转染Livin高表达的食管癌Eca-109细胞株,从而有效地进行靶向Livin的RNA干扰。分别采用实时荧光定量PCR和Western blot检测各组细胞中Livin、Caspase-3、Caspase-9 mRNA和蛋白表达情况。结果：与空白对照组和阴性组相比,实验组中Livin的mRNA及其蛋白的表达都明显降低（P〈0.01）,而Caspase-3和Caspase-9的mRNA及其蛋白的表达都明显增加（P〈0.01）。结论：针对Livin的RNA干扰可有效降低Livin高表达的食管癌Eca-109细胞株中Livin mRNA和蛋白水平。同时,与细胞凋亡相关的信号分子Caspase-3和Caspase-9 mRNA和蛋白水平均明显升高。" @default.
- W291006948 created "2016-06-24" @default.
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- W291006948 date "2011-01-01" @default.
- W291006948 modified "2023-09-23" @default.
- W291006948 title "靶向Livin的RNA干扰对食管癌Eca-109细胞凋亡相关蛋白Caspase-3和Caspase-9表达的影响" @default.
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