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- W2910079658 abstract "Abstract It has been demonstrated that miR-539 plays an important role in the development and progression of tumors. The purpose of this study was to analyze the correlation between the expression level of miR-539 and the clinicopathological features and prognosis of patients with pancreatic cancer. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze the expression level of miR-539 in 60 patients with pancreatic cancer. It was found that miR-539 gene expression was down-regulated in pancreatic cancer compared with that in paracancerous tissues. In addition, the expression level of miR-539 was inversely correlated with tumor differentiation (poorly to moderately differentiated vs . well differentiated, P =0.006), lymph node metastasis (positive vs . negative, P =0.006), clinical stage (III-IV vs . I-II, P =0.002), CA199 (≥200 vs . <200, P =0.019) and distant metastasis (positive vs . negative, P =0.035). The survival time of pancreatic cancer patients with low expression of miR-539 was significantly shorter than that of patients with high expression of miR-539. Multivariate analysis suggested that miR-539 expression level was an independent prognostic indicator for patients with pancreatic cancer ( P =0.025). Down-regulation of miR-539 may be a potentially unfavorable prognostic factor for patients with pancreatic cancer, and further studies are needed to confirm our conclusion in the future." @default.
- W2910079658 created "2019-01-25" @default.
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- W2910079658 date "2019-01-04" @default.
- W2910079658 modified "2023-09-23" @default.
- W2910079658 title "Down-regulation of miR-539 indicates poor prognosis in patients with pancreatic cancer" @default.
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- W2910079658 doi "https://doi.org/10.1515/biol-2018-0059" @default.
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