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• W2910106598 abstract "Event Abstract Back to Event Influence of Gestational Diabetes on Cognitive Function of the Adolescent Male/Female Offsprings Cini M. John1, 2, 3, Atish Prakash4, Nur Intan S. Yusof2, Aishah Adam2, Rajesh Ramasamy3 and Fazlin M. Fauzi2* 1 University of Calgary, Canada 2 Universiti Teknologi MARA Puncak Alam, Malaysia 3 Putra Malaysia University, Malaysia 4 Johns Hopkins Medicine, United States Background Maternal gestational diabetes has been proposed to negatively affect the cognitive abilities of the offspring. The underlying pathogenic mechanisms behind the abnormal cognitive risk profile in offsprings are unknown, but epigenetic changes induced by exposure to maternal hyperglycaemia and insulin resistance during gestation are implicated. Methods In this current study, 10-11 weeks old male/female offsprings of GDM rats and normal Sprague Dawley rats were used. Learning and memory functions, serum BDNF levels, structural changes in hippocampus were examined. To understand the immunological changes contributing to the functional effects in the brain, we analyzed subsets of T and B lymphocytes from splenocytes, circulating cytokines and anti/pro-inflammatory markers from brain. Results Our results show that mild impairment in learning and memory functions were observed in GDM offsprings, where they clocked a longer escape latency time and shorter time spent in target quadrant than the control groups however no significant difference were observed between male and female groups. Low BDNF levels were observed only in male offsprings. No structural changes were found in the normal layer organization in the hippocampus. Immune cell characterization revealed no significant changes in T or B cell populations, besides FOXP3+ regulatory T cells, which was high in the female offsprings along with anti-inflammatory cytokines IL-5, IL-10 and TGF-b. Pro/anti inflammatory markers IL-1beta, IL-12, IFN-γ and TNF-α, primary transcription factors NF-Kb didn’t show any changes between groups. There was a high expression of phosphoprotein p53 and IL-6 in male and female groups in the brain tissue of GDM offsprings. Conclusion In conclusion, these data demonstrate that mild cognitive impairment observed in the offsprings of GDM rats and were similar in male and female, however female offsprings are favoured while maintaining an anti-inflammatory environment in the brain tissues and circulation with expanded Treg cell population. It is important to further define and investigate sex differences in GDM influenced offspring’s metabolic and immune functions, which help to improve and optimize cognitive health and aid future research. Keywords: cognitive functions, GDM, male/female offspring, BDNF, Immune changes Conference: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”, Putrajaya, Malaysia, 3 Dec - 5 Feb, 2019. Presentation Type: Poster Presentation Topic: Metabolic diseases Citation: John CM, Prakash A, Yusof NS, Adam A, Ramasamy R and Fauzi FM (2019). Influence of Gestational Diabetes on Cognitive Function of the Adolescent Male/Female Offsprings. Front. Pharmacol. Conference Abstract: International Conference on Drug Discovery and Translational Medicine 2018 (ICDDTM '18) “Seizing Opportunities and Addressing Challenges of Precision Medicine”. doi: 10.3389/conf.fphar.2018.63.00015 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 12 Oct 2018; Published Online: 17 Jan 2019. * Correspondence: Dr. Fazlin M Fauzi, Universiti Teknologi MARA Puncak Alam, Selangor, Selangor, 42300, Malaysia, fazlin5465@puncakalam.uitm.edu.my Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Cini M John Atish Prakash Nur Intan S Yusof Aishah Adam Rajesh Ramasamy Fazlin M Fauzi Google Cini M John Atish Prakash Nur Intan S Yusof Aishah Adam Rajesh Ramasamy Fazlin M Fauzi Google Scholar Cini M John Atish Prakash Nur Intan S Yusof Aishah Adam Rajesh Ramasamy Fazlin M Fauzi PubMed Cini M John Atish Prakash Nur Intan S Yusof Aishah Adam Rajesh Ramasamy Fazlin M Fauzi Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2910106598 title "Influence of Gestational Diabetes on Cognitive Function of the Adolescent Male/Female Offsprings" @default.
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