FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910130757> ?p ?o ?g. }

• W2910130757 abstract "The continual reassessment method (CRM) is a model-based design for phase I trials, which aims to find the maximum tolerated dose (MTD) of a new therapy. The CRM has been shown to be more accurate in targeting the MTD than traditional rule-based approaches such as the 3 + 3 design, which is used in most phase I trials. Furthermore, the CRM has been shown to assign more trial participants at or close to the MTD than the 3 + 3 design. However, the CRM’s uptake in clinical research has been incredibly slow, putting trial participants, drug development and patients at risk. Barriers to increasing the use of the CRM have been identified, most notably a lack of knowledge amongst clinicians and statisticians on how to apply new designs in practice. No recent tutorial, guidelines, or recommendations for clinicians on conducting dose-finding studies using the CRM are available. Furthermore, practical resources to support clinicians considering the CRM for their trials are scarce. To help overcome these barriers, we present a structured framework for designing a dose-finding study using the CRM. We give recommendations for key design parameters and advise on conducting pre-trial simulation work to tailor the design to a specific trial. We provide practical tools to support clinicians and statisticians, including software recommendations, and template text and tables that can be edited and inserted into a trial protocol. We also give guidance on how to conduct and report dose-finding studies using the CRM. An initial set of design recommendations are provided to kick-start the design process. To complement these and the additional resources, we describe two published dose-finding trials that used the CRM. We discuss their designs, how they were conducted and analysed, and compare them to what would have happened under a 3 + 3 design. The framework and resources we provide are aimed at clinicians and statisticians new to the CRM design. Provision of key resources in this contemporary guidance paper will hopefully improve the uptake of the CRM in phase I dose-finding trials." @default.
• W2910130757 created "2019-01-25" @default.
• W2910130757 creator A5001137904 @default.
• W2910130757 creator A5004036274 @default.
• W2910130757 creator A5019472985 @default.
• W2910130757 creator A5028677250 @default.
• W2910130757 creator A5038778256 @default.
• W2910130757 creator A5051267341 @default.
• W2910130757 creator A5052024539 @default.
• W2910130757 creator A5053252382 @default.
• W2910130757 creator A5055843680 @default.
• W2910130757 creator A5057024394 @default.
• W2910130757 creator A5059442508 @default.
• W2910130757 creator A5091775829 @default.
• W2910130757 date "2019-01-18" @default.
• W2910130757 modified "2023-10-10" @default.
• W2910130757 title "How to design a dose-finding study using the continual reassessment method" @default.
• W2910130757 cites W1491499215 @default.
• W2910130757 cites W157796586 @default.
• W2910130757 cites W1890147619 @default.
• W2910130757 cites W1951041815 @default.
• W2910130757 cites W1971341357 @default.
• W2910130757 cites W1976397576 @default.
• W2910130757 cites W1978972668 @default.
• W2910130757 cites W1996262958 @default.
• W2910130757 cites W1996660434 @default.
• W2910130757 cites W1999606024 @default.
• W2910130757 cites W2000870000 @default.
• W2910130757 cites W2001278210 @default.
• W2910130757 cites W2002952151 @default.
• W2910130757 cites W2002981832 @default.
• W2910130757 cites W2006990152 @default.
• W2910130757 cites W2007276247 @default.
• W2910130757 cites W2009640726 @default.
• W2910130757 cites W2012307210 @default.
• W2910130757 cites W2012316898 @default.
• W2910130757 cites W2015891043 @default.
• W2910130757 cites W2024938615 @default.
• W2910130757 cites W2029024886 @default.
• W2910130757 cites W2041278781 @default.
• W2910130757 cites W2042175068 @default.
• W2910130757 cites W2042990006 @default.
• W2910130757 cites W2053419196 @default.
• W2910130757 cites W2059627117 @default.
• W2910130757 cites W2064122822 @default.
• W2910130757 cites W2073911899 @default.
• W2910130757 cites W2075548747 @default.
• W2910130757 cites W2076108528 @default.
• W2910130757 cites W2076904060 @default.
• W2910130757 cites W2082105321 @default.
• W2910130757 cites W2087126873 @default.
• W2910130757 cites W2093423617 @default.
• W2910130757 cites W2095834693 @default.
• W2910130757 cites W2095967516 @default.
• W2910130757 cites W2098980231 @default.
• W2910130757 cites W2103105040 @default.
• W2910130757 cites W2103899120 @default.
• W2910130757 cites W2108441636 @default.
• W2910130757 cites W2111744858 @default.
• W2910130757 cites W2115499099 @default.
• W2910130757 cites W2115930553 @default.
• W2910130757 cites W2121660184 @default.
• W2910130757 cites W2125300671 @default.
• W2910130757 cites W2128843352 @default.
• W2910130757 cites W2132254057 @default.
• W2910130757 cites W2139494088 @default.
• W2910130757 cites W2142661912 @default.
• W2910130757 cites W2144946553 @default.
• W2910130757 cites W2147051968 @default.
• W2910130757 cites W2147322164 @default.
• W2910130757 cites W2148829424 @default.
• W2910130757 cites W2149344761 @default.
• W2910130757 cites W2151413410 @default.
• W2910130757 cites W2158740848 @default.
• W2910130757 cites W2160796820 @default.
• W2910130757 cites W2162300921 @default.
• W2910130757 cites W2166992787 @default.
• W2910130757 cites W2167228337 @default.
• W2910130757 cites W2170201242 @default.
• W2910130757 cites W2171242595 @default.
• W2910130757 cites W2173701885 @default.
• W2910130757 cites W2254732903 @default.
• W2910130757 cites W2312270541 @default.
• W2910130757 cites W2315885933 @default.
• W2910130757 cites W2339302618 @default.
• W2910130757 cites W2344619281 @default.
• W2910130757 cites W2473193831 @default.
• W2910130757 cites W2491105136 @default.
• W2910130757 cites W2531747846 @default.
• W2910130757 cites W2586405436 @default.
• W2910130757 cites W2587924023 @default.
• W2910130757 cites W2619182341 @default.
• W2910130757 cites W2736865832 @default.
• W2910130757 cites W2738408027 @default.
• W2910130757 cites W2778068191 @default.
• W2910130757 cites W2791409969 @default.
• W2910130757 cites W2796119125 @default.
• W2910130757 cites W2983657182 @default.
• W2910130757 cites W3103950165 @default.
• W2910130757 cites W603816075 @default.

• next