FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910152169> ?p ?o ?g. }

• W2910152169 endingPage "1472" @default.
• W2910152169 startingPage "1462" @default.
• W2910152169 abstract "OBJECTIVE The aim of this study was to evaluate the safety and clinical outcomes associated with stereotactic surgical implantation of modified bone marrow–derived mesenchymal stem cells (SB623) in patients with stable chronic ischemic stroke. METHODS This was a 2-year, open-label, single-arm, phase 1/2a study; the selected patients had chronic motor deficits between 6 and 60 months after nonhemorrhagic stroke. SB623 cells were administered to the target sites surrounding the subcortical stroke region using MRI stereotactic image guidance. RESULTS A total of 18 patients were treated with SB623 cells. All experienced at least 1 treatment-emergent adverse event (TEAE). No patients withdrew due to adverse events, and there were no dose-limiting toxicities or deaths. The most frequent TEAE was headache related to the surgical procedure (88.9%). Seven patients experienced 9 serious adverse events, which resolved without sequelae. In 16 patients who completed 24 months of treatment, statistically significant improvements from baseline (mean) at 24 months were reported for the European Stroke Scale (ESS) score, 5.7 (95% CI 1.4–10.1, p < 0.05); National Institutes of Health Stroke Scale (NIHSS) score, −2.1 (95% CI −3.3 to −1.0, p < 0.01), Fugl-Meyer (F-M) total score, 19.4 (95% CI 9.9–29.0, p < 0.01); and F-M motor scale score, 10.4 (95% CI 4.0–16.7, p < 0.01). Measures of efficacy reached plateau by 12 months with no decline thereafter. There were no statistically significant changes in the modified Rankin Scale score. The size of transient lesions detected by T2-weighted FLAIR imaging in the ipsilateral cortex at weeks 1–2 postimplantation significantly correlated with improvement in ESS (0.619, p < 0.05) and NIHSS (−0.735, p < 0.01) scores at 24 months. CONCLUSIONS In this completed 2-year phase 1/2a study, implantation of SB623 cells in patients with stable chronic stroke was safe and was accompanied by improvements in clinical outcomes. Clinical trial registration no.: NCT01287936 (clinicaltrials.gov)" @default.
• W2910152169 created "2019-01-25" @default.
• W2910152169 creator A5012532424 @default.
• W2910152169 creator A5014374296 @default.
• W2910152169 creator A5020032572 @default.
• W2910152169 creator A5020726836 @default.
• W2910152169 creator A5020743917 @default.
• W2910152169 creator A5030896761 @default.
• W2910152169 creator A5046883964 @default.
• W2910152169 creator A5047951503 @default.
• W2910152169 creator A5052007700 @default.
• W2910152169 creator A5059544195 @default.
• W2910152169 creator A5072569216 @default.
• W2910152169 creator A5086485786 @default.
• W2910152169 date "2019-11-01" @default.
• W2910152169 modified "2023-10-17" @default.
• W2910152169 title "Two-year safety and clinical outcomes in chronic ischemic stroke patients after implantation of modified bone marrow–derived mesenchymal stem cells (SB623): a phase 1/2a study" @default.
• W2910152169 cites W1981399914 @default.
• W2910152169 cites W1989770968 @default.
• W2910152169 cites W1991719688 @default.
• W2910152169 cites W2007543609 @default.
• W2910152169 cites W2011333730 @default.
• W2910152169 cites W2015868407 @default.
• W2910152169 cites W2036909109 @default.
• W2910152169 cites W2056068526 @default.
• W2910152169 cites W2064301927 @default.
• W2910152169 cites W2064704194 @default.
• W2910152169 cites W2072110652 @default.
• W2910152169 cites W2078959369 @default.
• W2910152169 cites W2080504768 @default.
• W2910152169 cites W2083958711 @default.
• W2910152169 cites W2087874301 @default.
• W2910152169 cites W2093072754 @default.
• W2910152169 cites W2098661447 @default.
• W2910152169 cites W2107555007 @default.
• W2910152169 cites W2115949595 @default.
• W2910152169 cites W2118660285 @default.
• W2910152169 cites W2122897710 @default.
• W2910152169 cites W2131708822 @default.
• W2910152169 cites W2147800731 @default.
• W2910152169 cites W2161719272 @default.
• W2910152169 cites W2162285676 @default.
• W2910152169 cites W2167156037 @default.
• W2910152169 cites W2169093550 @default.
• W2910152169 cites W2189726121 @default.
• W2910152169 cites W2193935440 @default.
• W2910152169 cites W2319110106 @default.
• W2910152169 cites W2325155086 @default.
• W2910152169 cites W2343476684 @default.
• W2910152169 cites W236978204 @default.
• W2910152169 cites W2414102005 @default.
• W2910152169 cites W2473522608 @default.
• W2910152169 cites W2490585184 @default.
• W2910152169 cites W2564907072 @default.
• W2910152169 cites W2580792129 @default.
• W2910152169 cites W3150640494 @default.
• W2910152169 doi "https://doi.org/10.3171/2018.5.jns173147" @default.
• W2910152169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30497166" @default.
• W2910152169 hasPublicationYear "2019" @default.
• W2910152169 type Work @default.
• W2910152169 sameAs 2910152169 @default.
• W2910152169 citedByCount "67" @default.
• W2910152169 countsByYear W29101521692019 @default.
• W2910152169 countsByYear W29101521692020 @default.
• W2910152169 countsByYear W29101521692021 @default.
• W2910152169 countsByYear W29101521692022 @default.
• W2910152169 countsByYear W29101521692023 @default.
• W2910152169 crossrefType "journal-article" @default.
• W2910152169 hasAuthorship W2910152169A5012532424 @default.
• W2910152169 hasAuthorship W2910152169A5014374296 @default.
• W2910152169 hasAuthorship W2910152169A5020032572 @default.
• W2910152169 hasAuthorship W2910152169A5020726836 @default.
• W2910152169 hasAuthorship W2910152169A5020743917 @default.
• W2910152169 hasAuthorship W2910152169A5030896761 @default.
• W2910152169 hasAuthorship W2910152169A5046883964 @default.
• W2910152169 hasAuthorship W2910152169A5047951503 @default.
• W2910152169 hasAuthorship W2910152169A5052007700 @default.
• W2910152169 hasAuthorship W2910152169A5059544195 @default.
• W2910152169 hasAuthorship W2910152169A5072569216 @default.
• W2910152169 hasAuthorship W2910152169A5086485786 @default.
• W2910152169 hasBestOaLocation W29101521691 @default.
• W2910152169 hasConcept C126322002 @default.
• W2910152169 hasConcept C127413603 @default.
• W2910152169 hasConcept C141071460 @default.
• W2910152169 hasConcept C142724271 @default.
• W2910152169 hasConcept C1862650 @default.
• W2910152169 hasConcept C197934379 @default.
• W2910152169 hasConcept C198826908 @default.
• W2910152169 hasConcept C2776581026 @default.
• W2910152169 hasConcept C2776694085 @default.
• W2910152169 hasConcept C2778818304 @default.
• W2910152169 hasConcept C2780007613 @default.
• W2910152169 hasConcept C2780645631 @default.
• W2910152169 hasConcept C3018579778 @default.
• W2910152169 hasConcept C3020199598 @default.
• W2910152169 hasConcept C541997718 @default.
• W2910152169 hasConcept C71924100 @default.
• W2910152169 hasConcept C78519656 @default.

• next