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- W2910158105 abstract "Background Serological biomarkers with ability to predict outcome and therapeutic response of patients might be helpful in introducing the concept of treat-to-target into management of juvenile idiopathic arthritis (JIA). Among others, calprotectin (S100A8A9) and calgranulin C (S100A12) are considered to be valuable markers of disease activity and risk factors for flare after withdrawal of treatment. Vascular endothelial cadherin (VE-cadherin) is a marker of endothelial permeability which has been postulated to predict response to methotrexate therapy in rheumatoid arthritis (RA) patients. Objectives The aim of the study was to assess the clinical significance of measuring serum concentrations of S100A8A9, S100A12 and VE-cadherin in patients with freshly diagnosed JIA and those with exacerbated course of the disease. Methods Serum levels of the listed biomarkers were determined in 30 patients diagnosed with JIA and 21 age- and sex-matched healthy controls. In the study group blood samples were obtained in two time points in order to evaluate dynamics of concentrations of markers. Results S100A8A9 and S100A12 serum concentrations at baseline were positively correlated with ESR at second time point (r=0.378 and 0.425, p=0.0397 and 0.0193, respectively). S100A12 had equal correlation with CRP at second time point (r=0.391, p=0.0329). Patients freshly diagnosed with JIA had higher levels of S100A12 (8.49±4.92 ng/ml vs. 5.49±2.21 ng/ml, p=0.007) and VE-cadherin (5.31±1.13 ng/ml vs. 3.50±0.58 ng/ml, p Conclusions Presented study group needs to be expanded with more patients, especially with minimal disease activity, in order to validate demonstrated preliminary results. VE-cadherin may be considered as a future diagnostic biomarker, however its specificity requires detailed assessment. S100A8A9 and S100A12 merit further evaluation as potential prognostic biomarkers for more aggressive course of the disease. Disclosure of Interest None declared" @default.
- W2910158105 created "2019-01-25" @default.
- W2910158105 creator A5009579378 @default.
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- W2910158105 date "2018-06-01" @default.
- W2910158105 modified "2023-09-23" @default.
- W2910158105 title "THU0585 Personalised treatment in juvenile idiopathic arthritis – future or fiction? preliminary results of using s100a8a9, s100a12 and vascular endothelial cadherin as diagnostic and prognostic biomarkers" @default.
- W2910158105 doi "https://doi.org/10.1136/annrheumdis-2018-eular.2440" @default.
- W2910158105 hasPublicationYear "2018" @default.
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