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- W2910162201 abstract "Anti- tumor vaccination elicits imperfect immune responses against tumor cells; that is related to the presence of suppressive obstacles in the tumor microenvironment. The main members of suppressive milieu of tumor are heteroogenous groups of immune cells in which regulatory T cell is a substantial component. Tregs express different immunomodulatory molecules such as FoxP3. Transcription factor, FoxP3, is a specific intracellular marker of Treg and crucial for Treg development. Therefore it is an attractive target for cancer treatment. This article reviews some recent anti-Treg vaccine focusing on FoxP3 to ameliorate anti-tumor immune responses. Among them, fusion vaccine of FoxP3-Fc(IgG) recombinant DNA vaccine and its accordant protein vaccine represents effective results." @default.
- W2910162201 created "2019-01-25" @default.
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- W2910162201 date "2019-01-30" @default.
- W2910162201 modified "2023-10-16" @default.
- W2910162201 title "Anti-regulatory T cell vaccines in immunotherapy: focusing on FoxP3 as target" @default.
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- W2910162201 doi "https://doi.org/10.1080/21645515.2018.1545625" @default.
- W2910162201 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6605713" @default.
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