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- W2910258353 abstract "Background Rheumatoid arthritis (RA) is a chromic, autoimmune and inflammatory joint disease with a poorly understood etiology. Despite widespread diagnostic use of anti-citrullinated protein antibodies and rheumatoid factor, there is strong demand for novel biomarkers to improve the diagnosis this disease. Objectives The purpose of present study is to investigate novel autoantibodies in the synovial fluid of RA patients. Methods 1) By using SEREX (Serological identification of antigens by recombinant cDNA expression cloning), we identified ten and several antigens from sera of RA patients. 2) Three epitope sites in the candidate antigens proteins were predicted and 18 mer peptides were synthesised. 3) Synovial fluid of the knees was obtained from 48 RA and 48 osteoarthritis (OA) patients. 4) Furthermore, AlphaLISA was used to analyse the antibody levels in synovial fluid using synthetic polypeptide as antigens. Results Significantly higher proportion of antibodies against lamin A (LMNA, RA 19871+13924 VS OA 6726+3975, p Conclusions We identified two novel autoantibodies in the knee synovial fluid of RA patients. These antibodies would have the potential to become diagnostic biomarkers of RA. References [1] Taimen P, Pfleghaar K, Shimi T, et al. A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization. Proc Natl Acad Sci U S2009;106:20788–93. [2] Su L, Hershberger RJ, and Weissman IL. LYAR, a nobel nucleolar protein with zinc finger DNA-binding mitifs, is involved in cell growth regulation. Genes Dev1993;7:735–48. Disclosure of Interest None declared" @default.
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- W2910258353 date "2018-06-01" @default.
- W2910258353 modified "2023-09-23" @default.
- W2910258353 title "THU0081 Identification of novel autoantibodies in the synovial fluid from patients with rheumatoid arthritis" @default.
- W2910258353 doi "https://doi.org/10.1136/annrheumdis-2018-eular.3257" @default.
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