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• W2910261752 endingPage "678" @default.
• W2910261752 startingPage "663" @default.
• W2910261752 abstract "MicroRNAs (miRNAs) are important posttranscriptional regulators of gene expression. However, comprehensive expression profiles of miRNAs during mammalian spermatogenesis are lacking. Herein, we sequenced small RNAs in highly purified mouse spermatogenic cells at different stages. We found that a family of X-linked miRNAs named spermatogenesis-related miRNAs (spermiRs) is predominantly expressed in the early meiotic phases and has a conserved testis-specific high expression pattern in different mammals. We identified one spermiR homolog in opossum; this homolog might originate from THER1, a retrotransposon that is active in marsupials but extinct in current placental mammals. SpermiRs have expanded rapidly with mammalian evolution and are diverged into two clades, spermiR-L and spermiR-R, which are likely to have been generated at least in part by tandem duplication mediated by flanking retrotransposable elements. Notably, despite having undergone highly frequent lineage-specific duplication events, the sequences encoding all spermiR family members are strictly located between two protein-coding genes, Slitrk2 and Fmr1. Moreover, spermiR-Ls and spermiR-Rs have evolved different expression patterns during spermatogenesis in different mammals. Intriguingly, the seed sequences of spermiRs, which are critical for the recognition of target genes, are highly divergent within and among mammals, whereas spermiR target genes largely overlap. When miR-741, the most highly expressed spermiR, is knocked out in cultured mouse spermatogonial stem cells (SSCs), another spermiR, miR-465a-5p, is dramatically upregulated and becomes the most abundant miRNA. Notably, miR-741−/− SSCs grow normally, and the genome-wide expression levels of mRNAs remain unchanged. All these observations indicate functional compensation between spermiR family members and strong coevolution between spermiRs and their targets." @default.
• W2910261752 created "2019-01-25" @default.
• W2910261752 creator A5008631138 @default.
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• W2910261752 date "2019-01-14" @default.
• W2910261752 modified "2023-10-17" @default.
• W2910261752 title "Evolution of an X-Linked miRNA Family Predominantly Expressed in Mammalian Male Germ Cells" @default.
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• W2910261752 cites W1833434068 @default.
• W2910261752 cites W1912079946 @default.
• W2910261752 cites W1964631913 @default.
• W2910261752 cites W1967832728 @default.
• W2910261752 cites W1968421082 @default.
• W2910261752 cites W1971771310 @default.
• W2910261752 cites W1976820865 @default.
• W2910261752 cites W1977733607 @default.
• W2910261752 cites W1983080781 @default.
• W2910261752 cites W1986934385 @default.
• W2910261752 cites W1987245339 @default.
• W2910261752 cites W1991312188 @default.
• W2910261752 cites W1993491850 @default.
• W2910261752 cites W1994420360 @default.
• W2910261752 cites W1996521832 @default.
• W2910261752 cites W2000945483 @default.
• W2910261752 cites W2007612364 @default.
• W2910261752 cites W2009638710 @default.
• W2910261752 cites W2010329731 @default.
• W2910261752 cites W2012453729 @default.
• W2910261752 cites W2017426710 @default.
• W2910261752 cites W2019623019 @default.
• W2910261752 cites W2029532148 @default.
• W2910261752 cites W2030822125 @default.
• W2910261752 cites W2033049603 @default.
• W2910261752 cites W2035930185 @default.
• W2910261752 cites W2037055772 @default.
• W2910261752 cites W2040605613 @default.
• W2910261752 cites W2040975355 @default.
• W2910261752 cites W2053834034 @default.
• W2910261752 cites W2055043387 @default.
• W2910261752 cites W2055821541 @default.
• W2910261752 cites W2059173951 @default.
• W2910261752 cites W2062288798 @default.
• W2910261752 cites W2063535371 @default.
• W2910261752 cites W2065426290 @default.
• W2910261752 cites W2069408870 @default.
• W2910261752 cites W2071709406 @default.
• W2910261752 cites W2075168304 @default.
• W2910261752 cites W2085151059 @default.
• W2910261752 cites W2089001645 @default.
• W2910261752 cites W2094177946 @default.
• W2910261752 cites W2096001522 @default.
• W2910261752 cites W2096939566 @default.
• W2910261752 cites W2099485194 @default.
• W2910261752 cites W2099715131 @default.
• W2910261752 cites W2101681543 @default.
• W2910261752 cites W2103012554 @default.
• W2910261752 cites W2103195302 @default.
• W2910261752 cites W2106882534 @default.
• W2910261752 cites W2114216199 @default.
• W2910261752 cites W2115003697 @default.
• W2910261752 cites W2117260150 @default.
• W2910261752 cites W2121487483 @default.
• W2910261752 cites W2124578478 @default.
• W2910261752 cites W2124584349 @default.
• W2910261752 cites W2124985265 @default.
• W2910261752 cites W2132632499 @default.
• W2910261752 cites W2133894023 @default.
• W2910261752 cites W2135537195 @default.
• W2910261752 cites W2136439471 @default.
• W2910261752 cites W2140694202 @default.
• W2910261752 cites W2141157874 @default.
• W2910261752 cites W2142668377 @default.
• W2910261752 cites W2144630164 @default.
• W2910261752 cites W2149785901 @default.
• W2910261752 cites W2153749888 @default.
• W2910261752 cites W2161248563 @default.
• W2910261752 cites W2162674813 @default.
• W2910261752 cites W2162716521 @default.
• W2910261752 cites W2163091657 @default.
• W2910261752 cites W2165064122 @default.
• W2910261752 cites W2165764599 @default.
• W2910261752 cites W2201382378 @default.
• W2910261752 cites W2409344943 @default.
• W2910261752 cites W4234021236 @default.
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• W2910261752 doi "https://doi.org/10.1093/molbev/msz001" @default.
• W2910261752 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6445303" @default.
• W2910261752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30649414" @default.
• W2910261752 hasPublicationYear "2019" @default.
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