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• W2910266901 abstract "Atherosclerosis is the leading cause of stroke and death worldwide. Although many lipid-lowering or antiplatelet medicines have been used to prevent the devastating outcomes caused by atherosclerosis, the serious side effects of these medicines cannot be ignored. Moreover, these medicines are aimed at preventing end-point events rather than addressing the formation and progression of the lesion. Rapamycin (sirolimus), a fermentation product derived from soil samples, has immunosuppressive and anti-proliferation effects. It is an inhibitor of mammalian targets of rapamycin, thereby stimulating autophagy pathways. Several lines of evidence have demonstrated that rapamycin possess multiple protective effects against atherosclerosis through various molecular mechanisms. Moreover, it has been used successfully as an anti-proliferation agent to prevent in-stent restenosis or vascular graft stenosis in patients with coronary artery disease. A thorough understanding of the biomedical regulatory mechanism of rapamycin in atherosclerosis might reveal pathways for retarding atherosclerosis. This review summarizes the current knowledge of biomedical mechanisms by which rapamycin retards atherosclerosis through action on various cells (endothelial cells, macrophages, vascular smooth muscle cells, and T-cells) in early and advanced atherosclerosis and describes clinical and potential clinical applications of the agent." @default.
• W2910266901 created "2019-01-25" @default.
• W2910266901 creator A5018557242 @default.
• W2910266901 creator A5019339956 @default.
• W2910266901 creator A5060062270 @default.
• W2910266901 creator A5084030316 @default.
• W2910266901 date "2019-01-07" @default.
• W2910266901 modified "2023-10-01" @default.
• W2910266901 title "Rapamycin: A Bacteria-Derived Immunosuppressant That Has Anti-atherosclerotic Effects and Its Clinical Application" @default.
• W2910266901 cites W139644270 @default.
• W2910266901 cites W1550130287 @default.
• W2910266901 cites W1554030075 @default.
• W2910266901 cites W1757715844 @default.
• W2910266901 cites W1849785625 @default.
• W2910266901 cites W1857442038 @default.
• W2910266901 cites W192738711 @default.
• W2910266901 cites W1965072977 @default.
• W2910266901 cites W1966025802 @default.
• W2910266901 cites W1968444524 @default.
• W2910266901 cites W1969796049 @default.
• W2910266901 cites W1983150061 @default.
• W2910266901 cites W1985020333 @default.
• W2910266901 cites W1986757474 @default.
• W2910266901 cites W1988623729 @default.
• W2910266901 cites W1989605865 @default.
• W2910266901 cites W1993009006 @default.
• W2910266901 cites W1998792752 @default.
• W2910266901 cites W1999209934 @default.
• W2910266901 cites W1999579644 @default.
• W2910266901 cites W2003202258 @default.
• W2910266901 cites W2003965774 @default.
• W2910266901 cites W2006336603 @default.
• W2910266901 cites W2007313176 @default.
• W2910266901 cites W2008298117 @default.
• W2910266901 cites W2011826559 @default.
• W2910266901 cites W2017335473 @default.
• W2910266901 cites W2017411331 @default.
• W2910266901 cites W2022570265 @default.
• W2910266901 cites W2028536701 @default.
• W2910266901 cites W2033883349 @default.
• W2910266901 cites W2035935157 @default.
• W2910266901 cites W2037141618 @default.
• W2910266901 cites W2038631789 @default.
• W2910266901 cites W2046051570 @default.
• W2910266901 cites W2046986284 @default.
• W2910266901 cites W2059333451 @default.
• W2910266901 cites W2062643000 @default.
• W2910266901 cites W2070972183 @default.
• W2910266901 cites W2072738456 @default.
• W2910266901 cites W2075460603 @default.
• W2910266901 cites W2075726931 @default.
• W2910266901 cites W2079315105 @default.
• W2910266901 cites W2079818105 @default.
• W2910266901 cites W2081403498 @default.
• W2910266901 cites W2084941491 @default.
• W2910266901 cites W2087582854 @default.
• W2910266901 cites W2092146409 @default.
• W2910266901 cites W2094667242 @default.
• W2910266901 cites W2095001136 @default.
• W2910266901 cites W2096164842 @default.
• W2910266901 cites W2101624540 @default.
• W2910266901 cites W2102187172 @default.
• W2910266901 cites W2102267538 @default.
• W2910266901 cites W2104394381 @default.
• W2910266901 cites W2106685274 @default.
• W2910266901 cites W2107233004 @default.
• W2910266901 cites W2107784979 @default.
• W2910266901 cites W2109884285 @default.
• W2910266901 cites W2110352874 @default.
• W2910266901 cites W2112992011 @default.
• W2910266901 cites W2115072188 @default.
• W2910266901 cites W2123035588 @default.
• W2910266901 cites W2124668346 @default.
• W2910266901 cites W2126493366 @default.
• W2910266901 cites W2127483273 @default.
• W2910266901 cites W2135500248 @default.
• W2910266901 cites W2135804517 @default.
• W2910266901 cites W2137111279 @default.
• W2910266901 cites W2140680553 @default.
• W2910266901 cites W2142304810 @default.
• W2910266901 cites W2143786800 @default.
• W2910266901 cites W2146743728 @default.
• W2910266901 cites W2149753712 @default.
• W2910266901 cites W2150350943 @default.
• W2910266901 cites W2151105229 @default.
• W2910266901 cites W2151485523 @default.
• W2910266901 cites W2157280773 @default.
• W2910266901 cites W2160889224 @default.
• W2910266901 cites W2165441306 @default.
• W2910266901 cites W2166219311 @default.
• W2910266901 cites W2166685519 @default.
• W2910266901 cites W2171284332 @default.
• W2910266901 cites W2181644149 @default.
• W2910266901 cites W2222218603 @default.
• W2910266901 cites W2238666922 @default.
• W2910266901 cites W2254581432 @default.
• W2910266901 cites W2274924551 @default.
• W2910266901 cites W2276012049 @default.
• W2910266901 cites W2319932477 @default.
• W2910266901 cites W2328714191 @default.

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