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- W2910273753 abstract "Apple is a rich source of bioactive phytochemicals that help improve health by preventing and/or curing many disease processes, including cancer. One of the apple polyphenols is phloretin [2',4',6'-Trihydroxy-3-(4-hydroxyphenyl)-propiophenone], which has been widely investigated for its antioxidant, anti-inflammatory and anti-cancer activities in a wide array of preclinical studies. The efficacy of phloretin in suppressing xenograft tumor growth in athymic nude mice implanted with a variety of human cancer cells, and the ability of the compound to interfere with cancer cells signaling, have made it a promising candidate for anti-cancer drug development. Mechanistically, phloretin has been reported to arrest the growth of tumor cells by blocking cyclins and cyclin-dependent kinases and induce apoptosis by activating mitochondria-mediated cell death. The blockade of the glycolytic pathway via downregulation of GLUT2 mRNA and proteins, and the inhibition of tumor cells migration, also corroborates the anti-cancer effects of phloretin. This review sheds light on the molecular targets of phloretin as a potential anti-cancer and anti-inflammatory natural agent." @default.
- W2910273753 created "2019-01-25" @default.
- W2910273753 creator A5037799804 @default.
- W2910273753 date "2019-01-13" @default.
- W2910273753 modified "2023-10-16" @default.
- W2910273753 title "Biochemical Basis of Anti-Cancer-Effects of Phloretin—A Natural Dihydrochalcone" @default.
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- W2910273753 doi "https://doi.org/10.3390/molecules24020278" @default.
- W2910273753 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6359539" @default.
- W2910273753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30642127" @default.
- W2910273753 hasPublicationYear "2019" @default.
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