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- W2910305526 abstract "The mitotic spindle is an ensemble of microtubules responsible for the repartition of the chromosomal content between the two daughter cells during division. In metazoans, spindle assembly is a gradual process involving dynamic microtubules and recruitment of numerous associated proteins and motors. During mitosis, centrosomes organize and nucleate the majority of spindle microtubules. In contrast, oocytes lack canonical centrosomes but are still able to form bipolar spindles, starting from an initial ball that self-organizes in several hours. Interfering with early steps of meiotic spindle assembly can lead to erroneous chromosome segregation. Although not fully elucidated, this process is known to rely on antagonistic activities of plus end– and minus end–directed motors. We developed a model of early meiotic spindle assembly in mouse oocytes, including key factors such as microtubule dynamics and chromosome movement. We explored how the balance between plus end– and minus end–directed motors, as well as the influence of microtubule nucleation, impacts spindle morphology. In a refined model, we added spatial regulation of microtubule stability and minus-end clustering. We could reproduce the features of early stages of spindle assembly from 12 different experimental perturbations and predict eight additional perturbations. With its ability to characterize and predict chromosome individualization, this model can help deepen our understanding of spindle assembly." @default.
- W2910305526 created "2019-01-25" @default.
- W2910305526 creator A5017317489 @default.
- W2910305526 creator A5041023973 @default.
- W2910305526 creator A5054027067 @default.
- W2910305526 creator A5062039839 @default.
- W2910305526 creator A5078123319 @default.
- W2910305526 creator A5087067085 @default.
- W2910305526 date "2019-03-21" @default.
- W2910305526 modified "2023-10-02" @default.
- W2910305526 title "A computational model of the early stages of acentriolar meiotic spindle assembly" @default.
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