Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910307871> ?p ?o ?g. }
- W2910307871 endingPage "184" @default.
- W2910307871 startingPage "177" @default.
- W2910307871 abstract "With aging, various factors deteriorate the normal sleep process that is essential for the restoration of functional and physical performance. Due to aging-related diseases, life changes, or aging itself, disturbances in normal sleep cycles can profoundly affect healthy aging. To understand the interconnections between aging and the factors influencing sleep, with emerging evidence accumulated in recent years, this study elaborates on the roles of aging in sleep from four perspectives: cortical thinning, white matter degeneration, neurotransmitter dysregulation, and circadian disorganization. In brief, with aging, cortical thinning can be induced by the deposition of neurotoxic substances, and white matter degeneration can be induced by vascular abnormalities. These alterations emerging in the brain jointly disrupt sleep spindles and slow waves, leading to sleep disturbances. Age-related dysregulation in neurotransmitters (including galanin, orexin, serotonin, and adenosine) directly impairs the sleep modulation system. Disorganization in the circadian system consisting of suprachiasmatic nucleus dysfunction, reduced light transmission, and local circadian clock disruption collectively interrupts circadian rhythms, also causing sleep disturbances in the older. Of note is the bidirectional relationship between aging and sleep, which required us to examine this issue from different perspectives." @default.
- W2910307871 created "2019-01-25" @default.
- W2910307871 creator A5032117360 @default.
- W2910307871 creator A5035683886 @default.
- W2910307871 creator A5036043170 @default.
- W2910307871 creator A5039904219 @default.
- W2910307871 creator A5041693797 @default.
- W2910307871 creator A5044056640 @default.
- W2910307871 creator A5054209152 @default.
- W2910307871 creator A5055174519 @default.
- W2910307871 creator A5077904151 @default.
- W2910307871 creator A5080834198 @default.
- W2910307871 creator A5082058489 @default.
- W2910307871 date "2019-03-01" @default.
- W2910307871 modified "2023-10-14" @default.
- W2910307871 title "Roles of aging in sleep" @default.
- W2910307871 cites W1492755669 @default.
- W2910307871 cites W1545353838 @default.
- W2910307871 cites W1551543102 @default.
- W2910307871 cites W1559360095 @default.
- W2910307871 cites W1590813564 @default.
- W2910307871 cites W1634462108 @default.
- W2910307871 cites W1969904423 @default.
- W2910307871 cites W1970709955 @default.
- W2910307871 cites W1971729817 @default.
- W2910307871 cites W1972570954 @default.
- W2910307871 cites W1973117088 @default.
- W2910307871 cites W1974936856 @default.
- W2910307871 cites W1977518394 @default.
- W2910307871 cites W1985113193 @default.
- W2910307871 cites W1986024270 @default.
- W2910307871 cites W1988394934 @default.
- W2910307871 cites W1990378956 @default.
- W2910307871 cites W2000693195 @default.
- W2910307871 cites W2001617007 @default.
- W2910307871 cites W2010365895 @default.
- W2910307871 cites W2011580879 @default.
- W2910307871 cites W2013935903 @default.
- W2910307871 cites W2017375828 @default.
- W2910307871 cites W2018202134 @default.
- W2910307871 cites W2019154203 @default.
- W2910307871 cites W2019174868 @default.
- W2910307871 cites W2022394206 @default.
- W2910307871 cites W2030353060 @default.
- W2910307871 cites W2033193972 @default.
- W2910307871 cites W2034489750 @default.
- W2910307871 cites W2035208729 @default.
- W2910307871 cites W2036187063 @default.
- W2910307871 cites W2036846467 @default.
- W2910307871 cites W2037296845 @default.
- W2910307871 cites W2037352919 @default.
- W2910307871 cites W2038309664 @default.
- W2910307871 cites W2038599263 @default.
- W2910307871 cites W2048422539 @default.
- W2910307871 cites W2049100937 @default.
- W2910307871 cites W2050897191 @default.
- W2910307871 cites W2051881662 @default.
- W2910307871 cites W2054821149 @default.
- W2910307871 cites W2055830753 @default.
- W2910307871 cites W2061814607 @default.
- W2910307871 cites W2074160345 @default.
- W2910307871 cites W2081164888 @default.
- W2910307871 cites W2083765418 @default.
- W2910307871 cites W2084108448 @default.
- W2910307871 cites W2085186337 @default.
- W2910307871 cites W2086817396 @default.
- W2910307871 cites W2094874423 @default.
- W2910307871 cites W2095472576 @default.
- W2910307871 cites W2099566728 @default.
- W2910307871 cites W2103230563 @default.
- W2910307871 cites W2105350887 @default.
- W2910307871 cites W2106604374 @default.
- W2910307871 cites W2109046615 @default.
- W2910307871 cites W2111884236 @default.
- W2910307871 cites W2113732004 @default.
- W2910307871 cites W2115755902 @default.
- W2910307871 cites W2116475423 @default.
- W2910307871 cites W2119463290 @default.
- W2910307871 cites W2129155846 @default.
- W2910307871 cites W2134286053 @default.
- W2910307871 cites W2139784227 @default.
- W2910307871 cites W2141100160 @default.
- W2910307871 cites W2147245958 @default.
- W2910307871 cites W2147324874 @default.
- W2910307871 cites W2150053757 @default.
- W2910307871 cites W2156717321 @default.
- W2910307871 cites W2157481067 @default.
- W2910307871 cites W2162734332 @default.
- W2910307871 cites W2163041119 @default.
- W2910307871 cites W2163225965 @default.
- W2910307871 cites W2166240292 @default.
- W2910307871 cites W2166557549 @default.
- W2910307871 cites W2167904906 @default.
- W2910307871 cites W2182613283 @default.
- W2910307871 cites W2182962918 @default.
- W2910307871 cites W2198068553 @default.
- W2910307871 cites W2217406169 @default.
- W2910307871 cites W2218066725 @default.