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- W2910310256 endingPage "085" @default.
- W2910310256 startingPage "078" @default.
- W2910310256 abstract "Abstract Identification of sodium taurocholate cotransporting polypeptide (NTCP) as an entry receptor for hepatitis B and D viruses (HBV and HDV) has not only promoted our understanding of the mechanism underlying the viral entry process, but also provided cell culture models supporting viral infection. These models have greatly facilitated cell-based chemical screening for the discovery of entry inhibitors, and mode of action studies using such inhibitors have shown the advantages of NTCP as a drug target. Furthermore, in vitro chemical screening by application of high-throughput affinity-based technologies that target NTCP has identified a variety of unique small molecules that interfere with viral entry. This review summarizes this hot topic in the development of HBV/HDV entry inhibitors, with special focus on the use of NTCP as a drug target." @default.
- W2910310256 created "2019-01-25" @default.
- W2910310256 creator A5024298099 @default.
- W2910310256 creator A5041879220 @default.
- W2910310256 creator A5069473183 @default.
- W2910310256 creator A5081296627 @default.
- W2910310256 date "2019-01-17" @default.
- W2910310256 modified "2023-09-24" @default.
- W2910310256 title "Concept of Viral Inhibitors via NTCP" @default.
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