FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910337821> ?p ?o ?g. }

• W2910337821 endingPage "383" @default.
• W2910337821 startingPage "383" @default.
• W2910337821 abstract "New inhibitors of tubulin polymerization and/or histone deacetylase (HDAC) activity were synthesized by attaching alkyl tethered hydroxamic acid appendages of varying length to oxazole-bridged combretastatin A-4 analogous caps. While their antiproliferative and microtubule disrupting effect was most pronounced for derivatives with short spacers, HDAC inhibition was strongest for those with longer spacers. These findings were further supported by computational methods such as structure-based docking experiments exploring the target interactions of the derivatives with varying linkers. For instance, compounds featuring short four-atom spacers between cap and hydroxamic acid inhibited the growth of various cancer cell lines and human endothelial hybrid cells with IC50 values in the low nanomolar range. In line with their ability to inhibit the microtubule assembly, four- and five-atom spacered hydroxamic acids caused an accumulation of 518A2 melanoma cells in G2/M phase, whereas a compound featuring a six-atom spacer and performing best in HDAC inhibition, induced a G1 arrest in these cells. All these beneficial anticancer activities together with their selectivity for cancer cells over non-malignant cells, point out the great potential of these novel pleiotropic HDAC and tubulin inhibitors as drug candidates for cancer therapy." @default.
• W2910337821 created "2019-01-25" @default.
• W2910337821 creator A5004904788 @default.
• W2910337821 creator A5026002243 @default.
• W2910337821 creator A5039828858 @default.
• W2910337821 creator A5045009637 @default.
• W2910337821 creator A5057416678 @default.
• W2910337821 creator A5062355211 @default.
• W2910337821 creator A5062932587 @default.
• W2910337821 creator A5081096477 @default.
• W2910337821 creator A5085134262 @default.
• W2910337821 date "2019-01-17" @default.
• W2910337821 modified "2023-10-04" @default.
• W2910337821 title "Oxazole-Bridged Combretastatin A-4 Derivatives with Tethered Hydroxamic Acids: Structure–Activity Relations of New Inhibitors of HDAC and/or Tubulin Function" @default.
• W2910337821 cites W1548644314 @default.
• W2910337821 cites W1969323007 @default.
• W2910337821 cites W1970199745 @default.
• W2910337821 cites W1978233546 @default.
• W2910337821 cites W1981569724 @default.
• W2910337821 cites W1982796161 @default.
• W2910337821 cites W1986476355 @default.
• W2910337821 cites W1992735273 @default.
• W2910337821 cites W2001428495 @default.
• W2910337821 cites W2006871036 @default.
• W2910337821 cites W2009805412 @default.
• W2910337821 cites W2015047229 @default.
• W2910337821 cites W2015082085 @default.
• W2910337821 cites W2022478555 @default.
• W2910337821 cites W2022682037 @default.
• W2910337821 cites W2044404885 @default.
• W2910337821 cites W2059024085 @default.
• W2910337821 cites W2061396130 @default.
• W2910337821 cites W2066264051 @default.
• W2910337821 cites W2070200983 @default.
• W2910337821 cites W2071559249 @default.
• W2910337821 cites W2074978479 @default.
• W2910337821 cites W2078211225 @default.
• W2910337821 cites W2083124842 @default.
• W2910337821 cites W2084893501 @default.
• W2910337821 cites W2086384126 @default.
• W2910337821 cites W2087751682 @default.
• W2910337821 cites W2087966689 @default.
• W2910337821 cites W2088418811 @default.
• W2910337821 cites W2090906911 @default.
• W2910337821 cites W2091734240 @default.
• W2910337821 cites W2092476693 @default.
• W2910337821 cites W2105095164 @default.
• W2910337821 cites W2110787699 @default.
• W2910337821 cites W2114918609 @default.
• W2910337821 cites W2130479394 @default.
• W2910337821 cites W2134595846 @default.
• W2910337821 cites W2136406044 @default.
• W2910337821 cites W2142191336 @default.
• W2910337821 cites W2148990197 @default.
• W2910337821 cites W2151492748 @default.
• W2910337821 cites W2159648717 @default.
• W2910337821 cites W2165638033 @default.
• W2910337821 cites W2170154548 @default.
• W2910337821 cites W2220825152 @default.
• W2910337821 cites W2255564941 @default.
• W2910337821 cites W2313004864 @default.
• W2910337821 cites W2318836797 @default.
• W2910337821 cites W2320230258 @default.
• W2910337821 cites W2339601781 @default.
• W2910337821 cites W2499955277 @default.
• W2910337821 cites W2523277769 @default.
• W2910337821 cites W2573197589 @default.
• W2910337821 cites W2685293566 @default.
• W2910337821 cites W2736752247 @default.
• W2910337821 cites W2749849614 @default.
• W2910337821 cites W960967595 @default.
• W2910337821 doi "https://doi.org/10.3390/ijms20020383" @default.
• W2910337821 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6359144" @default.
• W2910337821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30658435" @default.
• W2910337821 hasPublicationYear "2019" @default.
• W2910337821 type Work @default.
• W2910337821 sameAs 2910337821 @default.
• W2910337821 citedByCount "19" @default.
• W2910337821 countsByYear W29103378212019 @default.
• W2910337821 countsByYear W29103378212020 @default.
• W2910337821 countsByYear W29103378212021 @default.
• W2910337821 countsByYear W29103378212022 @default.
• W2910337821 countsByYear W29103378212023 @default.
• W2910337821 crossrefType "journal-article" @default.
• W2910337821 hasAuthorship W2910337821A5004904788 @default.
• W2910337821 hasAuthorship W2910337821A5026002243 @default.
• W2910337821 hasAuthorship W2910337821A5039828858 @default.
• W2910337821 hasAuthorship W2910337821A5045009637 @default.
• W2910337821 hasAuthorship W2910337821A5057416678 @default.
• W2910337821 hasAuthorship W2910337821A5062355211 @default.
• W2910337821 hasAuthorship W2910337821A5062932587 @default.
• W2910337821 hasAuthorship W2910337821A5081096477 @default.
• W2910337821 hasAuthorship W2910337821A5085134262 @default.
• W2910337821 hasBestOaLocation W29103378211 @default.
• W2910337821 hasConcept C104317684 @default.
• W2910337821 hasConcept C121608353 @default.
• W2910337821 hasConcept C159110408 @default.
• W2910337821 hasConcept C168831097 @default.

• next