FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910339979> ?p ?o ?g. }

• W2910339979 endingPage "92" @default.
• W2910339979 startingPage "79" @default.
• W2910339979 abstract "Atherosclerosis in young and premenopausal women with systemic lupus erythematosus (SLE) is frequent, premature and progressive. Although asymptomatic or with atypical clinical presentation, the patients are at high risk of cardiac events. Aim of this study is to estimate the risk profile for atherogenesis and the prevalence of myocardial perfusion abnormalities with 99mTc myocardial perfusion scintigraphy (MPS) in young and premenopausal women.Sixty female patients, aged 30-72 years (divided into two subgroups - patients under 45 years of age and patients over 45 years), diagnosed with SLE for over of 5 years, in active phase of the disease were analyzed for disease activity scores (SLEDAI), the immunologic status of the disease (ANA and a-DNA antibodies in the serum), procoagulant tendency (antiphospholipid antibodies-APhL and lupus-anticoagulant-LAC), the activity of the inflammatory process (hsCRP), the anti-SLE therapeutic approach and the presence of traditional risk factors for atherosclerosis (BMI, smoking, hypertension, hyperlipidemia, diabetes, and familial history for the CAD). Using one-day Dipyridamol - Rest 99mTc SPECT Gated MPS SPECT the extent, severity and reversibility of myocardial perfusion abnormalities were estimated, along with summed scores at stress, rest and summed difference scores and left ventricle volumes and ejection fraction.Abnormal MPS SPECT were detected in 27/60 or in 45% of patients, with one vessel affection of 66.7% (18/27pts) of LAD and 14.8% (4/27pts) o RCA and with two vessel disease of LAD/RCA in 2/27 pts (7.4%) and LAD/Cx in 3/27pts (11.1%). Myocardial perfusion abnormalities were equally prevalent in subgroups of patients younger than 45 years (44,4%) and in patients older than 45 years (45.5%) (ns). The subgroups did not differ significantly concerning the extent of perfusion abnormalities (9,8±3.2% of LV myocardial mass vs. 9,8±7.1%,ns), their severity (with predominance of mild perfusion defects, 48,6% vs. 51,3%,ns) and reversibility (reversible in 41.3% and 58.6%, ns). The differences between the summed scores of severity and the extent of ischemia in the two subgroups were statistically nonsignificant. Younger patients had significantly higher end-diastolic, end-systolic and stroke volumes during stress and rest conditions, compared to older patients (p<0,01) although there were no differences in systolic function, which was not affected in either of the groups as expressed threw ejection fraction. Although nonsignificant, younger patients had higher values of hsCRP and higher procoagulant activity (positive aPhL, LAC) while they were with more active disease activity, with higher SLEDAI score compared to older patients (p=0.028). Higher SLEDAI score and LV volumes, especially EDV at stress were identified as predictor of abnormal MPS in younger groups and more aggressive multidrug anti SLE treatment as predictor of normal MPS.The prevalence and characteristics of myocardial perfusion abnormalities in young SLE are equal as the same in older SLE patients, which indicates the presence of premature, accelerated atherosclerosis in young cohort of patients with SLE. Younger SLE patients with pure disease control (higher SLEDAI score, less aggressive treatment, high hsCRP values and pronounced procoagulant tendency) should undergo screening for myocardial perfusion abnormalities s using 99mTc MIBI MPS)." @default.
• W2910339979 created "2019-01-25" @default.
• W2910339979 creator A5010418901 @default.
• W2910339979 creator A5017909752 @default.
• W2910339979 creator A5018804997 @default.
• W2910339979 creator A5023953721 @default.
• W2910339979 creator A5036009867 @default.
• W2910339979 creator A5037723835 @default.
• W2910339979 creator A5052339172 @default.
• W2910339979 creator A5061191457 @default.
• W2910339979 creator A5062667061 @default.
• W2910339979 creator A5070148536 @default.
• W2910339979 date "2018-12-01" @default.
• W2910339979 modified "2023-10-16" @default.
• W2910339979 title "Myocardial Perfusion Abnormalities in Young and Premenopausal Women with Systemic Lupus Erythematosus, Detected with 99MTC MIBI Myocardial Perfusion Scintigraphy – Prevalence and Correlation with Proatherogenic Factors" @default.
• W2910339979 cites W173062825 @default.
• W2910339979 cites W1972705719 @default.
• W2910339979 cites W1973776684 @default.
• W2910339979 cites W1979095334 @default.
• W2910339979 cites W1988468288 @default.
• W2910339979 cites W2014762747 @default.
• W2910339979 cites W2018760896 @default.
• W2910339979 cites W2021765456 @default.
• W2910339979 cites W2040772268 @default.
• W2910339979 cites W2044410409 @default.
• W2910339979 cites W2045414938 @default.
• W2910339979 cites W2073481329 @default.
• W2910339979 cites W2089151341 @default.
• W2910339979 cites W2115697764 @default.
• W2910339979 cites W2129672202 @default.
• W2910339979 cites W2132658041 @default.
• W2910339979 cites W2141632539 @default.
• W2910339979 cites W2144626611 @default.
• W2910339979 cites W2165779517 @default.
• W2910339979 cites W2325687296 @default.
• W2910339979 cites W2347194024 @default.
• W2910339979 cites W2791310791 @default.
• W2910339979 doi "https://doi.org/10.2478/prilozi-2018-0045" @default.
• W2910339979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30864359" @default.
• W2910339979 hasPublicationYear "2018" @default.
• W2910339979 type Work @default.
• W2910339979 sameAs 2910339979 @default.
• W2910339979 citedByCount "4" @default.
• W2910339979 countsByYear W29103399792019 @default.
• W2910339979 countsByYear W29103399792021 @default.
• W2910339979 countsByYear W29103399792023 @default.
• W2910339979 crossrefType "journal-article" @default.
• W2910339979 hasAuthorship W2910339979A5010418901 @default.
• W2910339979 hasAuthorship W2910339979A5017909752 @default.
• W2910339979 hasAuthorship W2910339979A5018804997 @default.
• W2910339979 hasAuthorship W2910339979A5023953721 @default.
• W2910339979 hasAuthorship W2910339979A5036009867 @default.
• W2910339979 hasAuthorship W2910339979A5037723835 @default.
• W2910339979 hasAuthorship W2910339979A5052339172 @default.
• W2910339979 hasAuthorship W2910339979A5061191457 @default.
• W2910339979 hasAuthorship W2910339979A5062667061 @default.
• W2910339979 hasAuthorship W2910339979A5070148536 @default.
• W2910339979 hasBestOaLocation W29103399791 @default.
• W2910339979 hasConcept C126322002 @default.
• W2910339979 hasConcept C134018914 @default.
• W2910339979 hasConcept C146957229 @default.
• W2910339979 hasConcept C164705383 @default.
• W2910339979 hasConcept C2777910003 @default.
• W2910339979 hasConcept C2778198053 @default.
• W2910339979 hasConcept C2778405248 @default.
• W2910339979 hasConcept C2780022809 @default.
• W2910339979 hasConcept C2780868729 @default.
• W2910339979 hasConcept C555293320 @default.
• W2910339979 hasConcept C71924100 @default.
• W2910339979 hasConcept C78085059 @default.
• W2910339979 hasConceptScore W2910339979C126322002 @default.
• W2910339979 hasConceptScore W2910339979C134018914 @default.
• W2910339979 hasConceptScore W2910339979C146957229 @default.
• W2910339979 hasConceptScore W2910339979C164705383 @default.
• W2910339979 hasConceptScore W2910339979C2777910003 @default.
• W2910339979 hasConceptScore W2910339979C2778198053 @default.
• W2910339979 hasConceptScore W2910339979C2778405248 @default.
• W2910339979 hasConceptScore W2910339979C2780022809 @default.
• W2910339979 hasConceptScore W2910339979C2780868729 @default.
• W2910339979 hasConceptScore W2910339979C555293320 @default.
• W2910339979 hasConceptScore W2910339979C71924100 @default.
• W2910339979 hasConceptScore W2910339979C78085059 @default.
• W2910339979 hasIssue "2-3" @default.
• W2910339979 hasLocation W29103399791 @default.
• W2910339979 hasLocation W29103399792 @default.
• W2910339979 hasOpenAccess W2910339979 @default.
• W2910339979 hasPrimaryLocation W29103399791 @default.
• W2910339979 hasRelatedWork W2028024185 @default.
• W2910339979 hasRelatedWork W2091304161 @default.
• W2910339979 hasRelatedWork W2092154934 @default.
• W2910339979 hasRelatedWork W2157786995 @default.
• W2910339979 hasRelatedWork W2410354677 @default.
• W2910339979 hasRelatedWork W2414539578 @default.
• W2910339979 hasRelatedWork W2424810498 @default.
• W2910339979 hasRelatedWork W3043525524 @default.
• W2910339979 hasRelatedWork W4251565272 @default.
• W2910339979 hasRelatedWork W2086656902 @default.
• W2910339979 hasVolume "39" @default.

• next