Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910343404> ?p ?o ?g. }
- W2910343404 abstract "The effects of cross-link density and composition on the loading and in vitro dissolution of the drug phenytoin as amorphous solid dispersions in emulsion polymerized poly(N-isopropylacrylamide) (PNIPAm) and poly(N-isopropylacrylamide-co-N,N-dimethylacrylamide) nanogels were investigated near the lower critical solution temperature (LCST). Nanogel size and particle density in phosphate buffered saline were quantified by dynamic light scattering (DLS) and viscometry experiments, while drug–nanogel interactions were revealed by cross peaks in aqueous-state nuclear Overhauser effect spectroscopy measurements. Spray-dried dispersions (SDDs) of drug-loaded PNIPAm nanogel particles (R ≈ 43 nm) were directly visualized by cryogenic transmission electron microscopy and further quantified by small-angle X-ray scattering during in vitro dissolution. SDD dissolution profiles were highly dependent on the nanogel cross-link density and directly correlated with the state of dispersion of the drug-loaded nanogel particles. A balance between net particle hydrophobicity and hydrophilicity along with the distance in temperature from the LCST are shown to dictate the in vitro dissolution of the amorphous solid dispersions. Solubility enhancement mechanisms disclosed in this study provide essential guidance for the design of effective nanogels for oral drug delivery applications." @default.
- W2910343404 created "2019-01-25" @default.
- W2910343404 creator A5021121847 @default.
- W2910343404 creator A5043615923 @default.
- W2910343404 creator A5063121259 @default.
- W2910343404 creator A5069824583 @default.
- W2910343404 date "2019-01-16" @default.
- W2910343404 modified "2023-09-27" @default.
- W2910343404 title "Polymer Nanogels as Reservoirs To Inhibit Hydrophobic Drug Crystallization" @default.
- W2910343404 cites W1590254871 @default.
- W2910343404 cites W1772712544 @default.
- W2910343404 cites W1968804888 @default.
- W2910343404 cites W1970767638 @default.
- W2910343404 cites W1973418234 @default.
- W2910343404 cites W1976507470 @default.
- W2910343404 cites W1978300990 @default.
- W2910343404 cites W1979077163 @default.
- W2910343404 cites W1988348032 @default.
- W2910343404 cites W1994726119 @default.
- W2910343404 cites W1996729874 @default.
- W2910343404 cites W2003174286 @default.
- W2910343404 cites W2008380896 @default.
- W2910343404 cites W2008622864 @default.
- W2910343404 cites W2012867962 @default.
- W2910343404 cites W2022830239 @default.
- W2910343404 cites W2023025139 @default.
- W2910343404 cites W2025900229 @default.
- W2910343404 cites W2041517295 @default.
- W2910343404 cites W2050643055 @default.
- W2910343404 cites W2050761628 @default.
- W2910343404 cites W2054963985 @default.
- W2910343404 cites W2056320775 @default.
- W2910343404 cites W2057632167 @default.
- W2910343404 cites W2057716620 @default.
- W2910343404 cites W2058792545 @default.
- W2910343404 cites W2063393943 @default.
- W2910343404 cites W2067192484 @default.
- W2910343404 cites W2067777829 @default.
- W2910343404 cites W2076755375 @default.
- W2910343404 cites W2088408490 @default.
- W2910343404 cites W2091451211 @default.
- W2910343404 cites W2097519121 @default.
- W2910343404 cites W2107488576 @default.
- W2910343404 cites W2112135623 @default.
- W2910343404 cites W2112325559 @default.
- W2910343404 cites W2121175754 @default.
- W2910343404 cites W2121780278 @default.
- W2910343404 cites W2148730186 @default.
- W2910343404 cites W2166209362 @default.
- W2910343404 cites W2256572352 @default.
- W2910343404 cites W2265223650 @default.
- W2910343404 cites W2304404543 @default.
- W2910343404 cites W2322706961 @default.
- W2910343404 cites W2335434301 @default.
- W2910343404 cites W2344598639 @default.
- W2910343404 cites W2530214655 @default.
- W2910343404 cites W2580804305 @default.
- W2910343404 cites W2592857928 @default.
- W2910343404 cites W2606253357 @default.
- W2910343404 cites W2613534422 @default.
- W2910343404 cites W2619953173 @default.
- W2910343404 cites W2782427872 @default.
- W2910343404 cites W2783703994 @default.
- W2910343404 cites W2785664196 @default.
- W2910343404 cites W4211174792 @default.
- W2910343404 doi "https://doi.org/10.1021/acsnano.8b06393" @default.
- W2910343404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30648859" @default.
- W2910343404 hasPublicationYear "2019" @default.
- W2910343404 type Work @default.
- W2910343404 sameAs 2910343404 @default.
- W2910343404 citedByCount "17" @default.
- W2910343404 countsByYear W29103434042019 @default.
- W2910343404 countsByYear W29103434042020 @default.
- W2910343404 countsByYear W29103434042021 @default.
- W2910343404 countsByYear W29103434042022 @default.
- W2910343404 countsByYear W29103434042023 @default.
- W2910343404 crossrefType "journal-article" @default.
- W2910343404 hasAuthorship W2910343404A5021121847 @default.
- W2910343404 hasAuthorship W2910343404A5043615923 @default.
- W2910343404 hasAuthorship W2910343404A5063121259 @default.
- W2910343404 hasAuthorship W2910343404A5069824583 @default.
- W2910343404 hasConcept C127413603 @default.
- W2910343404 hasConcept C13245373 @default.
- W2910343404 hasConcept C134424308 @default.
- W2910343404 hasConcept C14631669 @default.
- W2910343404 hasConcept C155672457 @default.
- W2910343404 hasConcept C15920480 @default.
- W2910343404 hasConcept C159985019 @default.
- W2910343404 hasConcept C171250308 @default.
- W2910343404 hasConcept C187530423 @default.
- W2910343404 hasConcept C188027245 @default.
- W2910343404 hasConcept C188109995 @default.
- W2910343404 hasConcept C192562407 @default.
- W2910343404 hasConcept C2776892847 @default.
- W2910343404 hasConcept C2779820397 @default.
- W2910343404 hasConcept C42360764 @default.
- W2910343404 hasConcept C521977710 @default.
- W2910343404 hasConcept C88380143 @default.
- W2910343404 hasConceptScore W2910343404C127413603 @default.
- W2910343404 hasConceptScore W2910343404C13245373 @default.