FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910346590> ?p ?o ?g. }

• W2910346590 abstract "Degradable phosphate-based glasses have been known to have many potential properties to work as biomaterials for bone repair clinical applications. Although several studies were performed on different compositions to investigate the most appropriate glass formula, no specific formula was found to be the most favourable for clinical application. The main aim of this thesis was to fabricate and biologically assess phosphate glass scaffold made from specific elements known for their potential in promoting bone growth. To achieve this, primary studies were done on four different compositions of both zinc and strontium phosphate-based glass discs. The next study was to further investigate the best two zinc and strontium glass compositions that were obtained from the primary studies using glass beads. As a result of this study, specific composition of both zinc and strontium phosphate glass, having the most favourable cellular response, was recommended to be used for the following experiments. Based on previous compositions, another study was performed to surface functionalise glass discs by coating them with carbon nanotubes (CNTs) and polycaprolactone polymer (PCL) to assess the effect of surface modification on cellular adhesion and metabolic activity. This was subsequently followed by manufacturing, mechanical testing and structural evaluation of zinc and strontium scaffolds. Another experiment was carried out to identify the most suitable technique for scaffold cells seeding by coating scaffolds with fibronectin and collagen. The final study aimed to assess different types of zinc and strontium phosphate glass scaffolds (non-coated, CNT-coated) in both static and dynamic conditions. For the assessment of these scaffolds under dynamic conditions, a perfusion bioreactor was custom made that worked continuously for 28 days. The results revealed that the most preferable glass compositions were identified as ZnO5% and SrO17.5%. Also, glass coating with CNTs and PCL has found to encourage cells adhesion and metabolic activity as it enhanced both surface roughness and hydrophilicity. Scaffold production by sintering technique was thermally optimised and scaffold cellular seeding using collagen coating has yielded the most efficient seeding density. The final results displayed that the most suitable cellular response was found in CNT and PCL coated scaffolds under dynamic conditions (perfusion bioreactors cultivated scaffolds)." @default.
• W2910346590 created "2019-01-25" @default.
• W2910346590 creator A5065312967 @default.
• W2910346590 date "2018-04-28" @default.
• W2910346590 modified "2023-09-28" @default.
• W2910346590 title "Development of Phosphate Based Glass Scaffolds for the Repair of Craniofacial Bone" @default.
• W2910346590 cites W1028342131 @default.
• W2910346590 cites W126207357 @default.
• W2910346590 cites W135251758 @default.
• W2910346590 cites W1481856076 @default.
• W2910346590 cites W1503109784 @default.
• W2910346590 cites W1507716108 @default.
• W2910346590 cites W1518219215 @default.
• W2910346590 cites W1532069065 @default.
• W2910346590 cites W1532656745 @default.
• W2910346590 cites W1533270884 @default.
• W2910346590 cites W1536028936 @default.
• W2910346590 cites W1552151947 @default.
• W2910346590 cites W1559012262 @default.
• W2910346590 cites W1579799438 @default.
• W2910346590 cites W1589737445 @default.
• W2910346590 cites W160114118 @default.
• W2910346590 cites W165592845 @default.
• W2910346590 cites W1757200148 @default.
• W2910346590 cites W1763995212 @default.
• W2910346590 cites W1835257605 @default.
• W2910346590 cites W1853821483 @default.
• W2910346590 cites W1884298585 @default.
• W2910346590 cites W1899123775 @default.
• W2910346590 cites W1913595205 @default.
• W2910346590 cites W1914416900 @default.
• W2910346590 cites W1933549177 @default.
• W2910346590 cites W1958573001 @default.
• W2910346590 cites W1963555074 @default.
• W2910346590 cites W1963743363 @default.
• W2910346590 cites W1964622801 @default.
• W2910346590 cites W1965323992 @default.
• W2910346590 cites W1966118797 @default.
• W2910346590 cites W1966481184 @default.
• W2910346590 cites W1966723290 @default.
• W2910346590 cites W1966750491 @default.
• W2910346590 cites W1967966539 @default.
• W2910346590 cites W1968061504 @default.
• W2910346590 cites W1968509653 @default.
• W2910346590 cites W1969143454 @default.
• W2910346590 cites W1970991061 @default.
• W2910346590 cites W1971339046 @default.
• W2910346590 cites W1971908037 @default.
• W2910346590 cites W1972211130 @default.
• W2910346590 cites W1973826266 @default.
• W2910346590 cites W1974394551 @default.
• W2910346590 cites W1977455246 @default.
• W2910346590 cites W1977770258 @default.
• W2910346590 cites W1977869956 @default.
• W2910346590 cites W1978308958 @default.
• W2910346590 cites W1978416839 @default.
• W2910346590 cites W1979783028 @default.
• W2910346590 cites W1980209512 @default.
• W2910346590 cites W1980292244 @default.
• W2910346590 cites W1980773309 @default.
• W2910346590 cites W1980835835 @default.
• W2910346590 cites W1981296935 @default.
• W2910346590 cites W1981658355 @default.
• W2910346590 cites W1981731794 @default.
• W2910346590 cites W1982888162 @default.
• W2910346590 cites W1983059558 @default.
• W2910346590 cites W1983433452 @default.
• W2910346590 cites W1983685820 @default.
• W2910346590 cites W1984833486 @default.
• W2910346590 cites W1985441897 @default.
• W2910346590 cites W1986102050 @default.
• W2910346590 cites W1986150208 @default.
• W2910346590 cites W1986271597 @default.
• W2910346590 cites W1986659234 @default.
• W2910346590 cites W1986773319 @default.
• W2910346590 cites W1986893291 @default.
• W2910346590 cites W1986999697 @default.
• W2910346590 cites W1987829320 @default.
• W2910346590 cites W1988804877 @default.
• W2910346590 cites W1990387724 @default.
• W2910346590 cites W1991128088 @default.
• W2910346590 cites W1991267506 @default.
• W2910346590 cites W1993399698 @default.
• W2910346590 cites W1994381312 @default.
• W2910346590 cites W1994428003 @default.
• W2910346590 cites W1994465966 @default.
• W2910346590 cites W1995037331 @default.
• W2910346590 cites W1995331939 @default.
• W2910346590 cites W1995723118 @default.
• W2910346590 cites W1995810198 @default.
• W2910346590 cites W1995837084 @default.
• W2910346590 cites W1996552900 @default.
• W2910346590 cites W1996748598 @default.
• W2910346590 cites W1997708993 @default.
• W2910346590 cites W1998727589 @default.
• W2910346590 cites W1999741862 @default.
• W2910346590 cites W1999785568 @default.
• W2910346590 cites W2000503805 @default.
• W2910346590 cites W2001380203 @default.
• W2910346590 cites W2001623103 @default.

• next