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- W2910361081 abstract "The co-infection of the human immunodeficiency virus (HIV) with the viral hepatitis B virus (HBV) is one of the major challenges in the management of HIV. This study aimed to evaluate the prevalence of genotypic mutations of HBV resistance in HBV/HIV co-infected patients and to determine the genetic polymorphism of circulating HBV in a population monitored at CIRBA. The primary objective of this study was to assess the antiviral resistance of HBV and to characterize the genetic variability of HBV in HIV/HBV co-infected patients. This is a cross-sectional descriptive and analytical study conducted from January 2014 to September 2016 at CIRBA. Adult patients co-infected with HBV/HIV on ARV but with detectable HBV viral load were included. HBV resistance genotypes were determined by polymerase (pol) gene sequencing performed on the automatic sequencer (ABI 3130 Avant, Applied Biosystems, Courtaboeuf, France). Of 300 HBV/HIV co-infected patients, thirty-nine (39; 13%) were included. The median viral load was 558 IU/mL. The majority of HBV/HIV co-infected patients (n = 36; 92%) were on triple therapy for HIV-1 infection with two tenofovir + Lamuvidine molecules active on HIV-1 and HBV. Analysis of phylogenetic trees constructed using Mega 7 software confirmed that fifteen (n = 15; 100%) were genotype E strains. Resistance mutations (V173L, L180M, M204V, L180M/L, M204M/V) leading to resistance to Lamuvidine, Telbivudine and Entecavir were observed in five sequenced patients (33.33%). This study confirms the circulation of the HBV genotype E in Cote d'Ivoire with an estimated prevalence of genotypic mutation of 33.3%." @default.
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- W2910361081 date "2018-01-01" @default.
- W2910361081 modified "2023-09-23" @default.
- W2910361081 title "Molecular Characterization and Resistance of Hepatitis B Virus to Polymerase Inhibitors in HIV Co-Infected Patients in Abidjan, Côte d’Ivoire, West Africa" @default.
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