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• W2910361233 abstract "A variety of factors, whether extracellular (mutagens/carcinogens and viruses in the environment, chronic inflammation and radiation associated with the environment and/or electronic devices/machines) and/or intracellular (oxidative metabolites of food, oxidative stress due to inflammation, acid production, replication stress, DNA replication/repair errors, and certain hormones, cytokines, growth factors), pose a constant threat to the genomic integrity of a living cell. However, in the normal cellular environment multiple biological pathways including DNA repair, cell cycle, apoptosis and the immune system work in a precise, regulated (tightly controlled), timely and concerted manner to ensure genomic integrity, stability and proper functioning of a cell. If damage to DNA takes place, it is efficiently and accurately repaired by the DNA repair systems. Homologous recombination (HR) which utilizes either a homologous chromosome (in G1 phase) or a sister chromatid (in G2) as a template to repair the damage, is known to be the most precise repair system. HR in G2 which utilizes a sister chromatid as a template is also called an error free repair system. If DNA damage in a cell is so extensive that it overwhelms the repair system/s, the cell is eliminated by apoptosis. Thus, multiple pathways ensure that genome of a cell is intact and stable. However, constant exposure to DNA damage and/or dysregulation of DNA repair mechanism/s poses a risk of mutation and cancer. Oncogenesis, which seems to be a multistep process, is associated with acquisition of a number of genomic changes that enable a normal cell to progress from benign to malignant transformation. Transformed/cancer cells are recognized and killed by the immune system. However, the ongoing acquisition of new genomic changes enables cancer cells to survive/escape immune attack, evolve into a more aggressive phenotype, and eventually develop resistance to therapy. Although DNA repair (especially the HR) and the immune system play unique roles in preserving genomic integrity of a cell, they can also contribute to DNA damage, genomic instability and oncogenesis. The purpose of this article is to highlight the roles of DNA repair (especially HR) and the immune system in genomic evolution, with special focus on gastrointestinal cancer." @default.
• W2910361233 created "2019-01-25" @default.
• W2910361233 creator A5018998064 @default.
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• W2910361233 creator A5045740077 @default.
• W2910361233 creator A5063099799 @default.
• W2910361233 creator A5079575713 @default.
• W2910361233 date "2018-01-01" @default.
• W2910361233 modified "2023-10-14" @default.
• W2910361233 title "The roles of homologous recombination and the immune system in the genomic evolution of cancer" @default.
• W2910361233 cites W1484972278 @default.
• W2910361233 cites W1592295789 @default.
• W2910361233 cites W1601755300 @default.
• W2910361233 cites W1607316259 @default.
• W2910361233 cites W1784734551 @default.
• W2910361233 cites W1963754762 @default.
• W2910361233 cites W1965037168 @default.
• W2910361233 cites W1966098047 @default.
• W2910361233 cites W1969464492 @default.
• W2910361233 cites W1970227011 @default.
• W2910361233 cites W1975269858 @default.
• W2910361233 cites W1976725183 @default.
• W2910361233 cites W1981426590 @default.
• W2910361233 cites W1996145004 @default.
• W2910361233 cites W2004273407 @default.
• W2910361233 cites W2007325090 @default.
• W2910361233 cites W2014286894 @default.
• W2910361233 cites W2016715613 @default.
• W2910361233 cites W2020184155 @default.
• W2910361233 cites W2021183792 @default.
• W2910361233 cites W2021647091 @default.
• W2910361233 cites W2024459631 @default.
• W2910361233 cites W2024848067 @default.
• W2910361233 cites W2030389529 @default.
• W2910361233 cites W2030797511 @default.
• W2910361233 cites W2032247293 @default.
• W2910361233 cites W2032640722 @default.
• W2910361233 cites W2034092805 @default.
• W2910361233 cites W2034527116 @default.
• W2910361233 cites W2035858672 @default.
• W2910361233 cites W2036785063 @default.
• W2910361233 cites W2040891039 @default.
• W2910361233 cites W2042433863 @default.
• W2910361233 cites W2048888997 @default.
• W2910361233 cites W2051379856 @default.
• W2910361233 cites W2054560592 @default.
• W2910361233 cites W2057461162 @default.
• W2910361233 cites W2067117191 @default.
• W2910361233 cites W2067466498 @default.
• W2910361233 cites W2068290381 @default.
• W2910361233 cites W2070504952 @default.
• W2910361233 cites W2073224213 @default.
• W2910361233 cites W2077436902 @default.
• W2910361233 cites W2077908123 @default.
• W2910361233 cites W2084099620 @default.
• W2910361233 cites W2085192138 @default.
• W2910361233 cites W2093189184 @default.
• W2910361233 cites W2093814864 @default.
• W2910361233 cites W2095617425 @default.
• W2910361233 cites W2109948920 @default.
• W2910361233 cites W2113773748 @default.
• W2910361233 cites W2115852450 @default.
• W2910361233 cites W2116126626 @default.
• W2910361233 cites W2116179256 @default.
• W2910361233 cites W2123105952 @default.
• W2910361233 cites W2127890316 @default.
• W2910361233 cites W2131078803 @default.
• W2910361233 cites W2136223090 @default.
• W2910361233 cites W2138260513 @default.
• W2910361233 cites W2139893790 @default.
• W2910361233 cites W2145200068 @default.
• W2910361233 cites W2152188491 @default.
• W2910361233 cites W2156106286 @default.
• W2910361233 cites W2158542519 @default.
• W2910361233 cites W2159546722 @default.
• W2910361233 cites W2163353298 @default.
• W2910361233 cites W2163671315 @default.
• W2910361233 cites W2176011376 @default.
• W2910361233 cites W2197409178 @default.
• W2910361233 cites W2202899490 @default.
• W2910361233 cites W2240992628 @default.
• W2910361233 cites W2290641535 @default.
• W2910361233 cites W2294927533 @default.
• W2910361233 cites W2327878837 @default.
• W2910361233 cites W2465158514 @default.
• W2910361233 cites W2518520516 @default.
• W2910361233 cites W2562446577 @default.
• W2910361233 cites W2576705148 @default.
• W2910361233 cites W2617691667 @default.
• W2910361233 cites W2766418982 @default.
• W2910361233 cites W2791926234 @default.
• W2910361233 cites W2795227812 @default.
• W2910361233 cites W2801309958 @default.
• W2910361233 cites W2949475756 @default.
• W2910361233 cites W768337726 @default.
• W2910361233 cites W2188365312 @default.
• W2910361233 doi "https://doi.org/10.15761/jts.1000282" @default.

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