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- W2910367567 abstract "The Comparative Toxicogenomics Database (CTD; http://ctdbase.org) is a freely available resource that promotes understanding about the mechanisms by which environmental exposures influence human health. Four categories of content are manually curated from the literature: toxicogenomics (chemical-gene interactions), diseases (chemical-disease and gene-disease associations), phenotypes (chemical-induced phenotypes), and exposure data (environmental stressor-receptor-event-outcome relationships). Exposure details, including stressor source, receptor age, sex, smoking status, biomarker levels, correlations with disease or phenotypes, and geographic location are also recorded. In our curation paradigm, controlled vocabularies, ontologies, mnemonic codes and structured notation are used to transform the literature into a semantic, computable structure, enabling integration among the four categories as well as with gene attributes, molecular pathways, species, and general toxicology information to provide a knowledgebase of over 36 million toxicogenomic relationships. These data can be explored with queries and analytical tools to inform hypothesis development connecting chemicals/drugs, genes/proteins, diseases/phenotypes, taxa, functional annotations, pathways, and population-based exposure events. In addition, they provide unique opportunities to generate predictive adverse outcome pathways (connecting chemical-protein molecular initiating events, key phenotype events, adverse diseases, and population-level health outcomes) as well as aggregate exposure pathways (relating real-world measurements of environmental stressors and biomarkers to demographics). CTD’s centralization of exposure science data, integration with chemical-gene, disease and phenotype modules, and additional analysis tools provide a unique resource to advance our understanding of the molecular mechanisms of action by which environmental exposures affect human health." @default.
- W2910367567 created "2019-01-25" @default.
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- W2910367567 date "2018-09-24" @default.
- W2910367567 modified "2023-09-26" @default.
- W2910367567 title "Using the Comparative Toxicogenomics Database to Further Our Understanding of Environmental Exposures on Human Health" @default.
- W2910367567 doi "https://doi.org/10.1289/isesisee.2018.p03.3420" @default.
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