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• W2910492756 abstract "Abstract We discovered N ‐pyrrolyl alanine derivatives as efficient reagents for the fast and selective Pictet–Spengler reaction with aldehyde‐containing biomolecules. Other aldehyde‐labeling methods described so far have several drawbacks, like hydrolytic instability, slow reaction kinetics or not readily available labeling reagents. Pictet–Spengler cyclizations of pyrrolyl 2‐ethylamine substituted at the pyrrole nitrogen are significantly faster than with analogues substituted at the α‐ and β‐ position. Functionalized N ‐pyrrolyl alanine derivatives can be synthesized in only 2–3 steps from commercially available materials. The small size of the reagent, the high reaction rate, and the easy synthesis make pyrrolyl alanine Pictet–Spengler (PAPS) an attractive choice for bioconjugation reactions. PAPS was shown as an efficient strategy for the site‐selective biotinylation of an antibody as well as for the condensation of nucleic‐acid derivatives, demonstrating the versatility of this reagent." @default.
• W2910492756 created "2019-01-25" @default.
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• W2910492756 date "2019-02-07" @default.
• W2910492756 modified "2023-10-10" @default.
• W2910492756 title "Efficient Pictet-Spengler Bioconjugation with <i>N</i> -Substituted Pyrrolyl Alanine Derivatives" @default.
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• W2910492756 doi "https://doi.org/10.1002/anie.201814200" @default.
• W2910492756 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30653800" @default.
• W2910492756 hasPublicationYear "2019" @default.
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