FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910503960> ?p ?o ?g. }

• W2910503960 endingPage "49" @default.
• W2910503960 startingPage "32" @default.
• W2910503960 abstract "Despite the numerous lives that have been saved since the first successful procedure in 1954, organ transplant has several shortcomings which prevent it from becoming a more comprehensive solution for medical care than it is today. There is a considerable shortage of organ donors, leading to patient death in many cases. In addition, patients require lifelong immunosuppression to prevent graft rejection postoperatively. With such issues in mind, recent research has focused on possible solutions for the lack of access to donor organs and rejections, with the possibility of using the patient’s own cells and tissues for treatment showing enormous potential. Three-dimensional (3D) bioprinting is a rapidly emerging technology, which holds great promise for fabrication of functional tissues and organs. Bioprinting offers the means of utilizing a patient’s cells to design and fabricate constructs for replacement of diseased tissues and organs. It enables the precise positioning of cells and biologics in an automated and high throughput manner. Several studies have shown the promise of 3D bioprinting. However, many problems must be overcome before the generation of functional tissues with biologically-relevant scale is possible. Specific focus on the functionality of bioprinted tissues is required prior to clinical translation. In this perspective, this paper discusses the challenges of functionalization of bioprinted tissue under eight dimensions: biomimicry, cell density, vascularization, innervation, heterogeneity, engraftment, mechanics, and tissue-specific function, and strives to inform the reader with directions in bioprinting complex and volumetric tissues. With thousands of patients dying each year waiting for an organ transplant, bioprinted tissues and organs show the potential to eliminate this ever-increasing organ shortage crisis. However, this potential can only be realized by better understanding the functionality of the organ and developing the ability to translate this to the bioprinting methodologies. Considering the rate at which the field is currently expanding, it is reasonable to expect bioprinting to become an integral component of regenerative medicine. For this purpose, this paper discusses several factors that are critical for printing functional tissues including cell density, vascularization, innervation, heterogeneity, engraftment, mechanics, and tissue-specific function, and inform the reader with future directions in bioprinting complex and volumetric tissues." @default.
• W2910503960 created "2019-01-25" @default.
• W2910503960 creator A5027265520 @default.
• W2910503960 creator A5033158327 @default.
• W2910503960 creator A5035651531 @default.
• W2910503960 creator A5056618662 @default.
• W2910503960 creator A5061360647 @default.
• W2910503960 creator A5072425635 @default.
• W2910503960 creator A5083046197 @default.
• W2910503960 date "2019-09-01" @default.
• W2910503960 modified "2023-10-18" @default.
• W2910503960 title "Bioprinting functional tissues" @default.
• W2910503960 cites W1004941119 @default.
• W2910503960 cites W1858939559 @default.
• W2910503960 cites W1911973481 @default.
• W2910503960 cites W1919370033 @default.
• W2910503960 cites W1942368225 @default.
• W2910503960 cites W1946359510 @default.
• W2910503960 cites W1965511151 @default.
• W2910503960 cites W1966201110 @default.
• W2910503960 cites W1966751409 @default.
• W2910503960 cites W1967696528 @default.
• W2910503960 cites W1969936574 @default.
• W2910503960 cites W1976091266 @default.
• W2910503960 cites W1977564234 @default.
• W2910503960 cites W1979079389 @default.
• W2910503960 cites W1981779415 @default.
• W2910503960 cites W1981998846 @default.
• W2910503960 cites W1988026821 @default.
• W2910503960 cites W1988343344 @default.
• W2910503960 cites W1988887471 @default.
• W2910503960 cites W1990316258 @default.
• W2910503960 cites W1992188676 @default.
• W2910503960 cites W1993727468 @default.
• W2910503960 cites W1994903148 @default.
• W2910503960 cites W2000163264 @default.
• W2910503960 cites W2000587835 @default.
• W2910503960 cites W2000925001 @default.
• W2910503960 cites W2001662737 @default.
• W2910503960 cites W2001925561 @default.
• W2910503960 cites W2001952247 @default.
• W2910503960 cites W2002535120 @default.
• W2910503960 cites W2003576847 @default.
• W2910503960 cites W2005242898 @default.
• W2910503960 cites W2005817636 @default.
• W2910503960 cites W2008276900 @default.
• W2910503960 cites W2009431657 @default.
• W2910503960 cites W2010902667 @default.
• W2910503960 cites W2016058943 @default.
• W2910503960 cites W2017196936 @default.
• W2910503960 cites W2020831247 @default.
• W2910503960 cites W2022697896 @default.
• W2910503960 cites W2024229755 @default.
• W2910503960 cites W2025606893 @default.
• W2910503960 cites W2026220322 @default.
• W2910503960 cites W2028567613 @default.
• W2910503960 cites W2034722366 @default.
• W2910503960 cites W2035539888 @default.
• W2910503960 cites W2036437770 @default.
• W2910503960 cites W2038202065 @default.
• W2910503960 cites W2039710683 @default.
• W2910503960 cites W2040984241 @default.
• W2910503960 cites W2041307278 @default.
• W2910503960 cites W2043704558 @default.
• W2910503960 cites W2044855501 @default.
• W2910503960 cites W2047492111 @default.
• W2910503960 cites W2048498434 @default.
• W2910503960 cites W2048644480 @default.
• W2910503960 cites W2061223357 @default.
• W2910503960 cites W2064299621 @default.
• W2910503960 cites W2066612010 @default.
• W2910503960 cites W2067667764 @default.
• W2910503960 cites W2073302050 @default.
• W2910503960 cites W2080500213 @default.
• W2910503960 cites W2082711170 @default.
• W2910503960 cites W2083994991 @default.
• W2910503960 cites W2092760711 @default.
• W2910503960 cites W2094791883 @default.
• W2910503960 cites W2094800427 @default.
• W2910503960 cites W2095944209 @default.
• W2910503960 cites W2097154761 @default.
• W2910503960 cites W2098594636 @default.
• W2910503960 cites W2103589970 @default.
• W2910503960 cites W2105559315 @default.
• W2910503960 cites W2105685140 @default.
• W2910503960 cites W2107474816 @default.
• W2910503960 cites W2110507992 @default.
• W2910503960 cites W2111802374 @default.
• W2910503960 cites W2112282929 @default.
• W2910503960 cites W2115609745 @default.
• W2910503960 cites W2115728174 @default.
• W2910503960 cites W2116948130 @default.
• W2910503960 cites W2129322399 @default.
• W2910503960 cites W2130475692 @default.
• W2910503960 cites W2133683725 @default.
• W2910503960 cites W2134208433 @default.
• W2910503960 cites W2140202284 @default.
• W2910503960 cites W2140503411 @default.

• next