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- W2910513585 abstract "Background Mast cells (MCs) are immune cells implicated in the pathogenesis of Rheumatoid Arthritis (RA), but their presence in synovia has not been assessed systematically and their association with disease progression and treatment response is unknown. Objectives To analyse MCs in the synovia of patients with early vs established RA in correlation with histological and clinical phenotype. Methods DMARDs-naive patients with early ( Results In the cohort of DMARDs-naive early RA (mean disease duration 6 months), MC+ve patients (67.7%) had significantly higher synovial inflammation (Krenn score), higher prevalence of the lymphoid pathotype, higher inflammatory markers and disease activity; however, they did not differ in terms of response to sDMARDs at 6 months (table 1, left). In established RA (mean disease duration 5 years), MC+ve patients (48.1%) had significantly higher synovial inflammatory scores and higher prevalence of the lymphoid pathotype, while systemic inflammatory markers or disease activity scores were not different. At 6 months follow-up, MC+ve patients had significantly higher rates of response to anti-TNFα (table 2, right). Conclusions We here show that early RA patients with MC+ve synovitis and high levels of local and systemic inflammation do not respond differently to synthetic DMARDs. In the context of established RA after sDMARDs failure, patients with MC+ve synovitis, despite having similar levels of systemic inflammatory markers and disease activity, had higher chances of responding to anti-TNF-α. Although the latter observation will need validation on larger cohorts, our data suggests that the analysis of synovial MCs might help defining synovial histopathology and possibly contribute to the prediction of treatment response. Reference [1] Mast cells in rheumatoid arthritis: friends or foes? Rivellese F, Nerviani A, Rossi FW, Marone G, Matucci-Cerinic M, de Paulis A, Pitzalis C. Autoimmun Rev2017Jun;16(6):557–563. doi:10.1016/j.autrev.2017.04.001 Disclosure of Interest None declared" @default.
- W2910513585 created "2019-01-25" @default.
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- W2910513585 date "2018-06-01" @default.
- W2910513585 modified "2023-09-24" @default.
- W2910513585 title "SAT0076 Synovial mast cells and responses to synthetic and biologic dmards in early and established rheumatoid arthritis" @default.
- W2910513585 doi "https://doi.org/10.1136/annrheumdis-2018-eular.6839" @default.
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