FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910533485> ?p ?o ?g. }

• W2910533485 endingPage "1364" @default.
• W2910533485 startingPage "1355" @default.
• W2910533485 abstract "In myelodysplastic syndromes with a partial deletion of the long arm of chromosome 5, del(5q), lenalidomide is believed to reverse anergic T-cell immunity in the bone marrow resulting in suppression of the del(5q) clone. In this study we used next-generation sequencing of immunoglobulin heavy chain (IGH) and T-cell receptor beta (TRB) rearrangements in bone marrow-residing and peripheral blood-circulating lymphocytes of patients with del(5q) myelodysplastic syndromes to assess the immune architecture and track adaptive immune responses during treatment with lenalidomide. The baseline bone marrow B-cell space in patients was comparable to that of age-matched healthy controls in terms of gene usage and IGH clonality, but showed a higher percentage of hypermutated IGH sequences, indicating an expanded number of antigen-experienced B lineage cells. Bone marrow B lineage clonality decreased significantly and hypermutated IGH clones normalized upon lenalidomide treatment, well in line with the proliferative effect on healthy antigen-inexperienced B-cell precursors previously described for this drug. The T-cell space in bone marrow of patients with del(5q) myelodysplastic syndromes showed higher TRB clonality compared to that of healthy controls. Upon lenalidomide treatment, myelodysplastic syndrome-specific T-cell clusters with low to medium spontaneous generation probabilities emerged; these clusters were shared across patients, indicating a common antigen-driven T-cell response pattern. Hence, we observed B lineage diversification and generation of new, antigen-dependent T-cell clusters, compatible with a model of adaptive immunity induced against the del(5q) clone by lenalidomide. Overall, this supports the concept that lenalidomide not only alters the functional T-cell state, but also the composition of the T- and B-cell repertoires in del(5q) myelodysplastic syndromes." @default.
• W2910533485 created "2019-01-25" @default.
• W2910533485 creator A5025009733 @default.
• W2910533485 creator A5029332875 @default.
• W2910533485 creator A5031365936 @default.
• W2910533485 creator A5033107517 @default.
• W2910533485 creator A5045595168 @default.
• W2910533485 creator A5055601574 @default.
• W2910533485 creator A5056927851 @default.
• W2910533485 creator A5063615217 @default.
• W2910533485 creator A5064653644 @default.
• W2910533485 creator A5074393737 @default.
• W2910533485 creator A5077205301 @default.
• W2910533485 creator A5088324204 @default.
• W2910533485 date "2019-01-17" @default.
• W2910533485 modified "2023-10-14" @default.
• W2910533485 title "Deep sequencing of bone marrow microenvironments of patients with del(5q) myelodysplastic syndrome reveals imprints of antigenic selection as well as generation of novel T-cell clusters as a response pattern to lenalidomide" @default.
• W2910533485 cites W1527383154 @default.
• W2910533485 cites W1574516418 @default.
• W2910533485 cites W1631719479 @default.
• W2910533485 cites W1966738144 @default.
• W2910533485 cites W1973532909 @default.
• W2910533485 cites W1982589355 @default.
• W2910533485 cites W1991753383 @default.
• W2910533485 cites W1992370821 @default.
• W2910533485 cites W1998927848 @default.
• W2910533485 cites W1999169128 @default.
• W2910533485 cites W2015345028 @default.
• W2910533485 cites W2020094108 @default.
• W2910533485 cites W2039123767 @default.
• W2910533485 cites W2052041910 @default.
• W2910533485 cites W2059009461 @default.
• W2910533485 cites W2066053804 @default.
• W2910533485 cites W2089041106 @default.
• W2910533485 cites W2090011679 @default.
• W2910533485 cites W2093845572 @default.
• W2910533485 cites W2102862705 @default.
• W2910533485 cites W2119704331 @default.
• W2910533485 cites W2121533623 @default.
• W2910533485 cites W2133832061 @default.
• W2910533485 cites W2140256561 @default.
• W2910533485 cites W2163764082 @default.
• W2910533485 cites W2211315362 @default.
• W2910533485 cites W2282550179 @default.
• W2910533485 cites W2343599588 @default.
• W2910533485 cites W2400090719 @default.
• W2910533485 cites W2434407168 @default.
• W2910533485 cites W2560830801 @default.
• W2910533485 cites W2670890989 @default.
• W2910533485 cites W2733520933 @default.
• W2910533485 cites W2739940690 @default.
• W2910533485 cites W2761324187 @default.
• W2910533485 cites W2761575992 @default.
• W2910533485 cites W2778020060 @default.
• W2910533485 cites W3102596196 @default.
• W2910533485 doi "https://doi.org/10.3324/haematol.2018.208223" @default.
• W2910533485 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6601099" @default.
• W2910533485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30655375" @default.
• W2910533485 hasPublicationYear "2019" @default.
• W2910533485 type Work @default.
• W2910533485 sameAs 2910533485 @default.
• W2910533485 citedByCount "6" @default.
• W2910533485 countsByYear W29105334852019 @default.
• W2910533485 countsByYear W29105334852021 @default.
• W2910533485 countsByYear W29105334852023 @default.
• W2910533485 crossrefType "journal-article" @default.
• W2910533485 hasAuthorship W2910533485A5025009733 @default.
• W2910533485 hasAuthorship W2910533485A5029332875 @default.
• W2910533485 hasAuthorship W2910533485A5031365936 @default.
• W2910533485 hasAuthorship W2910533485A5033107517 @default.
• W2910533485 hasAuthorship W2910533485A5045595168 @default.
• W2910533485 hasAuthorship W2910533485A5055601574 @default.
• W2910533485 hasAuthorship W2910533485A5056927851 @default.
• W2910533485 hasAuthorship W2910533485A5063615217 @default.
• W2910533485 hasAuthorship W2910533485A5064653644 @default.
• W2910533485 hasAuthorship W2910533485A5074393737 @default.
• W2910533485 hasAuthorship W2910533485A5077205301 @default.
• W2910533485 hasAuthorship W2910533485A5088324204 @default.
• W2910533485 hasBestOaLocation W29105334851 @default.
• W2910533485 hasConcept C104317684 @default.
• W2910533485 hasConcept C113968399 @default.
• W2910533485 hasConcept C147483822 @default.
• W2910533485 hasConcept C203014093 @default.
• W2910533485 hasConcept C2776063141 @default.
• W2910533485 hasConcept C2776364478 @default.
• W2910533485 hasConcept C2780007613 @default.
• W2910533485 hasConcept C2780817109 @default.
• W2910533485 hasConcept C502942594 @default.
• W2910533485 hasConcept C54355233 @default.
• W2910533485 hasConcept C81089528 @default.
• W2910533485 hasConcept C86803240 @default.
• W2910533485 hasConcept C8891405 @default.
• W2910533485 hasConceptScore W2910533485C104317684 @default.
• W2910533485 hasConceptScore W2910533485C113968399 @default.
• W2910533485 hasConceptScore W2910533485C147483822 @default.
• W2910533485 hasConceptScore W2910533485C203014093 @default.
• W2910533485 hasConceptScore W2910533485C2776063141 @default.
• W2910533485 hasConceptScore W2910533485C2776364478 @default.

• next