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- W2910551467 abstract "Abstract Herpes zoster (HZ) incidence increases with age, especially after the age of 50 years, due to declining varicella-zoster virus (VZV)–specific cell-mediated immunity. Vaccines designed to boost VZV-specific immunity are effective in preventing HZ. A single-dose ”live attenuated zoster vaccine” (ZVL) reduces HZ risk by 51% in people aged ≥60 years over a median of 3.1 years. A two-dose adjuvanted subunit vaccine (HZ/su) containing a single VZV glyco-protein reduces the risk of HZ by >90% in adults aged 50 years or above. Vaccine efficacy decreases with advancing age for the ZVL but not for HZ/su, which is advantageous for aging populations." @default.
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- W2910551467 date "2019-01-01" @default.
- W2910551467 modified "2023-09-26" @default.
- W2910551467 title "Herpes Zoster Vaccines" @default.
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- W2910551467 doi "https://doi.org/10.1016/b978-0-323-55435-0.00004-5" @default.
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