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- W2910584283 abstract "Persisters are transiently antibiotic-tolerant cells that complicate the treatment of bacterial infections. Both theory and experiments have suggested that persisters facilitate genetic resistance by constituting an evolutionary reservoir of viable cells. Here, we provide evidence for a strong positive correlation between persistence and the likelihood to become genetically resistant in natural and lab strains of E. coli. This correlation can be partly attributed to the increased availability of viable cells associated with persistence. However, our data additionally show that persistence is pleiotropically linked with mutation rates. Our theoretical model further demonstrates that increased survival and mutation rates jointly affect the likelihood of evolving clinical resistance. Overall, these results suggest that the battle against antibiotic resistance will benefit from incorporating anti-persister therapies." @default.
- W2910584283 created "2019-01-25" @default.
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- W2910584283 creator A5063661741 @default.
- W2910584283 creator A5070523413 @default.
- W2910584283 date "2019-01-15" @default.
- W2910584283 modified "2023-10-16" @default.
- W2910584283 title "Bacterial persistence promotes the evolution of antibiotic resistance by increasing survival and mutation rates" @default.
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- W2910584283 cites W1907149689 @default.
- W2910584283 cites W1969307309 @default.
- W2910584283 cites W1974078111 @default.
- W2910584283 cites W1977064553 @default.
- W2910584283 cites W1979767547 @default.
- W2910584283 cites W1980357487 @default.
- W2910584283 cites W1983042430 @default.
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- W2910584283 cites W2030847176 @default.
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- W2910584283 cites W2586590237 @default.
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- W2910584283 doi "https://doi.org/10.1038/s41396-019-0344-9" @default.
- W2910584283 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6474225" @default.
- W2910584283 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30647458" @default.
- W2910584283 hasPublicationYear "2019" @default.
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