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- W2910585959 abstract "Abstract Coxsackievirus A10 (CV-A10) belongs to the Enterovirus species A and is a causative agent of hand, foot, and mouth disease. Here we present cryo-EM structures of CV-A10 mature virion and native empty particle (NEP) at 2.84 and 3.12 Å, respectively. Our CV-A10 mature virion structure reveals a density corresponding to a lipidic pocket factor of 18 carbon atoms in the hydrophobic pocket formed within viral protein 1. By structure-guided high-throughput drug screening and subsequent verification in cell-based infection-inhibition assays, we identified four compounds that inhibited CV-A10 infection in vitro. These compounds represent a new class of anti-enteroviral drug leads. Notably, one of the compounds, ICA135, also exerted broad-spectrum inhibitory effects on a number of representative viruses from all four species (A–D) of human enteroviruses. Our findings should facilitate the development of broadly effective drugs and vaccines for enterovirus infections." @default.
- W2910585959 created "2019-01-25" @default.
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- W2910585959 date "2019-01-15" @default.
- W2910585959 modified "2023-10-12" @default.
- W2910585959 title "Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses" @default.
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- W2910585959 doi "https://doi.org/10.1038/s41421-018-0073-7" @default.
- W2910585959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6331555" @default.
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- W2910585959 hasPublicationYear "2019" @default.
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