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- W2910594585 abstract "Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder in the world, and intracellular neurofibrillary tangles and extracellular amyloid-beta protein deposits represent the major pathological hallmarks of the disease. Currently available treatments provide some symptomatic relief but fail to modify primary pathological processes that underlie the disease. Erythropoietin (EPO), a hematopoietic growth factor, acts primarily to stimulate erythroid cell production, and is clinically used to treat anemia. EPO has evolved as a therapeutic agent for neurodegeneration and has improved neurological outcomes and AD pathology in rodents. However, penetration of the blood–brain barrier (BBB) and negative hematopoietic effects are the two major challenges for the therapeutic development of EPO for chronic neurodegenerative diseases like AD. The transferrin receptors at the BBB, which are responsible for transporting transferrin-bound iron from the blood into the brain parenchyma, can be used to shuttle therapeutic molecules across the BBB. In this review, we discuss the role of EPO as a potential neurotherapeutic for AD, challenges associated with EPO development for AD, and targeting the BBB transferrin receptor for EPO brain delivery." @default.
- W2910594585 created "2019-01-25" @default.
- W2910594585 creator A5012713059 @default.
- W2910594585 creator A5058573585 @default.
- W2910594585 creator A5066252030 @default.
- W2910594585 creator A5083245275 @default.
- W2910594585 date "2019-01-17" @default.
- W2910594585 modified "2023-10-17" @default.
- W2910594585 title "The Promises and Challenges of Erythropoietin for Treatment of Alzheimer’s Disease" @default.
- W2910594585 cites W124108543 @default.
- W2910594585 cites W1481345637 @default.
- W2910594585 cites W1504954730 @default.
- W2910594585 cites W1509766815 @default.
- W2910594585 cites W1572873489 @default.
- W2910594585 cites W1585782290 @default.
- W2910594585 cites W1592192663 @default.
- W2910594585 cites W1594404253 @default.
- W2910594585 cites W1596429639 @default.
- W2910594585 cites W1670034715 @default.
- W2910594585 cites W1726817518 @default.
- W2910594585 cites W1805975457 @default.
- W2910594585 cites W1820933137 @default.
- W2910594585 cites W1846263906 @default.
- W2910594585 cites W1868333091 @default.
- W2910594585 cites W1927567505 @default.
- W2910594585 cites W1964585341 @default.
- W2910594585 cites W1964718511 @default.
- W2910594585 cites W1967541880 @default.
- W2910594585 cites W1967823816 @default.
- W2910594585 cites W1972326404 @default.
- W2910594585 cites W1972812487 @default.
- W2910594585 cites W1973026127 @default.
- W2910594585 cites W1973130935 @default.
- W2910594585 cites W1973178224 @default.
- W2910594585 cites W1976602187 @default.
- W2910594585 cites W1976869427 @default.
- W2910594585 cites W1978726693 @default.
- W2910594585 cites W1980085014 @default.
- W2910594585 cites W1980940682 @default.
- W2910594585 cites W1986436077 @default.
- W2910594585 cites W1987814370 @default.
- W2910594585 cites W1992652994 @default.
- W2910594585 cites W1993788242 @default.
- W2910594585 cites W1994067502 @default.
- W2910594585 cites W1995413041 @default.
- W2910594585 cites W1996719014 @default.
- W2910594585 cites W1999794509 @default.
- W2910594585 cites W2000917982 @default.
- W2910594585 cites W2003306914 @default.
- W2910594585 cites W2005218288 @default.
- W2910594585 cites W2006717582 @default.
- W2910594585 cites W2011552741 @default.
- W2910594585 cites W2014141048 @default.
- W2910594585 cites W2023648524 @default.
- W2910594585 cites W2025061302 @default.
- W2910594585 cites W2025164402 @default.
- W2910594585 cites W2025919785 @default.
- W2910594585 cites W2026077861 @default.
- W2910594585 cites W2027978484 @default.
- W2910594585 cites W2029705843 @default.
- W2910594585 cites W2037902576 @default.
- W2910594585 cites W2041098348 @default.
- W2910594585 cites W2042883199 @default.
- W2910594585 cites W2044682044 @default.
- W2910594585 cites W2045153164 @default.
- W2910594585 cites W2048998483 @default.
- W2910594585 cites W2052766986 @default.
- W2910594585 cites W2059483016 @default.
- W2910594585 cites W2059975827 @default.
- W2910594585 cites W2061883196 @default.
- W2910594585 cites W2064145055 @default.
- W2910594585 cites W2066116456 @default.
- W2910594585 cites W2066912376 @default.
- W2910594585 cites W2072102778 @default.
- W2910594585 cites W2072650744 @default.
- W2910594585 cites W2082429191 @default.
- W2910594585 cites W2087243986 @default.
- W2910594585 cites W2088034288 @default.
- W2910594585 cites W2091746744 @default.
- W2910594585 cites W2092356280 @default.
- W2910594585 cites W2092523325 @default.
- W2910594585 cites W2093650784 @default.
- W2910594585 cites W2095473686 @default.
- W2910594585 cites W2100276489 @default.
- W2910594585 cites W2101099825 @default.
- W2910594585 cites W2103255946 @default.
- W2910594585 cites W2103440561 @default.
- W2910594585 cites W2104704429 @default.
- W2910594585 cites W2106855201 @default.
- W2910594585 cites W2107294231 @default.
- W2910594585 cites W2108089603 @default.
- W2910594585 cites W2109613116 @default.
- W2910594585 cites W2109699895 @default.
- W2910594585 cites W2110569992 @default.
- W2910594585 cites W2111348099 @default.
- W2910594585 cites W2112499304 @default.
- W2910594585 cites W2114690241 @default.
- W2910594585 cites W2114694618 @default.