FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910599879> ?p ?o ?g. }

• W2910599879 endingPage "183" @default.
• W2910599879 startingPage "169" @default.
• W2910599879 abstract "Motor neuron damage caused by diseases, traumatic insults or de-afferentation of the spinal cord is often incurable due to the poor intrinsic regenerative capacity. Moreover, regenerated peripheral nerves often do not reach normal functionality. Here, we investigated cardiolipin in the process of neuro-differentiation, since cardiolipin is closely linked to the mitochondrial energy supply in cells. The NSC-34 hybrid cell line, produced by fusing neuroblastoma cells with primary spinal cord motor neurons, was used, since it shares several morphological and physiological characteristics with mature primary motor neurons. Their neuro-differentiation was supported by switching from normal to differentiation medium or by fatty acid supplementation. Differentiation was evaluated by measuring neurite-sprouting parameters and PPARα expression. Cellular fatty acid distribution was analyzed to indicate changes in lipid metabolism during differentiation. Cardiolipin was characterized by acyl-chain composition and the distribution of molecular cardiolipin species. Both, the switch from normal to differentiation medium as well as the administration of palmitic and oleic acid promoted neuro-differentiation. Stimulated differentiation was accompanied by changes in cardiolipin content and composition. The positive correlation between neuro-differentiation and concentration of those molecular cardiolipin species containing palmitic and oleic acid implied a link between differentiation of NSC-34 cells and cardiolipin metabolism. We further demonstrated the impact of cellular lipid metabolism, and particularly cardiolipin metabolism, during and NSC-34 neuritogenesis. Thus, cardiolipin may represent a new therapeutic target for axon regeneration after peripheral nerve injuries or when axon sprouting is required to compensate for motor neuron loss in response to aging and/or disease." @default.
• W2910599879 created "2019-01-25" @default.
• W2910599879 creator A5033666485 @default.
• W2910599879 creator A5065080624 @default.
• W2910599879 creator A5075202378 @default.
• W2910599879 creator A5082052984 @default.
• W2910599879 date "2019-02-01" @default.
• W2910599879 modified "2023-10-03" @default.
• W2910599879 title "The Differentiation of Spinal Cord Motor Neurons is Associated with Changes of the Mitochondrial Phospholipid Cardiolipin" @default.
• W2910599879 cites W1544933179 @default.
• W2910599879 cites W1690638120 @default.
• W2910599879 cites W1853579944 @default.
• W2910599879 cites W1944646169 @default.
• W2910599879 cites W1967824509 @default.
• W2910599879 cites W1969770915 @default.
• W2910599879 cites W1972032978 @default.
• W2910599879 cites W1974114814 @default.
• W2910599879 cites W1975998750 @default.
• W2910599879 cites W1977795850 @default.
• W2910599879 cites W1983338135 @default.
• W2910599879 cites W1983617509 @default.
• W2910599879 cites W1984710762 @default.
• W2910599879 cites W2000562839 @default.
• W2910599879 cites W2000853431 @default.
• W2910599879 cites W2000980312 @default.
• W2910599879 cites W2004693594 @default.
• W2910599879 cites W2008539746 @default.
• W2910599879 cites W2010233410 @default.
• W2910599879 cites W2015312498 @default.
• W2910599879 cites W2019264715 @default.
• W2910599879 cites W2022870540 @default.
• W2910599879 cites W2026879435 @default.
• W2910599879 cites W2031687154 @default.
• W2910599879 cites W2039136509 @default.
• W2910599879 cites W2047540235 @default.
• W2910599879 cites W2047680845 @default.
• W2910599879 cites W2048247819 @default.
• W2910599879 cites W2051393353 @default.
• W2910599879 cites W2062905130 @default.
• W2910599879 cites W2069709760 @default.
• W2910599879 cites W2074669091 @default.
• W2910599879 cites W2080415175 @default.
• W2910599879 cites W2083822522 @default.
• W2910599879 cites W2101432424 @default.
• W2910599879 cites W2105793408 @default.
• W2910599879 cites W2120469313 @default.
• W2910599879 cites W2122339118 @default.
• W2910599879 cites W2127207912 @default.
• W2910599879 cites W2129924014 @default.
• W2910599879 cites W2135702611 @default.
• W2910599879 cites W2137400870 @default.
• W2910599879 cites W2139076333 @default.
• W2910599879 cites W2143172845 @default.
• W2910599879 cites W2146283444 @default.
• W2910599879 cites W2150565429 @default.
• W2910599879 cites W2154722036 @default.
• W2910599879 cites W2166742653 @default.
• W2910599879 cites W2167763455 @default.
• W2910599879 cites W2169957088 @default.
• W2910599879 cites W2260947841 @default.
• W2910599879 cites W2300498632 @default.
• W2910599879 cites W2395233680 @default.
• W2910599879 cites W2410831727 @default.
• W2910599879 cites W2416232269 @default.
• W2910599879 cites W2509432673 @default.
• W2910599879 cites W2509802254 @default.
• W2910599879 cites W2553450649 @default.
• W2910599879 cites W2561130149 @default.
• W2910599879 cites W2564799615 @default.
• W2910599879 cites W2585451921 @default.
• W2910599879 cites W2589816720 @default.
• W2910599879 cites W2590259245 @default.
• W2910599879 cites W2601743360 @default.
• W2910599879 cites W2615489098 @default.
• W2910599879 cites W2625336870 @default.
• W2910599879 cites W2751849010 @default.
• W2910599879 cites W2757651286 @default.
• W2910599879 doi "https://doi.org/10.1016/j.neuroscience.2019.01.005" @default.
• W2910599879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30639394" @default.
• W2910599879 hasPublicationYear "2019" @default.
• W2910599879 type Work @default.
• W2910599879 sameAs 2910599879 @default.
• W2910599879 citedByCount "7" @default.
• W2910599879 countsByYear W29105998792019 @default.
• W2910599879 countsByYear W29105998792020 @default.
• W2910599879 countsByYear W29105998792021 @default.
• W2910599879 countsByYear W29105998792023 @default.
• W2910599879 crossrefType "journal-article" @default.
• W2910599879 hasAuthorship W2910599879A5033666485 @default.
• W2910599879 hasAuthorship W2910599879A5065080624 @default.
• W2910599879 hasAuthorship W2910599879A5075202378 @default.
• W2910599879 hasAuthorship W2910599879A5082052984 @default.
• W2910599879 hasConcept C104317684 @default.
• W2910599879 hasConcept C113246987 @default.
• W2910599879 hasConcept C148738053 @default.
• W2910599879 hasConcept C169760540 @default.
• W2910599879 hasConcept C185592680 @default.
• W2910599879 hasConcept C202751555 @default.

• next