Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910608506> ?p ?o ?g. }
- W2910608506 abstract "Abstract The emergence of eukaryotes from ancient prokaryotic lineages was accompanied by a remarkable increase in cellular complexity. While prokaryotes use simple systems to connect DNA to the segregation machinery during cell division, eukaryotes use a highly complex protein assembly known as the kinetochore. Although conceptually similar, prokaryotic segregation systems and eukaryotic kinetochore proteins share no homology, raising the question of the origins of the latter. Using large-scale gene family reconstruction, sensitive profile-versus-profile homology detection and protein structural comparisons, we here reveal that the kinetochore of the last eukaryotic common ancestor (LECA) consisted of 52 proteins that share deep evolutionary histories with proteins involved in a few prokaryotic processes and a multitude of eukaryotic processes, including ubiquitination, chromatin regulation and flagellar as well as vesicular transport systems. We find that gene duplications played a major role in shaping the kinetochore: roughly half of LECA kinetochore proteins have other kinetochore proteins as closest homologs. Some of these (e.g. subunits of the Mis12 complex) have no detectable homology to any other eukaryotic protein, suggesting they arose as kinetochore-specific proteins de novo before LECA. We propose that the primordial kinetochore evolved from proteins involved in various (pre-)eukaryotic systems as well as novel proteins, after which a subset duplicated to give rise to the complex kinetochore of LECA." @default.
- W2910608506 created "2019-01-25" @default.
- W2910608506 creator A5045168589 @default.
- W2910608506 creator A5056545178 @default.
- W2910608506 creator A5057662792 @default.
- W2910608506 creator A5073334415 @default.
- W2910608506 date "2019-01-08" @default.
- W2910608506 modified "2023-10-18" @default.
- W2910608506 title "Mosaic origin of the eukaryotic kinetochore" @default.
- W2910608506 cites W1480389476 @default.
- W2910608506 cites W1904473365 @default.
- W2910608506 cites W1939911045 @default.
- W2910608506 cites W1963842907 @default.
- W2910608506 cites W1966350453 @default.
- W2910608506 cites W1976577540 @default.
- W2910608506 cites W1983529968 @default.
- W2910608506 cites W1983642572 @default.
- W2910608506 cites W1984013070 @default.
- W2910608506 cites W1984128119 @default.
- W2910608506 cites W1991118423 @default.
- W2910608506 cites W2036502020 @default.
- W2910608506 cites W2040065157 @default.
- W2910608506 cites W2048935540 @default.
- W2910608506 cites W2051419563 @default.
- W2910608506 cites W2053008886 @default.
- W2910608506 cites W2059803549 @default.
- W2910608506 cites W2072089764 @default.
- W2910608506 cites W2082188981 @default.
- W2910608506 cites W2091677101 @default.
- W2910608506 cites W2097795961 @default.
- W2910608506 cites W2101425827 @default.
- W2910608506 cites W2111810443 @default.
- W2910608506 cites W2119122283 @default.
- W2910608506 cites W2122235477 @default.
- W2910608506 cites W2126302545 @default.
- W2910608506 cites W2137811518 @default.
- W2910608506 cites W2140381945 @default.
- W2910608506 cites W2144889160 @default.
- W2910608506 cites W2146677747 @default.
- W2910608506 cites W2151759271 @default.
- W2910608506 cites W2152896440 @default.
- W2910608506 cites W2167082435 @default.
- W2910608506 cites W2167602881 @default.
- W2910608506 cites W2168281981 @default.
- W2910608506 cites W2170394655 @default.
- W2910608506 cites W2172137589 @default.
- W2910608506 cites W2178130253 @default.
- W2910608506 cites W2301533823 @default.
- W2910608506 cites W2319996093 @default.
- W2910608506 cites W2395192471 @default.
- W2910608506 cites W2469423826 @default.
- W2910608506 cites W2495169411 @default.
- W2910608506 cites W2525071421 @default.
- W2910608506 cites W2544693274 @default.
- W2910608506 cites W2578958622 @default.
- W2910608506 cites W2586691160 @default.
- W2910608506 cites W2620130100 @default.
- W2910608506 cites W2683561870 @default.
- W2910608506 cites W2743709860 @default.
- W2910608506 cites W2768268787 @default.
- W2910608506 cites W2771607216 @default.
- W2910608506 cites W2776561065 @default.
- W2910608506 cites W2778507724 @default.
- W2910608506 cites W2808808201 @default.
- W2910608506 cites W2886591234 @default.
- W2910608506 cites W4214677910 @default.
- W2910608506 doi "https://doi.org/10.1101/514885" @default.
- W2910608506 hasPublicationYear "2019" @default.
- W2910608506 type Work @default.
- W2910608506 sameAs 2910608506 @default.
- W2910608506 citedByCount "1" @default.
- W2910608506 countsByYear W29106085062021 @default.
- W2910608506 crossrefType "posted-content" @default.
- W2910608506 hasAuthorship W2910608506A5045168589 @default.
- W2910608506 hasAuthorship W2910608506A5056545178 @default.
- W2910608506 hasAuthorship W2910608506A5057662792 @default.
- W2910608506 hasAuthorship W2910608506A5073334415 @default.
- W2910608506 hasBestOaLocation W29106085061 @default.
- W2910608506 hasConcept C104317684 @default.
- W2910608506 hasConcept C192838845 @default.
- W2910608506 hasConcept C30481170 @default.
- W2910608506 hasConcept C54355233 @default.
- W2910608506 hasConcept C70721500 @default.
- W2910608506 hasConcept C83640560 @default.
- W2910608506 hasConcept C86803240 @default.
- W2910608506 hasConcept C95444343 @default.
- W2910608506 hasConceptScore W2910608506C104317684 @default.
- W2910608506 hasConceptScore W2910608506C192838845 @default.
- W2910608506 hasConceptScore W2910608506C30481170 @default.
- W2910608506 hasConceptScore W2910608506C54355233 @default.
- W2910608506 hasConceptScore W2910608506C70721500 @default.
- W2910608506 hasConceptScore W2910608506C83640560 @default.
- W2910608506 hasConceptScore W2910608506C86803240 @default.
- W2910608506 hasConceptScore W2910608506C95444343 @default.
- W2910608506 hasLocation W29106085061 @default.
- W2910608506 hasLocation W29106085062 @default.
- W2910608506 hasLocation W29106085063 @default.
- W2910608506 hasOpenAccess W2910608506 @default.
- W2910608506 hasPrimaryLocation W29106085061 @default.
- W2910608506 hasRelatedWork W1828691184 @default.