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- W2910670728 endingPage "61" @default.
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- W2910670728 abstract "The epigenetic machinery deputed to control histone post-translational modifications is frequently dysregulated in cancer cells. With epigenetics being naturally reversible, it represents a good target for therapies directed to restore normal gene expression. Since the discovery of Bromodomain and Extra Terminal (BET) inhibitors, a great effort has been spent investigating the effects of chromatin readers’ inhibition, specifically the class of proteins assigned to bind acetylated and methylated residues. So far, focused studies have been produced on epigenetic regulation, dissecting a specific class of epigenetic-related proteins or investigating epigenetic therapy in a specific tumor type. In this review, recent steps toward drug discovery on the different classes of chromatin readers have been outlined, highlighting the pros and cons of current therapeutic approaches." @default.
- W2910670728 created "2019-01-25" @default.
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- W2910670728 date "2019-01-09" @default.
- W2910670728 modified "2023-10-15" @default.
- W2910670728 title "Reading Cancer: Chromatin Readers as Druggable Targets for Cancer Treatment" @default.
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- W2910670728 doi "https://doi.org/10.3390/cancers11010061" @default.
- W2910670728 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6356452" @default.
- W2910670728 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30634442" @default.
- W2910670728 hasPublicationYear "2019" @default.
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