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• W2910694408 abstract "Brexpiprazole for the maintenance treatment of adults with schizophrenia: an evidence-based review and place in therapy Kristen Ward,1 Leslie Citrome2 1Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA; 2Department of Psychiatry and Behavioral Science, New York Medical College, Valhalla, NY, USA Abstract: The purpose of this review is to describe the available data for brexpiprazole in the maintenance treatment of schizophrenia. This objective was completed by searching the databases PubMed, Embase, and ClinicalTrials.gov to identify relevant study results presented as papers or abstracts. In summary, brexpiprazole is a new agent in the D2 partial agonist class that has a unique receptor-binding profile, based in part on high affinity for serotonin 5HT1A and 5HT2A receptors, paired with lower intrinsic activity at dopamine D2 receptors. The average dose used in efficacy and safety studies for the maintenance treatment of schizophrenia ranged from 3.0 and 3.1 mg in the open-label safety studies to 3.6 mg in the double-blind randomized relapse-prevention study. Highlights from the 52-week double-blind placebo-controlled relapse-prevention trial evidenced rates of relapse in the brexpiprazole group of 13.5% vs 38.5% in the placebo group (number needed to treat 4, 95% CI 3–8; P" @default.
• W2910694408 created "2019-01-25" @default.
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• W2910694408 date "2019-01-01" @default.
• W2910694408 modified "2023-09-27" @default.
• W2910694408 title "Brexpiprazole for the maintenance treatment of adults with schizophrenia: an evidence-based review and place in therapy" @default.
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• W2910694408 doi "https://doi.org/10.2147/ndt.s169369" @default.
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