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- W2910704734 endingPage "12482" @default.
- W2910704734 startingPage "12471" @default.
- W2910704734 abstract "Abstract Toll‐like receptors (TLRs) have a pivotal role in the activation of innate immune response and inflammation. TLRs can be divided into two subgroups including extracellular TLRs that recognize microbial membrane components (TLR1, 2, 4, 5, 6, and 10), and intracellular TLRs that recognize microbial nucleic acids (TLR3, 7, 8, and 9). Curcumin is a dietary polyphenol from Curcuma longa L. that is reputed to have diverse biological and pharmacological effects. Extensive research has defined the molecular mechanisms through which curcumin mediates its therapeutic effects. One newly defined and important target of curcumin is the TLR, where it exerts an inhibitory effect. In the current study, we focus upon the TLR antagonistic effect of curcumin and curcumin's therapeutic effect as mediated via TLR inhibition. The available evidence indicates that curcumin inhibits the extracellular TLR 2 and 4 and intracellular TLR9 and thereby exerts a therapeutic effect in diseases such as cancer, inflammation, infection, autoimmune, and ischemic disease. Curcumin effectively modulates the TLR response and thereby exerts its potent therapeutic effects." @default.
- W2910704734 created "2019-01-25" @default.
- W2910704734 creator A5023255400 @default.
- W2910704734 creator A5036163332 @default.
- W2910704734 creator A5073210035 @default.
- W2910704734 date "2019-01-08" @default.
- W2910704734 modified "2023-10-17" @default.
- W2910704734 title "Impact of curcumin on toll‐like receptors" @default.
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