Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910735087> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2910735087 endingPage "107" @default.
- W2910735087 startingPage "103" @default.
- W2910735087 abstract "Objective The long-term follow-up of patients with epilepsy harboring autoantibodies against the glycine receptor (also glycine receptor antibodies or GlyR-Ab) is not well-known. Our aim was to investigate the 5-year prognosis and treatment response of patients with epilepsy who were seropositive for GlyR-Ab. Methods Clinical features; electroencephalogram (EEG), neuroradiological, and neuropathological findings; and treatment responses of patients with epilepsy with GlyR-Ab seropositivity were investigated. Results Thirteen (5.46%) of 238 patients with epilepsy were GlyR-Ab positive: focal epilepsy of unknown cause (FEoUC) was diagnosed in four (7.27%) out of 55 patients, mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) in five (4.5%) out of 111 patients, epileptic encephalopathy (EE) in two (4%) out of 50 patients, and status epilepticus (SE) in two (9.09%) out of 22 patients. None of the patients developed any other neurological symptoms or cancer during the 5-year follow-up. Seven of them had seizures that were resistant to antiepileptic drug (AED). Immunotherapy was used in two patients (with FEoUC and EE) improving seizure control. Three patients with MTLE-HS benefited from epilepsy surgery, and another patient with EE showed spontaneous remission. Conclusion Glycine receptor antibodies are detected in a wide spectrum of epileptic disorders with unclear pathogenic significance. Two GlyR-Ab seropositive patients with AED-resistant epilepsy treated with intravenous immunoglobulin (IVIg) showed clear benefit from immunotherapy. Future studies will be valuable in determining the role of screening patients with drug-resistant epilepsy for GlyR-Ab in order to identify patients who may benefit or respond to immunotherapy." @default.
- W2910735087 created "2019-01-25" @default.
- W2910735087 creator A5014052855 @default.
- W2910735087 creator A5033197410 @default.
- W2910735087 creator A5038765962 @default.
- W2910735087 creator A5046003879 @default.
- W2910735087 creator A5050515710 @default.
- W2910735087 creator A5064815769 @default.
- W2910735087 creator A5068765931 @default.
- W2910735087 creator A5074968930 @default.
- W2910735087 creator A5084959768 @default.
- W2910735087 creator A5090178651 @default.
- W2910735087 date "2019-03-01" @default.
- W2910735087 modified "2023-10-18" @default.
- W2910735087 title "Follow-up of patients with epilepsy harboring antiglycine receptor antibodies" @default.
- W2910735087 cites W1920696238 @default.
- W2910735087 cites W1970404308 @default.
- W2910735087 cites W2072597173 @default.
- W2910735087 cites W2103644035 @default.
- W2910735087 cites W2148608812 @default.
- W2910735087 cites W2225673509 @default.
- W2910735087 cites W2346940452 @default.
- W2910735087 cites W2520569358 @default.
- W2910735087 cites W2617258020 @default.
- W2910735087 cites W2618157472 @default.
- W2910735087 cites W2747735418 @default.
- W2910735087 cites W2809290707 @default.
- W2910735087 cites W2810869876 @default.
- W2910735087 doi "https://doi.org/10.1016/j.yebeh.2018.09.034" @default.
- W2910735087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30641251" @default.
- W2910735087 hasPublicationYear "2019" @default.
- W2910735087 type Work @default.
- W2910735087 sameAs 2910735087 @default.
- W2910735087 citedByCount "11" @default.
- W2910735087 countsByYear W29107350872019 @default.
- W2910735087 countsByYear W29107350872021 @default.
- W2910735087 countsByYear W29107350872022 @default.
- W2910735087 countsByYear W29107350872023 @default.
- W2910735087 crossrefType "journal-article" @default.
- W2910735087 hasAuthorship W2910735087A5014052855 @default.
- W2910735087 hasAuthorship W2910735087A5033197410 @default.
- W2910735087 hasAuthorship W2910735087A5038765962 @default.
- W2910735087 hasAuthorship W2910735087A5046003879 @default.
- W2910735087 hasAuthorship W2910735087A5050515710 @default.
- W2910735087 hasAuthorship W2910735087A5064815769 @default.
- W2910735087 hasAuthorship W2910735087A5068765931 @default.
- W2910735087 hasAuthorship W2910735087A5074968930 @default.
- W2910735087 hasAuthorship W2910735087A5084959768 @default.
- W2910735087 hasAuthorship W2910735087A5090178651 @default.
- W2910735087 hasConcept C118552586 @default.
- W2910735087 hasConcept C126322002 @default.
- W2910735087 hasConcept C185592680 @default.
- W2910735087 hasConcept C2777341932 @default.
- W2910735087 hasConcept C2777597344 @default.
- W2910735087 hasConcept C2777756961 @default.
- W2910735087 hasConcept C2778186239 @default.
- W2910735087 hasConcept C2778621155 @default.
- W2910735087 hasConcept C2781099131 @default.
- W2910735087 hasConcept C35599011 @default.
- W2910735087 hasConcept C515207424 @default.
- W2910735087 hasConcept C55493867 @default.
- W2910735087 hasConcept C71924100 @default.
- W2910735087 hasConcept C90924648 @default.
- W2910735087 hasConceptScore W2910735087C118552586 @default.
- W2910735087 hasConceptScore W2910735087C126322002 @default.
- W2910735087 hasConceptScore W2910735087C185592680 @default.
- W2910735087 hasConceptScore W2910735087C2777341932 @default.
- W2910735087 hasConceptScore W2910735087C2777597344 @default.
- W2910735087 hasConceptScore W2910735087C2777756961 @default.
- W2910735087 hasConceptScore W2910735087C2778186239 @default.
- W2910735087 hasConceptScore W2910735087C2778621155 @default.
- W2910735087 hasConceptScore W2910735087C2781099131 @default.
- W2910735087 hasConceptScore W2910735087C35599011 @default.
- W2910735087 hasConceptScore W2910735087C515207424 @default.
- W2910735087 hasConceptScore W2910735087C55493867 @default.
- W2910735087 hasConceptScore W2910735087C71924100 @default.
- W2910735087 hasConceptScore W2910735087C90924648 @default.
- W2910735087 hasFunder F4320321387 @default.
- W2910735087 hasLocation W29107350871 @default.
- W2910735087 hasLocation W29107350872 @default.
- W2910735087 hasOpenAccess W2910735087 @default.
- W2910735087 hasPrimaryLocation W29107350871 @default.
- W2910735087 hasRelatedWork W131944516 @default.
- W2910735087 hasRelatedWork W177658873 @default.
- W2910735087 hasRelatedWork W2024721689 @default.
- W2910735087 hasRelatedWork W2053130025 @default.
- W2910735087 hasRelatedWork W2084663585 @default.
- W2910735087 hasRelatedWork W2754579297 @default.
- W2910735087 hasRelatedWork W2925411560 @default.
- W2910735087 hasRelatedWork W2955708951 @default.
- W2910735087 hasRelatedWork W3093130825 @default.
- W2910735087 hasRelatedWork W3135725291 @default.
- W2910735087 hasVolume "92" @default.
- W2910735087 isParatext "false" @default.
- W2910735087 isRetracted "false" @default.
- W2910735087 magId "2910735087" @default.
- W2910735087 workType "article" @default.