Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910780591> ?p ?o ?g. }
- W2910780591 abstract "Single-molecule cytoplasmic dynein function is well understood, but there are major gaps in mechanistic understanding of cellular dynein regulation. We reported a mode of dynein regulation, force adaptation, where lipid droplets adapt to opposition to motion by increasing the duration and magnitude of force production, and found LIS1 and NudEL to be essential. Adaptation reflects increasing NudEL-LIS1 utilization; here, we hypothesize that such increasing utilization reflects CDK5-mediated NudEL phosphorylation, which increases the dynein-NudEL interaction, and makes force adaptation possible. We report that CDK5, 14-3-3ε, and CDK5 cofactor KIAA0528 together promote NudEL phosphorylation and are essential for force adaptation. By studying the process in COS-1 cells lacking Tau, we avoid confounding neuronal effects of CDK5 on microtubules. Finally, we extend this in vivo regulatory pathway to lysosomes and mitochondria. Ultimately, we show that dynein force adaptation can control the severity of lysosomal tug-of-wars among other intracellular transport functions involving high force." @default.
- W2910780591 created "2019-01-25" @default.
- W2910780591 creator A5002864551 @default.
- W2910780591 creator A5020779732 @default.
- W2910780591 creator A5041595647 @default.
- W2910780591 creator A5050060171 @default.
- W2910780591 creator A5052340681 @default.
- W2910780591 creator A5056203665 @default.
- W2910780591 creator A5056380231 @default.
- W2910780591 creator A5056985811 @default.
- W2910780591 creator A5072906837 @default.
- W2910780591 creator A5078572492 @default.
- W2910780591 date "2019-01-16" @default.
- W2910780591 modified "2023-10-16" @default.
- W2910780591 title "Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528" @default.
- W2910780591 cites W1579194600 @default.
- W2910780591 cites W1773591497 @default.
- W2910780591 cites W1914313496 @default.
- W2910780591 cites W1955309278 @default.
- W2910780591 cites W1963489221 @default.
- W2910780591 cites W1964841325 @default.
- W2910780591 cites W1964999292 @default.
- W2910780591 cites W1972398314 @default.
- W2910780591 cites W1974454876 @default.
- W2910780591 cites W197448336 @default.
- W2910780591 cites W1985514602 @default.
- W2910780591 cites W1987012898 @default.
- W2910780591 cites W1989245013 @default.
- W2910780591 cites W2003825836 @default.
- W2910780591 cites W2003948083 @default.
- W2910780591 cites W2010366657 @default.
- W2910780591 cites W2022410893 @default.
- W2910780591 cites W2030434942 @default.
- W2910780591 cites W2033859483 @default.
- W2910780591 cites W2034725792 @default.
- W2910780591 cites W2035027593 @default.
- W2910780591 cites W2036364323 @default.
- W2910780591 cites W2036623899 @default.
- W2910780591 cites W2037835429 @default.
- W2910780591 cites W2038847041 @default.
- W2910780591 cites W2039252375 @default.
- W2910780591 cites W2050592587 @default.
- W2910780591 cites W2053830961 @default.
- W2910780591 cites W2055494790 @default.
- W2910780591 cites W2069689165 @default.
- W2910780591 cites W2077642972 @default.
- W2910780591 cites W2086102771 @default.
- W2910780591 cites W2088163646 @default.
- W2910780591 cites W2091857357 @default.
- W2910780591 cites W2094228287 @default.
- W2910780591 cites W2095317177 @default.
- W2910780591 cites W2098889694 @default.
- W2910780591 cites W2104988846 @default.
- W2910780591 cites W2108653140 @default.
- W2910780591 cites W2110488004 @default.
- W2910780591 cites W2117007172 @default.
- W2910780591 cites W2122825604 @default.
- W2910780591 cites W2123607569 @default.
- W2910780591 cites W2129146864 @default.
- W2910780591 cites W2129677617 @default.
- W2910780591 cites W2134505334 @default.
- W2910780591 cites W2138149271 @default.
- W2910780591 cites W2142616907 @default.
- W2910780591 cites W2142694622 @default.
- W2910780591 cites W2142921367 @default.
- W2910780591 cites W2158190317 @default.
- W2910780591 cites W2193673085 @default.
- W2910780591 cites W2299614729 @default.
- W2910780591 cites W2479788400 @default.
- W2910780591 cites W2488716085 @default.
- W2910780591 cites W2529684147 @default.
- W2910780591 cites W2559180804 @default.
- W2910780591 cites W2621147699 @default.
- W2910780591 cites W2751859780 @default.
- W2910780591 cites W2758801732 @default.
- W2910780591 cites W2773503067 @default.
- W2910780591 cites W842010963 @default.
- W2910780591 doi "https://doi.org/10.1038/s41467-018-08110-z" @default.
- W2910780591 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6335402" @default.
- W2910780591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30651536" @default.
- W2910780591 hasPublicationYear "2019" @default.
- W2910780591 type Work @default.
- W2910780591 sameAs 2910780591 @default.
- W2910780591 citedByCount "17" @default.
- W2910780591 countsByYear W29107805912019 @default.
- W2910780591 countsByYear W29107805912020 @default.
- W2910780591 countsByYear W29107805912021 @default.
- W2910780591 countsByYear W29107805912022 @default.
- W2910780591 countsByYear W29107805912023 @default.
- W2910780591 crossrefType "journal-article" @default.
- W2910780591 hasAuthorship W2910780591A5002864551 @default.
- W2910780591 hasAuthorship W2910780591A5020779732 @default.
- W2910780591 hasAuthorship W2910780591A5041595647 @default.
- W2910780591 hasAuthorship W2910780591A5050060171 @default.
- W2910780591 hasAuthorship W2910780591A5052340681 @default.
- W2910780591 hasAuthorship W2910780591A5056203665 @default.
- W2910780591 hasAuthorship W2910780591A5056380231 @default.
- W2910780591 hasAuthorship W2910780591A5056985811 @default.
- W2910780591 hasAuthorship W2910780591A5072906837 @default.
- W2910780591 hasAuthorship W2910780591A5078572492 @default.