FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910792017> ?p ?o ?g. }

• W2910792017 abstract "The nuclear receptor COUP TFI (also known as Nr2f1) plays major roles in specifying distinct neuronal subtypes during patterning of the neocortical motor and somatosensory cortex, as well as in regulating the longitudinal growth of the hippocampus during development. In humans, mutations in the NR2F1 gene lead to a global developmental delay and intellectual disabilities. While more than 30% of patients show behavioral features of autism spectrum disorder, 16% of haploinsufficient children show signs of hyperactivity and impulsivity. Loss of COUP‐TFI in the cortical mouse primordium results in altered area organization and serotonin distribution, abnormal coordination of voluntary movements and learning and memory deficits. Here, we asked whether absence of COUP‐TFI affects locomotor activity, anxiety, as well as depression. Mice mutant for COUP‐TFI have normal motor coordination, but significant traits of hyperactivity, which does not seem to respond to N‐Methyl‐D‐aspartate (NMDA) antagonists. However, no changes in anxiety, despite increased locomotor performances, were observed in the open field task. On the contrary, elevated plus maze and dark‐light test explorations indicate a decreased anxiety‐like behavior in COUP‐TFI mutant mice. Finally, significantly reduced immobility in the forced swim test and no changes in anhedonia in the sucrose preference task suggest no particular depressive behaviors in mutant mice. Taken together, our study shows that loss of COUP‐TFI leads to increased locomotor activity but less anxiety and contributes in further deciphering the pathophysiology of patients haploinsufficient for NR2F1." @default.
• W2910792017 created "2019-01-25" @default.
• W2910792017 creator A5048964608 @default.
• W2910792017 creator A5055106930 @default.
• W2910792017 creator A5062053465 @default.
• W2910792017 creator A5074101024 @default.
• W2910792017 creator A5089207995 @default.
• W2910792017 date "2019-02-10" @default.
• W2910792017 modified "2023-10-17" @default.
• W2910792017 title "Hyperactive and anxiolytic‐like behaviors result from loss of COUP‐TFI/Nr2f1 in the mouse cortex" @default.
• W2910792017 cites W1829962002 @default.
• W2910792017 cites W1964160578 @default.
• W2910792017 cites W1966037459 @default.
• W2910792017 cites W1970720793 @default.
• W2910792017 cites W1982309599 @default.
• W2910792017 cites W1999040534 @default.
• W2910792017 cites W2011969322 @default.
• W2910792017 cites W2012266823 @default.
• W2910792017 cites W2013687487 @default.
• W2910792017 cites W2020778578 @default.
• W2910792017 cites W2030576824 @default.
• W2910792017 cites W2053714798 @default.
• W2910792017 cites W2066780833 @default.
• W2910792017 cites W2067059933 @default.
• W2910792017 cites W2067663595 @default.
• W2910792017 cites W2076854586 @default.
• W2910792017 cites W2089299823 @default.
• W2910792017 cites W2109630386 @default.
• W2910792017 cites W2112074923 @default.
• W2910792017 cites W2114353262 @default.
• W2910792017 cites W2118069096 @default.
• W2910792017 cites W2137842916 @default.
• W2910792017 cites W2147310208 @default.
• W2910792017 cites W2162423225 @default.
• W2910792017 cites W2170967913 @default.
• W2910792017 cites W2229859804 @default.
• W2910792017 cites W2299299128 @default.
• W2910792017 cites W2313749244 @default.
• W2910792017 cites W2532273158 @default.
• W2910792017 cites W2581271233 @default.
• W2910792017 cites W2729462249 @default.
• W2910792017 cites W2757281294 @default.
• W2910792017 cites W2781922735 @default.
• W2910792017 cites W2789287511 @default.
• W2910792017 cites W2863657004 @default.
• W2910792017 cites W2888290218 @default.
• W2910792017 doi "https://doi.org/10.1111/gbb.12556" @default.
• W2910792017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30653836" @default.
• W2910792017 hasPublicationYear "2019" @default.
• W2910792017 type Work @default.
• W2910792017 sameAs 2910792017 @default.
• W2910792017 citedByCount "9" @default.
• W2910792017 countsByYear W29107920172019 @default.
• W2910792017 countsByYear W29107920172020 @default.
• W2910792017 countsByYear W29107920172021 @default.
• W2910792017 countsByYear W29107920172022 @default.
• W2910792017 countsByYear W29107920172023 @default.
• W2910792017 crossrefType "journal-article" @default.
• W2910792017 hasAuthorship W2910792017A5048964608 @default.
• W2910792017 hasAuthorship W2910792017A5055106930 @default.
• W2910792017 hasAuthorship W2910792017A5062053465 @default.
• W2910792017 hasAuthorship W2910792017A5074101024 @default.
• W2910792017 hasAuthorship W2910792017A5089207995 @default.
• W2910792017 hasBestOaLocation W29107920171 @default.
• W2910792017 hasConcept C104317684 @default.
• W2910792017 hasConcept C113062710 @default.
• W2910792017 hasConcept C118552586 @default.
• W2910792017 hasConcept C126322002 @default.
• W2910792017 hasConcept C127716648 @default.
• W2910792017 hasConcept C136569192 @default.
• W2910792017 hasConcept C15744967 @default.
• W2910792017 hasConcept C169760540 @default.
• W2910792017 hasConcept C170493617 @default.
• W2910792017 hasConcept C2777765862 @default.
• W2910792017 hasConcept C2778941446 @default.
• W2910792017 hasConcept C2779085643 @default.
• W2910792017 hasConcept C2779177272 @default.
• W2910792017 hasConcept C2781161787 @default.
• W2910792017 hasConcept C513476851 @default.
• W2910792017 hasConcept C55493867 @default.
• W2910792017 hasConcept C558461103 @default.
• W2910792017 hasConcept C67018056 @default.
• W2910792017 hasConcept C68838962 @default.
• W2910792017 hasConcept C71924100 @default.
• W2910792017 hasConcept C86803240 @default.
• W2910792017 hasConceptScore W2910792017C104317684 @default.
• W2910792017 hasConceptScore W2910792017C113062710 @default.
• W2910792017 hasConceptScore W2910792017C118552586 @default.
• W2910792017 hasConceptScore W2910792017C126322002 @default.
• W2910792017 hasConceptScore W2910792017C127716648 @default.
• W2910792017 hasConceptScore W2910792017C136569192 @default.
• W2910792017 hasConceptScore W2910792017C15744967 @default.
• W2910792017 hasConceptScore W2910792017C169760540 @default.
• W2910792017 hasConceptScore W2910792017C170493617 @default.
• W2910792017 hasConceptScore W2910792017C2777765862 @default.
• W2910792017 hasConceptScore W2910792017C2778941446 @default.
• W2910792017 hasConceptScore W2910792017C2779085643 @default.
• W2910792017 hasConceptScore W2910792017C2779177272 @default.
• W2910792017 hasConceptScore W2910792017C2781161787 @default.
• W2910792017 hasConceptScore W2910792017C513476851 @default.

• next