FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2910793003> ?p ?o ?g. }

• W2910793003 abstract "Background The antinuclear antibody (ANA) test is often used as a screening test to aid in the diagnosis of systemic lupus erythematous (SLE and other systemic autoimmune rheumatic diseases (SARD). However, recently it was reported that a certain autoantibody referred to as anti-dense fine speckled 70 (DFS70) are much more common (up to 25%) of non-SARD and healthy individuals but rare Objectives The primary objective of our study was to determine the frequency of ant-DFS70 in menopausal women who were referred for evaluation of undifferentiated arthritis (UA). Methods 282 women including 105 with UA and an age range of 27~91 years (mean=60.3) were enrolled. Menopausal women were divided into pre-, peri-, and post-menopausal stages according to menstrual regularity. (E2), Follicle stimulating hormone (FSH), rheumatoid factor (RF), ANA (by indirect immunofluorescence (IIF) (MBL) anti-cyclic citrullinated peptide antibody (ACPA: MBL ELISA) and C-reactive protein (CRP) were included in the serology workup. Postmenopausal arthralgia was designated PoMA and perimenopausal arthralgia PeMA. Results In PoMA women who received HRT for two months estradiol levels increased, FSH levels decreased and the joint pain visual analogue scale was reduced by 70%, as compared to baseline. Similarly in PeMA women, administration of 600 mg tocopherol N daily had the same efficacy as that observed in PoMA. The overall frequency of anti-DFS70 of 26.7% (28/105) in PoMA and PeMA women was significantly higher than that in UA females who were diagnosed with rheumatoid arthritis (RA) (7/65:10.8%) or primary Sjogren’s syndrome (SjS) (3/31: 9.7%) (p 1/320) were observed in the females that were diagnosed as systemic lupus erythematosus (SLE) (30%) or primary SjS (48.4%), the majority of whom had lower titers of anti-DFS70, although several sera contained both high titer ANA and anti-DFS70 (see figure). Conclusions Anti-DFS70 was found in higher frequency in PeMA and PoMA women than in women who developed a defined systemic autoimmune rheumatic disease such as SLE, SjS or RA. This is the first study to suggest that the presence of this autoantibody may reflect oestrogen fluctuations or deficiency. A negative association between ANA titer and anti-DFS70 levels by ELISA remains to be confirmed in larger studies. References [1] M. Mahler, P. L. Meroni, L. E. Andrade, M. Khamashta, N. Bizzaro, C. A. Casiano, and M. J. Fritzler. Towards a better understanding of the clinical association of anti-DFS70 autoantibodies. Autoimmun. Rev. 15:198–201, 2016. [2] K. Conrad, N. Rober, L. E. Andrade, and M. Mahler. The Clinical Relevance of Anti-DFS70 Autoantibodies. Clin. Rev. Allergy Immunol. 52:202–216, 2016. Disclosure of Interest K. Miyachi Shareholder of: none, Grant/research support from: none, Consultant for: none, A. Ihar: None declared, B. Sasse: None declared, M. Y. Choi: None declared, M. J. Fritzler: None declared" @default.
• W2910793003 created "2019-01-25" @default.
• W2910793003 creator A5011458972 @default.
• W2910793003 creator A5035984700 @default.
• W2910793003 creator A5050807193 @default.
• W2910793003 creator A5081178643 @default.
• W2910793003 creator A5084739987 @default.
• W2910793003 date "2018-06-01" @default.
• W2910793003 modified "2023-09-27" @default.
• W2910793003 title "AB1325 The frequency of anti-dfs70 autoantibodies in japanese women with peri- and post-menopausal arthralgia" @default.
• W2910793003 doi "https://doi.org/10.1136/annrheumdis-2018-eular.2013" @default.
• W2910793003 hasPublicationYear "2018" @default.
• W2910793003 type Work @default.
• W2910793003 sameAs 2910793003 @default.
• W2910793003 citedByCount "0" @default.
• W2910793003 crossrefType "proceedings-article" @default.
• W2910793003 hasAuthorship W2910793003A5011458972 @default.
• W2910793003 hasAuthorship W2910793003A5035984700 @default.
• W2910793003 hasAuthorship W2910793003A5050807193 @default.
• W2910793003 hasAuthorship W2910793003A5081178643 @default.
• W2910793003 hasAuthorship W2910793003A5084739987 @default.
• W2910793003 hasBestOaLocation W29107930031 @default.
• W2910793003 hasConcept C126322002 @default.
• W2910793003 hasConcept C149443304 @default.
• W2910793003 hasConcept C159654299 @default.
• W2910793003 hasConcept C163764329 @default.
• W2910793003 hasConcept C203014093 @default.
• W2910793003 hasConcept C2776232647 @default.
• W2910793003 hasConcept C2777077863 @default.
• W2910793003 hasConcept C2777575956 @default.
• W2910793003 hasConcept C71924100 @default.
• W2910793003 hasConcept C90924648 @default.
• W2910793003 hasConceptScore W2910793003C126322002 @default.
• W2910793003 hasConceptScore W2910793003C149443304 @default.
• W2910793003 hasConceptScore W2910793003C159654299 @default.
• W2910793003 hasConceptScore W2910793003C163764329 @default.
• W2910793003 hasConceptScore W2910793003C203014093 @default.
• W2910793003 hasConceptScore W2910793003C2776232647 @default.
• W2910793003 hasConceptScore W2910793003C2777077863 @default.
• W2910793003 hasConceptScore W2910793003C2777575956 @default.
• W2910793003 hasConceptScore W2910793003C71924100 @default.
• W2910793003 hasConceptScore W2910793003C90924648 @default.
• W2910793003 hasLocation W29107930031 @default.
• W2910793003 hasOpenAccess W2910793003 @default.
• W2910793003 hasPrimaryLocation W29107930031 @default.
• W2910793003 hasRelatedWork W1972107557 @default.
• W2910793003 hasRelatedWork W1976122878 @default.
• W2910793003 hasRelatedWork W1996257576 @default.
• W2910793003 hasRelatedWork W2015127867 @default.
• W2910793003 hasRelatedWork W2323592636 @default.
• W2910793003 hasRelatedWork W2331432053 @default.
• W2910793003 hasRelatedWork W2417978693 @default.
• W2910793003 hasRelatedWork W2520316569 @default.
• W2910793003 hasRelatedWork W2591058303 @default.
• W2910793003 hasRelatedWork W2735656135 @default.
• W2910793003 hasRelatedWork W2755586393 @default.
• W2910793003 hasRelatedWork W2804044732 @default.
• W2910793003 hasRelatedWork W2909330607 @default.
• W2910793003 hasRelatedWork W2913847516 @default.
• W2910793003 hasRelatedWork W2945175597 @default.
• W2910793003 hasRelatedWork W2950134454 @default.
• W2910793003 hasRelatedWork W2952027148 @default.
• W2910793003 hasRelatedWork W3044076008 @default.
• W2910793003 hasRelatedWork W3104373170 @default.
• W2910793003 hasRelatedWork W3158211117 @default.
• W2910793003 isParatext "false" @default.
• W2910793003 isRetracted "false" @default.
• W2910793003 magId "2910793003" @default.
• W2910793003 workType "article" @default.